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Dynamic Photoacoustic Computed Tomography (PACT) is an important imaging technique for monitoring physiological processes, capable of providing high-contrast images of optical absorption at much greater depths than traditional optical…

Image and Video Processing · Electrical Eng. & Systems 2025-06-05 Youshen Xiao , Yiling Shi , Ruixi Sun , Hongjiang Wei , Fei Gao , Yuyao Zhang

Photoacoustic tomography (PAT) is a rapidly-evolving medical imaging modality that combines optical absorption contrast with ultrasound imaging depth. One challenge in PAT is image reconstruction with inadequate acoustic signals due to…

Photoacoustic tomography (PAT) is a medical imaging modality that can provide high-resolution tissue images based on the optical absorption. Classical reconstruction methods for quantifying the absorption coefficients rely on sufficient…

Image and Video Processing · Electrical Eng. & Systems 2026-04-24 Anssi Manninen , Janek Gröhl , Felix Lucka , Andreas Hauptmann

In photoacoustic computed tomography (PACT) with short-pulsed laser excitation, wideband acoustic signals are generated in biological tissues with frequencies related to the effective shapes and sizes of the optically absorbing targets.…

The literature on reconstruction formulas for photoacoustic tomography (PAT) is vast. The various reconstruction formulas differ by used measurement devices and geometry on which the data are sampled. In standard photoacoustic imaging…

Analysis of PDEs · Mathematics 2015-05-30 Peter Elbau , Otmar Scherzer , Rainer Schulze

Two-photon photoacoustic tomography (TP-PAT) is a non-invasive optical molecular imaging modality that aims at inferring two-photon absorption property of heterogeneous media from photoacoustic measurements. In this work, we analyze an…

Analysis of PDEs · Mathematics 2017-05-01 Kui Ren , Rongting Zhang

Photo-acoustic tomography is a coupled-physics (hybrid) medical imaging modality that aims to reconstruct optical parameters in biological tissues from ultrasound measurements. As propagating light gets partially absorbed, the resulting…

Analysis of PDEs · Mathematics 2020-01-08 Guillaume Bal , Adrian Kirkeby

Two-photon absorption photoacoustic tomography (TP-PAT) is a recent hybrid imaging modality that aims at reconstructing two-photon absorption properties of heterogeneous media from measured ultrasound signals generated by the photoacoustic…

Medical Physics · Physics 2018-03-14 Patrick Bardsley , Kui Ren , Rongting Zhang

Photoacoustic imaging systems offer a platform with high resolution to explore body tissues, food, and artwork. On the other hand, plasmonics constitutes a source of resonant heating and thermal expansion to generate acoustic waves.…

Applied Physics · Physics 2022-08-29 Ricardo Martín Abraham-Ekeroth

Quantitative photoacoustic tomography (qPAT) is an imaging technique aimed at estimating chromophore concentrations inside tissues from photoacoustic images, which are formed by combining optical information and ultrasonic propagation. The…

Computational Physics · Physics 2019-12-23 Hwan Goh , Timo Lahivaara , Tanja Tarvainen , Aki Pulkkinen , Owen Dillon , Ruanui Nicholson , Jari Kaipio

Existing approaches to image reconstruction in photoacoustic computed tomography (PACT) with acoustically heterogeneous media are limited to weakly varying media, are computationally burdensome, and/or cannot effectively mitigate the…

Medical Physics · Physics 2013-03-25 Chao Huang , Kun Wang , Liming Nie , Lihong V. Wang , Mark A. Anastasio

Photoacoustic tomography (PAT) combines the advantages of the spectroscopic optical absorption contrast and acoustic resolution with deep penetration, and becomes an important novel biomedical imaging technology for scientific research and…

Instrumentation and Detectors · Physics 2021-12-23 Daohuai Jiang , Yifei Xu , Hengrong Lan , Feng Gao , Fei Gao

Photoacoustic imaging (PAI) is a novel hybrid imaging technique that combines the benefits of both optical and acoustic imaging modalities, which provides functional and molecular optical contrasts of deep tissue. Commonly used ultrasound…

Medical Physics · Physics 2025-09-24 Xiyu Chen , Junxiang Cai , Rui Zheng , Tao Wu , Fei Gao

Optical imaging of blood flow yields critical functional insights into the circulatory system, but its clinical implementation has typically been limited to shallow depths (~1 millimeter) due to light scattering in biological tissue. Here,…

Medical Physics · Physics 2024-06-25 Yang Zhang , Joshua Olick-Gibson , Karteekeya Sastry , Lihong V. Wang

Photoacoustic computed tomography (PACT) is a hybrid imaging modality, which combines the high optical contrast of pure optical imaging and the high penetration depth of ultrasound imaging. However, photoacoustic image dataset with good…

Medical Physics · Physics 2022-05-24 Tengbo Lyu , Changchun Yang , Jiadong Zhang , Shanshan Guo , Feng Gao , Fei Gao

Current 3D photoacoustic tomography (PAT) systems offer either high image quality or high frame rates but are not able to deliver high spatial and temporal resolution simultaneously, which limits their ability to image dynamic processes in…

Numerical Analysis · Mathematics 2016-12-21 Simon Arridge , Paul Beard , Marta Betcke , Ben Cox , Nam Huynh , Felix Lucka , Olumide Ogunlade , Edward Zhang

Photoacoustic imaging (PAI) is an emerging biomedical imaging modality capable of providing both high contrast and high resolution of optical and UltraSound (US) imaging. When a short duration laser pulse illuminates the tissue as a target…

Signal Processing · Electrical Eng. & Systems 2018-01-19 Moein Mozaffarzadeh , Ali Mahloojifar , Mahdi Orooji

Accurate measurement of optical absorption coefficients from photoacoustic imaging (PAI) data would enable direct mapping of molecular concentrations, providing vital clinical insight. The ill-posed nature of the problem of absorption…

Image and Video Processing · Electrical Eng. & Systems 2023-06-13 Janek Gröhl , Thomas R. Else , Lina Hacker , Ellie V. Bunce , Paul W. Sweeney , Sarah E. Bohndiek

Improving the efficiency of photothermal (PT) therapies and photoacoustic (PA) imaging at the microscopic scale hinges on developing multiphoton-absorbing photothermal molecules or contrast agents that operate in the near-infrared (NIR)…

Optoacoustic (OA) imaging is based on excitation of biological tissues with nanosecond-duration laser pulses followed by subsequent detection of ultrasound waves generated via light-absorption-mediated thermoelastic expansion. OA imaging…

Image and Video Processing · Electrical Eng. & Systems 2023-05-04 Firat Ozdemir , Berkan Lafci , Xosé Luís Deán-Ben , Daniel Razansky , Fernando Perez-Cruz