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The application of machine learning to bioinformatics problems is well established. Less well understood is the application of bioinformatics techniques to machine learning and, in particular, the representation of non-biological data as…

Machine Learning · Computer Science 2013-02-18 Ajit Narayanan , Yi Chen

Quantum computing for the biological sciences is an area of rapidly growing interest, but specific industrial applications remain elusive. Quantum Markov chain Monte Carlo has been proposed as a method for accelerating a broad class of…

Antibiotic resistance presents a growing global health crisis, demanding new therapeutic strategies that target novel bacterial mechanisms. Recent advances in protein structure prediction and machine learning-driven molecule generation…

Biomolecules · Quantitative Biology 2025-05-22 Maximilian G. Schuh , Joshua Hesse , Stephan A. Sieber

Quantum Computing (QC) has gained immense popularity as a potential solution to deal with the ever-increasing size of data and associated challenges leveraging the concept of quantum random access memory (QRAM). QC promises quadratic or…

Quantum computing promises to revolutionize our understanding of the limits of computation, and its implications in cryptography have long been evident. Today, cryptographers are actively devising post-quantum solutions to counter the…

Quantum machine learning (QML) is rapidly transitioning from theoretical promise to practical relevance across data-intensive scientific domains. In this Review, we provide a structured overview of recent advances that bridge foundational…

Quantum Physics · Physics 2026-02-25 Vinit Singh , Amandeep Singh Bhatia , Mandeep Kaur Saggi , Manas Sajjan , Sabre Kais

Quantum machine learning (QML) continues to be an area of tremendous interest from research and industry. While QML models have been shown to be vulnerable to adversarial attacks much in the same manner as classical machine learning models,…

Machine Learning · Computer Science 2024-04-26 Maximilian Wendlinger , Kilian Tscharke , Pascal Debus

Recent work has shown that, when integrated with adversarial training, self-supervised pre-training can lead to state-of-the-art robustness In this work, we improve robustness-aware self-supervised pre-training by learning representations…

Computer Vision and Pattern Recognition · Computer Science 2020-10-27 Ziyu Jiang , Tianlong Chen , Ting Chen , Zhangyang Wang

Increasingly deeper integration of HPC resources and QPUs unveils new challenges in computer architecture and engineering. As a consequence, dependability arises again as a concern encompassing resilience, reproducibility and security. The…

Quantum Physics · Physics 2026-03-10 Santiago Núñez-Corrales

The development of quantum computational techniques has advanced greatly in recent years, parallel to the advancements in techniques for deep reinforcement learning. This work explores the potential for quantum computing to facilitate…

Quantum Physics · Physics 2020-08-31 Owen Lockwood , Mei Si

Quantum classifiers are vulnerable to adversarial attacks that manipulate their input classical or quantum data. A promising countermeasure is adversarial training, where quantum classifiers are trained by using an attack-aware, adversarial…

Quantum Physics · Physics 2025-04-25 Petros Georgiou , Aaron Mark Thomas , Sharu Theresa Jose , Osvaldo Simeone

This study evaluates colorectal risk factors and compares classical models against Quantum Neural Networks (QNNs) for anastomotic leak prediction. Analyzing clinical data with 14\% leak prevalence, we tested ZZFeatureMap encodings with…

Machine Learning · Computer Science 2026-04-16 Vojtěch Novák , Ivan Zelinka , Lenka Přibylová , Lubomír Martínek , Vladimír Benčurík , Martin Beseda

The widespread use of cloud-based medical devices and wearable sensors has made physiological data susceptible to tampering. These attacks can compromise the reliability of healthcare systems which can be critical and life-threatening.…

Quantum Physics · Physics 2025-02-11 Md. Saif Hassan Onim , Himanshu Thapliyal

The increasing number of cyber threats and rapidly evolving tactics, as well as the high volume of data in recent years, have caused classical machine learning, rules, and signature-based defence strategies to fail, rendering them unable to…

Machine Learning · Computer Science 2025-12-18 Siva Sai , Ishika Goyal , Shubham Sharma , Sri Harshita Manuri , Vinay Chamola , Rajkumar Buyya

AlphaFold has achieved groundbreaking advancements in protein structure prediction, exerting profound influence across biology, medicine, and drug discovery. However, its reliance on multiple sequence alignment (MSA) is inherently…

Quantum Physics · Physics 2025-06-03 Rong Chen , Quan-Xin Mei , Wen-Ding Zhao , Lin Yao , Hao-Xiang Yang , Shun-Yao Zhang , Jiao Chen , Hong-Lin Li

Quantum data access and quantum processing can make certain classically intractable learning tasks feasible. However, quantum capabilities will only be available to a select few in the near future. Thus, reliable schemes that allow…

Quantum Physics · Physics 2024-02-07 Matthias C. Caro , Marcel Hinsche , Marios Ioannou , Alexander Nietner , Ryan Sweke

Quantitative Structure-Activity Relationship (QSAR) modeling is a cornerstone of computational drug discovery. This research demonstrates the successful application of a Quantum Multiple Kernel Learning (QMKL) framework to enhance QSAR…

Quantum Physics · Physics 2025-12-17 Alejandro Giraldo , Daniel Ruiz , Mariano Caruso , Javier Mancilla , Guido Bellomo

Anomaly Detection (AD) is critical in data analysis, particularly within the domain of IT security. In this study, we explore the potential of Quantum Machine Learning for application to AD with special focus on the robustness to noise and…

Quantum Physics · Physics 2026-05-14 Kilian Tscharke , Maximilian Wendlinger , Sebastian Issel , Pascal Debus

Qualitative structure-activity relationship (QSAR) is important for drug discovery and offers valuable insights into the biological interactions of potential drug candidates. It has been demonstrated that QSAR can be accurately predicted by…

Quantum Physics · Physics 2025-01-24 Wei-Yin Chiang , Po-Yu Kao , Tzu-Lan Yeh , Ya-Chu Yang , Yen-Chu Lin , Alex Zhavoronkov

We investigate the potential of patent data for improving the antibody humanness prediction using a multi-stage, multi-loss training process. Humanness serves as a proxy for the immunogenic response to antibody therapeutics, one of the…

Quantitative Methods · Quantitative Biology 2024-06-11 Talip Ucar , Aubin Ramon , Dino Oglic , Rebecca Croasdale-Wood , Tom Diethe , Pietro Sormanni
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