Related papers: Chemotactic Feedback Controls Patterning in Hybrid…
In this work we analyse a PDE-ODE problem modelling the evolution of a Glioblastoma, which includes an anisotropic nonlinear diffusion term with a diffusion velocity increasing with respect to vasculature. First, we prove the existence of…
This paper presents a backstepping solution for the output feedback control of general linear heterodirectional hyperbolic PDE-ODE systems with spatially-varying coefficients. Thereby, the coupling in the PDE is in-domain and at the…
We propose a diffuse interface model to describe tumor as a multicomponent deformable porous medium. We include mechanical effects in the model by coupling the mass balance equations for the tumor species and the nutrient dynamics to a…
This paper is concerned with the well-posedness and large-time behavior of a two dimensional PDE-ODE hybrid chemotaxis system describing the initiation of tumor angiogenesis. We first transform the system via a Cole-Hopf type transformation…
We study coupled mass transport in a tumor--microenvironment setting with two motile densities $(S,R)$ and non-motile state switching $(P,A)$. The populations diffuse and undergo chemotactic drift; $(P,A)$ follow pointwise ODE switching. A…
We consider a diffuse interface model for tumor growth recently proposed in [Y. Chen, S.M. Wise, V.B. Shenoy, J.S. Lowengrub, A stable scheme for a nonlinear, multiphase tumor growth model with an elastic membrane, Int. J. Numer. Methods…
We present a mathematical analysis of a mixed ODE-PDE model describing the spatial distribution and temporal evolution of tumor and normal cells within a tissue subject to the effects of a chemotherapeutic drug. The model assumes that the…
Reaction-diffusion models are used to describe systems in fields as diverse as physics, chemistry, ecology and biology. The fundamental quantities in such models are individual entities such as atoms and molecules, bacteria, cells or…
We develop a control design for stabilization of traffic flow in congested regime, based on an Aw-Rascle-Zhang-type (ARZ-type) Partial Differential Equation (PDE) model, for traffic consisting of both ACC-equipped (Adaptive Cruise…
This paper presents a mathematical framework for optimizing drug delivery in cancer treatment using a nonlocal model of solid tumor growth. We present a coupled system of partial differential equations that incorporate long-range cellular…
We develop a novel multi-layer predictor-feedback to achieve exact compensation of state-dependent input delay of general nonlinear integro-differential equations. The system of interest is an unconventional mixed Partial Differential…
Estimating counterfactual outcomes over time has the potential to unlock personalized healthcare by assisting decision-makers to answer ''what-iF'' questions. Existing causal inference approaches typically consider regular, discrete-time…
This paper deals with the backstepping design of observer-based compensators for parabolic ODE-PDE-ODE systems. The latter consist of n coupled parabolic PDEs with distinct diffusion coefficients and spatially-varying coefficients, that are…
In this work we analyse a PDE-ODE problem modelling the evolution of a Glioblastoma, which includes chemotaxis term directed to vasculature. First, we obtain some a priori estimates for the (possible) solutions of the model. In particular,…
We present a control design for semilinear and quasilinear 2x2 hyperbolic partial differential equations with the control input at one boundary and a nonlinear ordinary differential equation coupled to the other. The controller can be…
Stochastic simulation methods can be applied successfully to model exact spatio-temporally resolved reaction-diffusion systems. However, in many cases, these methods can quickly become extremely computationally intensive with increasing…
This work concerns the exponential stabilization of underactuated linear homogeneous systems of m parabolic partial differential equations (PDEs) in cascade (reaction-diffusion systems), where only the first state is controlled either…
In this paper, we study the global dynamics of a general reaction-diffusion model based on acid-mediated invasion hypothesis, which is a candidate explanation for the Warburg effect. A key feature of this model is the density-limited tumor…
We consider an evolutionary PDE system coupling the Cahn-Hilliard equation with singular potential, mass source and transport effects, to a Brinkman-type relation for the macroscopic velocity field and to a further equation describing the…
We consider an interlinked production model consisting of conservation laws (PDE) coupled to ordinary differential equations (ODE). Our focus is the analysis of control laws for the coupled system and corresponding stabilization questions…