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In recent years, diffusion models trained on equilibrium molecular distributions have proven effective for sampling biomolecules. Beyond direct sampling, the score of such a model can also be used to derive the forces that act on molecular…

Machine Learning · Computer Science 2026-01-15 Michael Plainer , Hao Wu , Leon Klein , Stephan Günnemann , Frank Noé

Diffusion guidance is a powerful technique that enables controllable and high-fidelity sample generation with diffusion models. At a high level, it modifies the score function by incorporating a guidance term that steers the generative…

Machine Learning · Computer Science 2026-05-25 Ruijia Cao , Yuchen Wu , Nisha Chandramoorthy

We present Diffusion Soup, a compartmentalization method for Text-to-Image Generation that averages the weights of diffusion models trained on sharded data. By construction, our approach enables training-free continual learning and…

Computer Vision and Pattern Recognition · Computer Science 2024-06-13 Benjamin Biggs , Arjun Seshadri , Yang Zou , Achin Jain , Aditya Golatkar , Yusheng Xie , Alessandro Achille , Ashwin Swaminathan , Stefano Soatto

Training neural samplers directly from unnormalized densities without access to target distribution samples presents a significant challenge. A critical desideratum in these settings is achieving comprehensive mode coverage, ensuring the…

Machine Learning · Computer Science 2025-05-27 Chenguang Wang , Xiaoyu Zhang , Kaiyuan Cui , Weichen Zhao , Yongtao Guan , Tianshu Yu

Psychiatric neuroscience is increasingly aware of the need to define psychopathology in terms of abnormal neural computation. The central tool in this endeavour is the fitting of computational models to behavioural data. The most prominent…

Quantitative Methods · Quantitative Biology 2018-03-28 Abraham Nunes , Alexander Rudiuk

The widespread use of diffusion models has led to an abundance of AI-generated data, raising concerns about model collapse -- a phenomenon in which recursive iterations of training on synthetic data lead to performance degradation. Prior…

Machine Learning · Computer Science 2025-12-29 Lianghe Shi , Meng Wu , Huijie Zhang , Zekai Zhang , Molei Tao , Qing Qu

Score-based models have achieved remarkable results in the generative modeling of many domains. By learning the gradient of smoothed data distribution, they can iteratively generate samples from complex distribution e.g. natural images.…

Artificial Intelligence · Computer Science 2024-03-27 Binxu Wang , John J. Vastola

Score-based diffusion models, while achieving minimax optimality for sampling, are often hampered by slow sampling speeds due to the high computational burden of score function evaluations. Despite the recent remarkable empirical advances…

Machine Learning · Computer Science 2025-02-27 Gen Li , Changxiao Cai

Score matching is an estimation procedure that has been developed for statistical models whose probability density function is known up to proportionality but whose normalizing constant is intractable, so that maximum likelihood is…

Methodology · Statistics 2024-04-23 Jiazhen Xu , Janice L. Scealy , Andrew T. A. Wood , Tao Zou

Video summarization aims to eliminate visual redundancy while retaining key parts of video to construct concise and comprehensive synopses. Most existing methods use discriminative models to predict the importance scores of video frames.…

Computer Vision and Pattern Recognition · Computer Science 2024-12-13 Zirui Shang , Yubo Zhu , Hongxi Li , Shuo Yang , Xinxiao Wu

Model-based reinforcement learning (MBRL) has gained much attention for its ability to learn complex behaviors in a sample-efficient way: planning actions by generating imaginary trajectories with predicted rewards. Despite its success, we…

Machine Learning · Computer Science 2024-02-20 Vint Lee , Pieter Abbeel , Youngwoon Lee

We consider the problem of parameter estimation for a class of continuous-time state space models. In particular, we explore the case of a partially observed diffusion, with data also arriving according to a diffusion process. Based upon a…

Computation · Statistics 2021-03-16 Alexandros Beskos , Dan Crisan , Ajay Jasra , Nikolas Kantas , Hamza Ruzayqat

We study the problem of training diffusion and flow generative models to sample from target distributions defined by an exponential tilting of a base density; a formulation that subsumes both sampling from unnormalized densities and reward…

Machine Learning · Statistics 2026-05-04 Carles Domingo-Enrich , Yuanqi Du , Michael S. Albergo

Machine learning systems such as large scale recommendation systems or natural language processing systems are usually trained on billions of training points and are associated with hundreds of billions or trillions of parameters. Improving…

Machine Learning · Computer Science 2023-05-26 Michael Kounavis , Ousmane Dia , Ilqar Ramazanli

Score-based Generative Models (SGMs) have demonstrated remarkable generalization abilities, e.g. generating unseen, but natural data. However, the greater the generalization power, the more likely the unintended generalization, and the more…

Machine Learning · Computer Science 2025-06-27 Wan Jiang , He Wang , Xin Zhang , Dan Guo , Zhaoxin Fan , Yunfeng Diao , Richang Hong

While autoregressive models excel at image compression, their sample quality is often lacking. Although not realistic, generated images often have high likelihood according to the model, resembling the case of adversarial examples. Inspired…

Machine Learning · Computer Science 2021-03-30 Chenlin Meng , Jiaming Song , Yang Song , Shengjia Zhao , Stefano Ermon

Denoising diffusion probabilistic models are able to generate synthetic sensor signals. The training process of such a model is controlled by a loss function which measures the difference between the noise that was added in the forward…

Machine Learning · Computer Science 2025-11-27 Heiko Oppel , Andreas Spilz , Michael Munz

Data noising is an effective technique for regularizing neural network models. While noising is widely adopted in application domains such as vision and speech, commonly used noising primitives have not been developed for discrete…

Machine Learning · Computer Science 2017-03-09 Ziang Xie , Sida I. Wang , Jiwei Li , Daniel Lévy , Aiming Nie , Dan Jurafsky , Andrew Y. Ng

Score-based diffusion models are a powerful class of generative models, but their practical use often depends on training neural networks to approximate the score function. Training-free diffusion models provide an attractive alternative by…

Numerical Analysis · Mathematics 2026-01-28 Pengjun Wang , Zezhong Zhang , Minglei Yang , Feng Bao , Yanzhao Cao , Guannan Zhang

Score-based diffusion models have emerged as powerful techniques for generating samples from high-dimensional data distributions. These models involve a two-phase process: first, injecting noise to transform the data distribution into a…

Machine Learning · Computer Science 2024-10-21 Runjia Li , Qiwei Di , Quanquan Gu