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We analyze a class of cell-bulk coupled PDE-ODE models, motivated by quorum and diffusion sensing phenomena in microbial systems, that characterize communication between localized spatially segregated dynamically active signaling…

Pattern Formation and Solitons · Physics 2020-07-20 Sarafa A. Iyaniwura , Michael J. Ward

In this paper, we are concerned with the state feedback stabilization of ODE-PDE cascade systems governed by a linear ordinary differential equation and the 1-d reaction-diffusion equation posed on a bounded interval. In contrast to the…

Analysis of PDEs · Mathematics 2018-01-04 Habib Ayadi

We solve the global asymptotic stability problem of an unstable reaction-diffusion Partial Differential Equation (PDE) subject to input delay and state quantization developing a switched predictor-feedback law. To deal with the input delay,…

Systems and Control · Electrical Eng. & Systems 2025-01-28 Florent Koudohode , Nikolaos Bekiaris-Liberis

A novel approach to design the feedback control based on past states is proposed for hybrid stochastic differential equations (HSDEs). This new theorem builds up the connection between the delay feedback control and the control function…

Optimization and Control · Mathematics 2019-07-30 Junhao Hu , Wei Liu , Feiqi Deng , Xuerong Mao

In this article, we investigate the problem of exponential stabilization via output feedback for a cascaded system composed of an ordinary differential equation (ODE) and a wave partial differential equation (PDE) under boundary control.…

Optimization and Control · Mathematics 2026-05-12 Zhan-Dong Mei , Lan-Xi Tang

We propose a variational framework for solving ground-state problems of open quantum systems governed by quantum stochastic differential equations (QSDEs). This formulation naturally accommodates bosonic operators, as commonly encountered…

Quantum Physics · Physics 2025-12-17 Yunyan Lee , Ian R. Petersen , Daoyi Dong

Oncolytic virotherapy, utilizing genetically modified viruses to combat cancer and trigger anti-cancer immune responses, has garnered significant attention in recent years. In our previous work arXiv:2305.12386, we developed a stochastic…

Populations and Evolution · Quantitative Biology 2026-04-23 David Morselli , Marcello E. Delitala , Adrianne L. Jenner , Federico Frascoli

We introduce a set of ordinary differential equations (ODE) that qualitatively reproduces delayed responses observed in immune checkpoint blockade therapy (e.g. anti-CTLA-4 Ipilimumab). This type of immunotherapy has been at the forefront…

Dynamical Systems · Mathematics 2021-10-07 Collin Y. Zheng , Peter S. Kim

Intratumour phenotypic heterogeneity is nowadays understood to play a critical role in disease progression and treatment failure. Accordingly, there has been increasing interest in the development of mathematical models capable of capturing…

Populations and Evolution · Quantitative Biology 2025-04-10 Chiara Villa , Philip K Maini , Alexander P Browning , Adrianne L Jenner , Sara Hamis , Tyler Cassidy

We consider the inverse problem of identifying parameters in a variant of the diffuse interface model for tumour growth model proposed by Garcke, Lam, Sitka and Styles (Math. Models Methods Appl. Sci. 2016). The model contains three…

Optimization and Control · Mathematics 2017-07-24 Christian Kahle , Kei Fong Lam

We develop backstepping state feedback control to stabilize a moving shockwave in a freeway segment under bilateral boundary actuations of traffic flow. A moving shockwave, consisting of light traffic upstream of the shockwave and heavy…

Optimization and Control · Mathematics 2019-04-10 Huan Yu , Mamadou Diagne , Liguo Zhang , Miroslav Krstic

The chemotaxis PDE system with singular sensitivity was originally proposed by Short et al. (Math. Mod. Meth. Appl. Sci., 2008) as the continuum limit of a biased random walk model to account for the formation of crime hotspots and…

Numerical Analysis · Mathematics 2026-03-17 Rui Wang , Yunfeng Xiong , Zhengru Zhang

We investigate the long-time dynamics and optimal control problem of a diffuse interface model that describes the growth of a tumor in presence of a nutrient and surrounded by host tissues. The state system consists of a Cahn-Hilliard type…

Analysis of PDEs · Mathematics 2023-07-28 Cecilia Cavaterra , Elisabetta Rocca , Hao Wu

We study a distributed optimal control problem for a nonisothermal Caginalp-type phase-field model that describes tumour growth under thermal therapy. The PDE system couples a possibly viscous Cahn-Hilliard equation, governing the evolution…

Optimization and Control · Mathematics 2026-05-05 Giulia Cavalleri , Pierluigi Colli , Elisabetta Rocca

Feedback control in open quantum dynamics is crucial for the advancement of various coherent platforms. However, currently only a handful of feedback master equations exist in the literature, which are restricted to specific types of…

Quantum Physics · Physics 2025-12-10 Alberto J. B. Rosal , Patrick P. Potts , Gabriel T. Landi

Partial differential equation (PDE) models for infectious diseases, while less common than their ordinary differential equation (ODE) counterparts, have found successful applications for many years. Such models are typically of…

Populations and Evolution · Quantitative Biology 2026-01-27 Alex Viguerie , Malú Grave , Alvaro L. G. A. Coutinho , Alessandro Veneziani , Thomas J. R. Hughes

This paper addresses the derivation of generic and tractable sufficient conditions ensuring the stability of a coupled system composed of a reaction-diffusion partial differential equation (PDE) and a finite-dimensional linear time…

Optimization and Control · Mathematics 2022-07-20 Hugo Lhachemi , Christophe Prieur

In this paper, we study a semilinear parabolic PDE system which describes the interaction of normal cells, tumor cells, immune cells, with a chemotherapeutic drug. The model extends the previous model with incorporating strong Allee affects…

Analysis of PDEs · Mathematics 2026-02-05 Xiaoqin Liu , Hong-Ming Yin

Impulse-to-peak response (I2P) analysis for state-space ordinary differential equation (ODE) systems is a well-studied classical problem. However, the techniques employed for I2P optimal control of ODEs have not been extended to partial…

Optimization and Control · Mathematics 2026-04-07 Tristan Thomas , Sachin Shivakumar , Javad Mohammadpour Velni

A widely used approach to describe the dynamics of gene regulatory networks is based on the chemical master equation, which considers probability distributions over all possible combinations of molecular counts. The analysis of such models…

Molecular Networks · Quantitative Biology 2019-06-04 Pavel Kurasov , Alexander Lück , Delio Mugnolo , Verena Wolf