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Recent advances in vision language models (VLMs) have enabled broad progress in the general medical field. However, pathology still remains a more challenging subdomain, with current pathology specific VLMs exhibiting limitations in both…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Wenchuan Zhang , Penghao Zhang , Jingru Guo , Tao Cheng , Jie Chen , Shuwan Zhang , Zhang Zhang , Yuhao Yi , Hong Bu

The diagnosis of pathological images is often limited by expert availability and regional disparities, highlighting the importance of automated diagnosis using Vision-Language Models (VLMs). Traditional multimodal models typically emphasize…

Computer Vision and Pattern Recognition · Computer Science 2025-04-21 Jianyu Wu , Hao Yang , Xinhua Zeng , Guibing He , Zhiyu Chen , Zihui Li , Xiaochuan Zhang , Yangyang Ma , Run Fang , Yang Liu

Multimodal large language models (MLLMs) have emerged as powerful tools for computational pathology, offering unprecedented opportunities to integrate pathological images with language context for comprehensive diagnostic analysis. These…

Image and Video Processing · Electrical Eng. & Systems 2025-08-20 Zhe Xu , Ziyi Liu , Junlin Hou , Jiabo Ma , Cheng Jin , Yihui Wang , Zhixuan Chen , Zhengyu Zhang , Fuxiang Huang , Zhengrui Guo , Fengtao Zhou , Yingxue Xu , Xi Wang , Ronald Cheong Kin Chan , Li Liang , Hao Chen

Computational pathology demands both visual pattern recognition and dynamic integration of structured domain knowledge, including taxonomy, grading criteria, and clinical evidence. In practice, diagnostic reasoning requires linking…

Artificial Intelligence · Computer Science 2026-05-26 Jinyue Li , Yuci Liang , Qiankun Li , Xinheng Lyu , Jiayu Qian , Huabao Chen , Kun Wang , Zhigang Zeng , Anil Anthony Bharath , Yang Liu

Multimodal large models have shown great potential in automating pathology image analysis. However, current multimodal models for gastrointestinal pathology are constrained by both data quality and reasoning transparency: pervasive noise…

Image and Video Processing · Electrical Eng. & Systems 2025-07-25 Minxi Ouyang , Lianghui Zhu , Yaqing Bao , Qiang Huang , Jingli Ouyang , Tian Guan , Xitong Ling , Jiawen Li , Song Duan , Wenbin Dai , Li Zheng , Xuemei Zhang , Yonghong He

Reasoning is a critical frontier for advancing medical image analysis, where transparency and trustworthiness play a central role in both clinician trust and regulatory approval. Although Medical Visual Language Models (VLMs) show promise…

Computer Vision and Pattern Recognition · Computer Science 2025-03-20 Jiazhen Pan , Che Liu , Junde Wu , Fenglin Liu , Jiayuan Zhu , Hongwei Bran Li , Chen Chen , Cheng Ouyang , Daniel Rueckert

Analyzing whole-slide images (WSIs) requires an iterative, evidence-driven reasoning process that parallels how pathologists dynamically zoom, refocus, and self-correct while collecting the evidence. However, existing computational…

Computer Vision and Pattern Recognition · Computer Science 2025-11-24 Jingyun Chen , Linghan Cai , Zhikang Wang , Yi Huang , Songhan Jiang , Shenjin Huang , Hongpeng Wang , Yongbing Zhang

In recent years, significant progress has been made in the field of surgical scene understanding, particularly in the task of Visual Question Localized-Answering in robotic surgery (Surgical-VQLA). However, existing Surgical-VQLA models…

Computer Vision and Pattern Recognition · Computer Science 2025-06-25 Pengfei Hao , Shuaibo Li , Hongqiu Wang , Zhizhuo Kou , Junhang Zhang , Guang Yang , Lei Zhu

Surgical scene understanding demands not only accurate predictions but also interpretable reasoning that surgeons can verify against clinical expertise. However, existing surgical vision-language models generate predictions without…

Despite their success, current training pipelines for reasoning VLMs focus on a limited range of tasks, such as mathematical and logical reasoning. As a result, these models face difficulties in generalizing their reasoning capabilities to…

Computer Vision and Pattern Recognition · Computer Science 2025-08-19 Yuheng Zha , Kun Zhou , Yujia Wu , Yushu Wang , Jie Feng , Zhi Xu , Shibo Hao , Zhengzhong Liu , Eric P. Xing , Zhiting Hu

General-purpose large Vision-Language Models (VLMs) demonstrate strong capabilities in generating detailed descriptions for natural images. However, their performance in the medical domain remains suboptimal, even for relatively…

Computer Vision and Pattern Recognition · Computer Science 2025-10-23 Yifan Li , Fenghe Tang , Yingtai Li , Shaohua Kevin Zhou

Deep learning based automated pathological diagnosis has markedly improved diagnostic efficiency and reduced variability between observers, yet its clinical adoption remains limited by opaque model decisions and a lack of traceable…

The emergence of vision-language models (VLMs) has opened new possibilities for clinical reasoning and has shown promising performance in dermatological diagnosis. However, their trustworthiness and clinical utility are often limited by…

Computer Vision and Pattern Recognition · Computer Science 2025-11-20 Zehao Liu , Wejieying Ren , Jipeng Zhang , Tianxiang Zhao , Jingxi Zhu , Xiaoting Li , Vasant G. Honavar

Pathology is experiencing rapid digital transformation driven by whole-slide imaging and artificial intelligence (AI). While deep learning-based computational pathology has achieved notable success, traditional models primarily focus on…

Pathological diagnosis is vital for determining disease characteristics, guiding treatment, and assessing prognosis, relying heavily on detailed, multi-scale analysis of high-resolution whole slide images (WSI). However, existing large…

Computer Vision and Pattern Recognition · Computer Science 2025-05-19 Shengxuming Zhang , Weihan Li , Tianhong Gao , Jiacong Hu , Haoming Luo , Xiuming Zhang , Jing Zhang , Mingli Song , Zunlei Feng

Large vision-language models (VLMs) have made significant strides in 2D visual understanding tasks, sparking interest in extending these capabilities to 3D scene understanding. However, current 3D VLMs often struggle with robust reasoning…

Computer Vision and Pattern Recognition · Computer Science 2025-08-01 Ting Huang , Zeyu Zhang , Hao Tang

In Computational Pathology (CPath), the introduction of Vision-Language Models (VLMs) has opened new avenues for research, focusing primarily on aligning image-text pairs at a single magnification level. However, this approach might not be…

Computer Vision and Pattern Recognition · Computer Science 2025-04-29 Shahad Albastaki , Anabia Sohail , Iyyakutti Iyappan Ganapathi , Basit Alawode , Asim Khan , Sajid Javed , Naoufel Werghi , Mohammed Bennamoun , Arif Mahmood

Deciphering tumor microenvironment from Whole Slide Images (WSIs) is intriguing as it is key to cancer diagnosis, prognosis and treatment response. While these gigapixel images on one hand offer a comprehensive portrait of cancer, on the…

Computer Vision and Pattern Recognition · Computer Science 2025-12-01 Kunpeng Zhang , Hanwen Xu , Sheng Wang

Vision-language models (VLMs) have achieved remarkable success across diverse tasks. However, concerns about their trustworthiness persist, particularly regarding tendencies to lean more on textual cues than visual evidence and the risk of…

Computer Vision and Pattern Recognition · Computer Science 2026-04-07 Shizhan Gong , Minda Hu , Qiyuan Zhang , Chen Ma , Qi Dou

Recent advances in vision-language models (VLMs) have shown remarkable potential in bridging visual and textual modalities. In computational pathology, domain-specific VLMs, which are pre-trained on extensive histopathology image-text…

Computer Vision and Pattern Recognition · Computer Science 2025-03-03 Anh Tien Nguyen , Keunho Byeon , Kyungeun Kim , Jin Tae Kwak
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