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Feedback-based quantum algorithms have recently emerged as potential methods for approximating the ground states of Hamiltonians. One such algorithm, the feedback-based algorithm for quantum optimization (FALQON), is specifically designed…

Quantum Physics · Physics 2025-08-18 Salahuddin Abdul Rahman , Özkan Karabacak , Rafal Wisniewski

The Feedback-based Algorithm for Quantum Optimization (FALQON) is a Lyapunov inspired quantum algorithm proposed to tackle combinatorial optimization problems. In this paper, we examine the robustness of FALQON against coherent control…

Systems and Control · Electrical Eng. & Systems 2025-09-29 Mirko Legnini , Julian Berberich

Drug-drug interactions (DDIs) are a leading cause of preventable adverse events, often complicating treatment and increasing healthcare costs. At the same time, knowing which drugs do not interact is equally important, as such knowledge…

Machine Learning · Computer Science 2026-01-08 Maryam Abdollahi Shamami , Babak Teimourpour , Farshad Sharifi

Quantum optimization, both for classical and quantum functions, is one of the most well-studied applications of quantum computing, but recent trends have relied on hybrid methods that push much of the fine-tuning off onto costly classical…

Quantum Physics · Physics 2024-09-25 Lucas T. Brady , Stuart Hadfield

The feedback-based algorithm for quantum optimization (FALQON) has recently been proposed to solve quadratic unconstrained binary optimization problems. This paper efficiently generalizes FALQON to tackle quadratic constrained binary…

Quantum Physics · Physics 2025-04-15 Salahuddin Abdul Rahman , Özkan Karabacak , Rafal Wisniewski

Drug-drug interaction (DDI) prediction is a critical task in computational biomedicine, as adverse interactions between co-administered drugs can cause severe side effects and clinical risks. A key challenge is unseen-drug generalization,…

Machine Learning · Computer Science 2026-05-15 Yerin Park , Sangseon Lee

In contrast to the classical optimization process required by the quantum approximate optimization algorithm, FALQON, a feedback-based algorithm for quantum optimization [A. B. Magann {\it et al.,} {\color{blue}Phys. Rev. Lett. {\bf129},…

Quantum Physics · Physics 2024-06-12 S. X. Li , W. L. Mu , J. B. You , X. Q. Shao

In Oncology, trials evaluating drug combinations are becoming more common. While combination therapies bring the potential for greater efficacy, they also create unique challenges for ensuring drug safety. In Phase-I dose escalation trials…

Applications · Statistics 2023-02-23 Lukas A. Widmer , Andrew Bean , David Ohlssen , Sebastian Weber

Drug combinations are essential in cancer therapy, leveraging synergistic drug-drug interactions (DDI) to enhance efficacy and combat resistance. However, the vast combinatorial space makes experimental screening impractical, and existing…

Machine Learning · Computer Science 2026-03-26 Yuxuan Nie , Yutong Song , Jinjie Yang , Yupeng Song , Yujue Zhou , Hong Peng

Cell heterogeneity plays an important role in patient responses to drug treatments. In many cancers, it is associated with poor treatment outcomes. Many modern drug combination therapies aim to exploit cell heterogeneity, but determining…

Quantitative Methods · Quantitative Biology 2025-02-18 Simon F. Martina-Perez , Samuel W. S. Johnson , Rebecca M. Crossley , Jennifer C. Kasemeier , Paul M. Kulesa , Ruth E. Baker

The importance of feedback control is being increasingly appreciated in quantum physics and applications. This paper describes the use of optimal control methods in the design of quantum feedback control systems, and in particular the paper…

Quantum Physics · Physics 2009-11-10 M. R. James

Hybrid quantum-classical algorithms hold great promise for solving quantum control problems on near-term quantum computers. In this work, we employ the hybrid framework that integrates digital quantum simulation with classical optimization…

Quantum Physics · Physics 2025-07-01 Tangyou Huang , Jing-Jun Zhu , Zhong-Yi Ni

Feedback-based quantum optimization is a quantum approach to combinatorial optimization. In this paper, we introduce the classical counterpart of feedback-based quantum optimization by using the quantum-classical correspondence of spin…

Quantum Physics · Physics 2026-05-14 Tomohiro Hattori , Takuya Hatomura

Drug-drug interactions (DDIs) are a major concern in polypharmacy. Public databases often provide only qualitative descriptions without pharmacokinetic context. We present an interactive web tool that integrates 191,541 descriptive DDI…

Quantitative Methods · Quantitative Biology 2025-08-13 Nadezhda Diadkina

Optimizing the controls of quantum systems plays a crucial role in advancing quantum technologies. The time-varying noises in quantum systems and the widespread use of inhomogeneous quantum ensembles raise the need for high-quality quantum…

Quantum Physics · Physics 2025-05-06 Xinyu Fei , Lucas T. Brady , Jeffrey Larson , Sven Leyffer , Siqian Shen

This paper studies optimal consensus tracking problem of heterogeneous linear multi-agent systems. By introducing tracking error dynamics, the optimal tracking problem is reformulated as finding a Nash-equilibrium solution of a multi-player…

Optimization and Control · Mathematics 2019-05-21 Jilie Zhang , Zhanshan Wang , Hongwei Zhang

Drug-Drug Interactions (DDIs) significantly influence therapeutic efficacy and patient safety. As experimental discovery is resource-intensive and time-consuming, efficient computational methodologies have become essential. The predominant…

Machine Learning · Computer Science 2026-02-03 Xinmo Jin , Bowen Fan , Xunkai Li , Henan Sun , YuXin Zeng , Zekai Chen , Yuxuan Sun , Jia Li , Qiangqiang Dai , Hongchao Qin , Rong-Hua Li , Guoren Wang

This paper proposes a quantum framework for the design of communication topologies in consensus-based multi-agent systems. The communication graph is selected online by solving a mixed-integer quadratic program (MIQP) that minimizes a cost…

Systems and Control · Electrical Eng. & Systems 2026-02-09 Milad Hasanzadeh , Amin Kargarian

It is hoped that quantum computers will offer advantages over classical computers for combinatorial optimization. Here, we introduce a feedback-based strategy for quantum optimization, where the results of qubit measurements are used to…

Quantum Physics · Physics 2023-01-05 Alicia B. Magann , Kenneth M. Rudinger , Matthew D. Grace , Mohan Sarovar

Interference between pharmacological substances can cause serious medical injuries. Correctly predicting so-called drug-drug interactions (DDI) does not only reduce these cases but can also result in a reduction of drug development cost.…

Machine Learning · Computer Science 2019-08-06 Md. Rezaul Karim , Michael Cochez , Joao Bosco Jares , Mamtaz Uddin , Oya Beyan , Stefan Decker
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