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The vision of Organic Computing addresses challenges that arise in the design of future information systems that are comprised of numerous, heterogeneous, resource-constrained and error-prone components or devices. Here, the notion organic…
We have evolved an IT system that is ubiquitous and pervasive and integrated into most aspects of our lives. Many of us are working on 4th and 5th level refinements in efficiency and functionality. But, we stand on the shoulders of those…
There has been on-going philosophical debate on whether artificial life models, also known as digital organisms, are truly alive. The main difficulty appears to be finding an encompassing and definite definition of life. By examining…
Future communication networks are expected to achieve deep integration of communication, sensing, and computation, forming a tightly coupled and autonomously operating infrastructure system. However, current reliance on centralized control,…
Mixed microbial communities, usually composed of various bacterial and fungal species, are fundamental in a plethora of environments, from soil to human gut and skin. Their evolution is a paradigmatic example of intertwined dynamics, where…
Technology is increasingly shaping our social structures and is becoming a driving force in altering human biology. Besides, human activities already proved to have a significant impact on the Earth system which in turn generates complex…
The field of single-cell biology is growing rapidly and is generating large amounts of data from a variety of species, disease conditions, tissues, and organs. Coordinated efforts such as CZI CELLxGENE, HuBMAP, Broad Institute Single Cell…
Cloud computing is the prevailing mode of designing, creating and deploying complex applications nowadays. Its underlying assumptions include distributed computing, but also new concepts that need to be incorporated in the different fields.…
We advocate here the use of computational logic for systems biology, as a \emph{unified and safe} framework well suited for both modeling the dynamic behaviour of biological systems, expressing properties of them, and verifying these…
We investigate the ability of a genetic algorithm to design cellular automata that perform computations. The computational strategies of the resulting cellular automata can be understood using a framework in which ``particles'' embedded in…
In this paper, we present a biologically grounded approach to reservoir computing (RC), in which a network of cultured biological neurons serves as the reservoir substrate. This system, referred to as biological reservoir computing (BRC),…
Understanding how the dynamics of neural networks is shaped by the computations they perform is a fundamental question in neuroscience. Recently, the framework of efficient coding proposed a theory of how spiking neural networks can compute…
We investigate an abstract conceptualisation of DigitalEcosystems from a computer science perspective. We then provide a conceptual framework for the cross pollination of ideas, concepts and understanding between different classes of…
The design and operation of systems are conventionally viewed as a sequential decision-making process that is informed by data from physical experiments and simulations. However, the integration of these high-dimensional and heterogeneous…
Computer simulations have become a very powerful tool for scientific research. In order to facilitate research in computational biology, the BioDynaMo project aims at a general platform for biological computer simulations, which should be…
In this paper we highlight the scopes of engineering bio-inspired political systems, which are political systems based on the properties of life that self-organize the increasing complexity of human social systems. We describe bio-inspired…
Higher-order interactions play a key role for the stability and function of a complex system. However, how to identify them is still an open problem. Here, we propose a method to fully reconstruct the structural connectivity of a system of…
System and synthetic biology are rapidly evolving systems, but both lack tools such as those used in engineering environments to shift the their focus from the design of parts (details) to the design of systems (behaviors); to aggravate,…
Naturally, humans use multiple modalities to convey information. The modalities are processed both sequentially and in parallel for communication in the human brain, this changes when humans interact with computers. Empowering computers…
Many real-world dynamic systems, both natural and artificial, are understood to be performing computations. For artificial dynamic systems, explicitly designed to perform computation - such as digital computers - by construction, we can…