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The inaccuracy of neural network models on inputs that do not stem from the training data distribution is both problematic and at times unrecognized. Model uncertainty estimation can address this issue, where uncertainty estimates are often…

Machine Learning · Computer Science 2020-02-14 Siddhartha Jain , Ge Liu , Jonas Mueller , David Gifford

Multimodal tabular-image fusion is an emerging task that has received increasing attention in various domains. However, existing methods may be hindered by gradient conflicts between modalities, misleading the optimization of the unimodal…

Computer Vision and Pattern Recognition · Computer Science 2026-04-03 Longfei Huang , Yang Yang

Alzheimer's disease (AD) is a progressive neurodegenerative disease with high inter-patient variance in rate of cognitive decline. AD progression prediction aims to forecast patient cognitive decline and benefits from incorporating multiple…

Machine Learning · Computer Science 2025-09-17 Benjamin Burns , Yuan Xue , Douglas W. Scharre , Xia Ning

Multimodal semantic understanding often has to deal with uncertainty, which means the obtained messages tend to refer to multiple targets. Such uncertainty is problematic for our interpretation, including inter- and intra-modal uncertainty.…

Computer Vision and Pattern Recognition · Computer Science 2023-07-21 Yatai Ji , Junjie Wang , Yuan Gong , Lin Zhang , Yanru Zhu , Hongfa Wang , Jiaxing Zhang , Tetsuya Sakai , Yujiu Yang

Recent technological advances in healthcare have led to unprecedented growth in patient data quantity and diversity. While artificial intelligence (AI) models have shown promising results in analyzing individual data modalities, there is…

Artificial Intelligence · Computer Science 2024-11-07 Daan Schouten , Giulia Nicoletti , Bas Dille , Catherine Chia , Pierpaolo Vendittelli , Megan Schuurmans , Geert Litjens , Nadieh Khalili

Medical decision systems increasingly rely on data from multiple sources to ensure reliable and unbiased diagnosis. However, existing multimodal learning models fail to achieve this goal because they often ignore two critical challenges.…

Machine Learning · Computer Science 2025-10-10 Md Zubair , Hao Zheng , Nussdorf Jonathan , Grayson W. Armstrong , Lucy Q. Shen , Gabriela Wilson , Yu Tian , Xingquan Zhu , Min Shi

The Intensive Care Unit (ICU) is a hospital department where machine learning has the potential to provide valuable assistance in clinical decision making. Classical machine learning models usually only provide point-estimates and no…

Machine Learning · Computer Science 2024-07-26 David Ruhe , Giovanni Cinà , Michele Tonutti , Daan de Bruin , Paul Elbers

The acquisition of different data modalities can enhance our knowledge and understanding of various diseases, paving the way for a more personalized healthcare. Thus, medicine is progressively moving towards the generation of massive…

Image and Video Processing · Electrical Eng. & Systems 2024-05-06 Tiago Mota , M. Rita Verdelho , Alceu Bissoto , Carlos Santiago , Catarina Barata

In medical vision, different imaging modalities provide complementary information. However, in practice, not all modalities may be available during inference or even training. Previous approaches, e.g., knowledge distillation or image…

Computer Vision and Pattern Recognition · Computer Science 2023-08-23 Aishik Konwer , Xiaoling Hu , Joseph Bae , Xuan Xu , Chao Chen , Prateek Prasanna

Multimodal neuroimaging provides complementary insights for Alzheimer's disease diagnosis, yet clinical datasets frequently suffer from missing modalities. We propose ACADiff, a framework that synthesizes missing brain imaging modalities…

Computer Vision and Pattern Recognition · Computer Science 2026-03-11 Rong Zhou , Houliang Zhou , Yao Su , Brian Y. Chen , Yu Zhang , Lifang He , Alzheimer's Disease Neuroimaging Initiative

Accurate segmentation of brain tumors from magnetic resonance imaging (MRI) is clinically relevant in diagnoses, prognoses and surgery treatment, which requires multiple modalities to provide complementary morphological and physiopathologic…

Image and Video Processing · Electrical Eng. & Systems 2021-06-30 Yixin Wang , Yang Zhang , Yang Liu , Zihao Lin , Jiang Tian , Cheng Zhong , Zhongchao Shi , Jianping Fan , Zhiqiang He

The integration of deep learning in medical imaging has shown great promise for enhancing diagnostic, therapeutic, and research outcomes. However, applying universal models across multiple modalities remains challenging due to the inherent…

Image and Video Processing · Electrical Eng. & Systems 2024-12-30 Yixin Chen , Lin Gao , Yajuan Gao , Rui Wang , Jingge Lian , Xiangxi Meng , Yanhua Duan , Leiying Chai , Hongbin Han , Zhaoping Cheng , Zhaoheng Xie

Deep learning models frequently encounter feature uncertainty in diverse learning scenarios, significantly impacting their performance and reliability. This challenge is particularly complex in multi-modal scenarios, where models must…

Machine Learning · Computer Science 2025-06-05 Jiahao Qin , Bei Peng , Feng Liu , Guangliang Cheng , Lu Zong

Building reliable speech systems often requires combining multiple modalities, like audio and visual cues. While such multimodal solutions frequently lead to improvements in performance and may even be critical in certain cases, they come…

Sound · Computer Science 2025-01-31 Joanna Hong , Sanjeel Parekh , Honglie Chen , Jacob Donley , Ke Tan , Buye Xu , Anurag Kumar

In medicine, both ethical and monetary costs of incorrect predictions can be significant, and the complexity of the problems often necessitates increasingly complex models. Recent work has shown that changing just the random seed is enough…

Emergence of artificial intelligence techniques in biomedical applications urges the researchers to pay more attention on the uncertainty quantification (UQ) in machine-assisted medical decision making. For classification tasks, prior…

Machine Learning · Computer Science 2019-09-17 Xiaoyang Huang , Jiancheng Yang , Linguo Li , Haoran Deng , Bingbing Ni , Yi Xu

This study addresses the critical issue of reliability for AI-assisted medical diagnosis. We focus on the selection prediction approach that allows the diagnosis system to abstain from providing the decision if it is not confident in the…

Multimodal learning has mainly focused on learning large models on, and fusing feature representations from, different modalities for better performances on downstream tasks. In this work, we take a detour from this trend and study the…

Computer Vision and Pattern Recognition · Computer Science 2023-05-08 Yifeng Shi , Marc Niethammer

Multi-modal learning focuses on training models by equally combining multiple input data modalities during the prediction process. However, this equal combination can be detrimental to the prediction accuracy because different modalities…

Computer Vision and Pattern Recognition · Computer Science 2022-07-25 Hu Wang , Jianpeng Zhang , Yuanhong Chen , Congbo Ma , Jodie Avery , Louise Hull , Gustavo Carneiro

Accurate survival prediction from multimodal medical data is essential for precision oncology, yet clinical deployment faces a persistent challenge: modalities are frequently incomplete due to cost constraints, technical limitations, or…

Computer Vision and Pattern Recognition · Computer Science 2026-03-30 Kyungwon Kim , Dosik Hwang