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Multimodal large language models (MLLMs) have shown great potential in medical applications, yet existing benchmarks inadequately capture real-world clinical complexity. We introduce MEDSYN, a multilingual, multimodal benchmark of highly…

Computation and Language · Computer Science 2026-04-20 Boqi Chen , Xudong Liu , Jiachuan Peng , Marianne Frey-Marti , Bang Zheng , Kyle Lam , Lin Li , Jianing Qiu

Multi-contrast images are commonly acquired together to maximize complementary diagnostic information, albeit at the expense of longer scan times. A time-efficient strategy to acquire high-quality multi-contrast images is to accelerate…

In this study, we develop a physics-informed deep learning-based method to synthesize multiple brain magnetic resonance imaging (MRI) contrasts from a single five-minute acquisition and investigate its ability to generalize to arbitrary…

Motivation. Understanding the pan-cancer mutational landscape offers critical insights into the molecular mechanisms underlying tumorigenesis. While patient-level machine learning techniques have been widely employed to identify tumor…

Machine Learning · Computer Science 2025-08-29 Yifan Dou , Adam Khadre , Ruben C Petreaca , Golrokh Mirzaei

Computed tomography (CT) and clinical numeric data are essential modalities for cancer evaluation, but building large-scale multimodal training datasets for developing medical foundation models remains challenging due to the structural…

Computer Vision and Pattern Recognition · Computer Science 2025-01-24 Daeun Jung , Jaehyeok Jang , Sooyoung Jang , Yu Rang Park

Magnetic resonance imaging (MRI) plays a vital role in clinical diagnostics, yet it remains hindered by long acquisition times and motion artifacts. Multi-contrast MRI reconstruction has emerged as a promising direction by leveraging…

Computer Vision and Pattern Recognition · Computer Science 2026-01-15 Xinming Fang , Chaoyan Huang , Juncheng Li , Jun Wang , Jun Shi , Guixu Zhang

Recently, medical image synthesis gains more and more popularity, along with the rapid development of generative models. Medical image synthesis aims to generate an unacquired image modality, often from other observed data modalities.…

Image and Video Processing · Electrical Eng. & Systems 2025-07-04 Zhe Xiong , Qiaoqiao Ding , Xiaoqun Zhang

Diffusion models have achieved remarkable quality in multi-modal MRI synthesis, but their computational cost (hundreds of sampling steps and separate models per modality) limits clinical deployment. We observe that this inefficiency stems…

Computer Vision and Pattern Recognition · Computer Science 2026-04-24 Yalcin Tur , Mihajlo Stojkovic , Ulas Bagci

Image matching for both cross-view and cross-modality plays a critical role in multimodal perception. In practice, the modality gap caused by different imaging systems/styles poses great challenges to the matching task. Existing works try…

Computer Vision and Pattern Recognition · Computer Science 2025-04-01 Jiangwei Ren , Xingyu Jiang , Zizhuo Li , Dingkang Liang , Xin Zhou , Xiang Bai

Contrastive representation learning is crucial in medical time series analysis as it alleviates dependency on labor-intensive, domain-specific, and scarce expert annotations. However, existing contrastive learning methods primarily focus on…

Machine Learning · Computer Science 2023-11-07 Yihe Wang , Yu Han , Haishuai Wang , Xiang Zhang

An optical microscope enables image-based findings and diagnosis on microscopic targets, which is indispensable in many scientific, industrial and medical settings. Majority of microscope users are accustomed to standard benchtop…

Optics · Physics 2025-05-06 Keiichiro Toda , Miu Tamamitsu , Ryoichi Horisaki , Takuro Ideguchi

X-ray microtomography is a versatile tool allowing the measurement of the 3D structure of optically thick samples. As a non-destructive technique, it is readily adapted to 4D imaging, where a sample can be monitored over time, and…

Instrumentation and Detectors · Physics 2025-12-17 Harry Allan , Tom Partridge , Joseph Jacob , Marco Endrizzi

Multi contrast MRI synthesis is inherently challenging due to the complex and nonlinear relationships among different contrasts. Each MRI contrast highlights unique tissue properties, but their complementary information is difficult to…

Image and Video Processing · Electrical Eng. & Systems 2025-06-23 Sanuwani Dayarathna , Himashi Peiris , Kh Tohidul Islam , Tien-Tsin Wong , Zhaolin Chen

Accurate segmentation of brain images typically requires the integration of complementary information from multiple image modalities. However, clinical data for all modalities may not be available for every patient, creating a significant…

Computer Vision and Pattern Recognition · Computer Science 2025-05-20 Haitao Li , Ziyu Li , Yiheng Mao , Zhengyao Ding , Zhengxing Huang

Non-contrast CT (NCCT) imaging may reduce image contrast and anatomical visibility, potentially increasing diagnostic uncertainty. In contrast, contrast-enhanced CT (CECT) facilitates the observation of regions of interest (ROI). Leading…

Image and Video Processing · Electrical Eng. & Systems 2024-11-18 Tingyi Lin , Pengju Lyu , Jie Zhang , Yuqing Wang , Cheng Wang , Jianjun Zhu

Imaging of microvasculature is primarily performed with X-ray contrast agents, owing to the wide availability of absorption-contrast laboratory source microCT compared to phase contrast capable devices. Standard commercial contrast agents…

Tissues and Organs · Quantitative Biology 2023-01-18 Willy Kuo , Ngoc An Le , Bernhard Spingler , Georg Schulz , Bert Müller , Vartan Kurtcuoglu

Iodinated contrast media is essential for dual-energy computed tomography (DECT) angiography. Previous studies show that iodinated contrast media may cause side effects, and the interruption of the supply chain in 2022 led to a severe…

Image and Video Processing · Electrical Eng. & Systems 2023-08-28 Qing Lyu , Josh Tan , Megan E. Lipford , Chuang Niu , Micheal E. Zapadka , Christopher M. Lack , Jonathan D. Clemente , Christopher T. Whitlow , Ge Wang

Machine learning holds promise for advancing clinical decision support, yet it remains unclear when multimodal learning truly helps in practice, particularly under modality missingness and fairness constraints. In this work, we conduct a…

Machine Learning · Computer Science 2026-03-02 Kejing Yin , Haizhou Xu , Wenfang Yao , Chen Liu , Zijie Chen , Yui Haang Cheung , William K. Cheung , Jing Qin

Existing image contrast enhancement methods are typically designed for specific tasks such as under-/over-exposure correction, low-light and backlit image enhancement, etc. The learned models, however, exhibit poor generalization…

Computer Vision and Pattern Recognition · Computer Science 2025-07-24 Ruodai Cui , Lei Zhang