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Large Language Models (LLMs) have significantly advanced medical question-answering by leveraging extensive clinical data and medical literature. However, the rapid evolution of medical knowledge and the labor-intensive process of manually…

Computation and Language · Computer Science 2025-07-01 Mohammad Reza Rezaei , Reza Saadati Fard , Jayson L. Parker , Rahul G. Krishnan , Milad Lankarany

The vast amount of biomedical information available today presents a significant challenge for investigators seeking to digest, process, and understand these findings effectively. Large Language Models (LLMs) have emerged as powerful tools…

Computation and Language · Computer Science 2024-07-19 Alexander R. Pelletier , Joseph Ramirez , Irsyad Adam , Simha Sankar , Yu Yan , Ding Wang , Dylan Steinecke , Wei Wang , Peipei Ping

Technology-enhanced learning environments often help students retrieve relevant learning content for questions arising during self-paced study. Large language models (LLMs) have emerged as novel aids for information retrieval during…

Information Retrieval · Computer Science 2025-09-29 Eason Chen , Chuangji Li , Shizhuo Li , Zimo Xiao , Jionghao Lin , Kenneth R. Koedinger

To tackle the problem of domain-specific knowledge scarcity within large language models (LLMs), knowledge graph-retrievalaugmented method has been proven to be an effective and efficient technique for knowledge infusion. However, existing…

Computation and Language · Computer Science 2024-06-07 Zhouyu Jiang , Ling Zhong , Mengshu Sun , Jun Xu , Rui Sun , Hui Cai , Shuhan Luo , Zhiqiang Zhang

Generative AI, such as Large Language Models (LLMs), has achieved impressive progress but still produces hallucinations and unverifiable claims, limiting reliability in sensitive domains. Retrieval-Augmented Generation (RAG) improves…

Improving the performance of large language models (LLMs) in complex question-answering (QA) scenarios has always been a research focal point. Recent studies have attempted to enhance LLMs' performance by combining step-wise planning with…

Computation and Language · Computer Science 2024-10-24 Junjie Wang , Mingyang Chen , Binbin Hu , Dan Yang , Ziqi Liu , Yue Shen , Peng Wei , Zhiqiang Zhang , Jinjie Gu , Jun Zhou , Jeff Z. Pan , Wen Zhang , Huajun Chen

The rapid expansion of publicly-available medical data presents a challenge for clinicians and researchers alike, increasing the gap between the volume of scientific literature and its applications. The steady growth of studies and findings…

Artificial Intelligence · Computer Science 2025-08-06 Taine J. Elliott , Stephen P. Levitt , Ken Nixon , Martin Bekker

Knowledge Graphs (KGs) represent human-crafted factual knowledge in the form of triplets (head, relation, tail), which collectively form a graph. Question Answering over KGs (KGQA) is the task of answering natural questions grounding the…

Computation and Language · Computer Science 2024-05-31 Costas Mavromatis , George Karypis

Retrieval-augmented generation (RAG) enables large language models (LLMs) to dynamically access external information, which is powerful for answering questions over previously unseen documents. Nonetheless, they struggle with high-level…

Artificial Intelligence · Computer Science 2026-04-21 Chi-Hsiang Hsiao , Yi-Cheng Wang , Tzung-Sheng Lin , Yi-Ren Yeh , Chu-Song Chen

Large pre-trained language models have been shown to store factual knowledge in their parameters, and achieve state-of-the-art results when fine-tuned on downstream NLP tasks. However, their ability to access and precisely manipulate…

Electronic health records (EHRs) enable strong clinical prediction, but explanations are often coarse and hard to use for patient-level decisions. We propose a knowledge graph (KG)-guided chain-of-thought (CoT) framework for visit-level…

Artificial Intelligence · Computer Science 2026-03-03 Ruiyu Wang , Tuan Vinh , Ran Xu , Yuyin Zhou , Jiaying Lu , Carl Yang , Francisco Pasquel

Retrieval-Augmented Generation (RAG) has emerged as a prominent method for incorporating domain knowledge into Large Language Models (LLMs). While RAG enhances response relevance by incorporating retrieved domain knowledge in the context,…

Computation and Language · Computer Science 2025-03-28 Kushagra Bhushan , Yatin Nandwani , Dinesh Khandelwal , Sonam Gupta , Gaurav Pandey , Dinesh Raghu , Sachindra Joshi

Retrieval-Augmented Generation (RAG) mitigates hallucination in Large Language Models (LLMs) by incorporating external data, with Knowledge Graphs (KGs) offering crucial information for question answering. Traditional Knowledge Graph…

Computation and Language · Computer Science 2025-09-08 Yushi Sun , Kai Sun , Yifan Ethan Xu , Xiao Yang , Xin Luna Dong , Nan Tang , Lei Chen

Biomedical knowledge graphs (KGs) hold rich information on entities such as diseases, drugs, and genes. Predicting missing links in these graphs can boost many important applications, such as drug design and repurposing. Recent work has…

Computation and Language · Computer Science 2021-09-22 Rahul Nadkarni , David Wadden , Iz Beltagy , Noah A. Smith , Hannaneh Hajishirzi , Tom Hope

Recent advances in large language models (LLMs) have led to impressive progress in natural language generation, yet their tendency to produce hallucinated or unsubstantiated content remains a critical concern. To improve factual…

Computation and Language · Computer Science 2025-05-20 Xukai Liu , Ye Liu , Shiwen Wu , Yanghai Zhang , Yihao Yuan , Kai Zhang , Qi Liu

Retrieval-Augmented Generation (RAG) systems enable large language models (LLMs) instant access to relevant information for the generative process, demonstrating their superior performance in addressing common LLM challenges such as…

Computation and Language · Computer Science 2025-10-17 Yilun Zheng , Dan Yang , Jie Li , Lin Shang , Lihui Chen , Jiahao Xu , Sitao Luan

Knowledge graph completion (KGC) aims to predict missing triples in knowledge graphs (KGs) by leveraging existing triples and textual information. Recently, generative large language models (LLMs) have been increasingly employed for graph…

Artificial Intelligence · Computer Science 2025-11-11 Yongkang Xiao , Sinian Zhang , Yi Dai , Huixue Zhou , Jue Hou , Jie Ding , Rui Zhang

Large Language Models (LLMs) are proficient at generating coherent and contextually relevant text but face challenges when addressing knowledge-intensive queries in domain-specific and factual question-answering tasks. Retrieval-augmented…

Information Retrieval · Computer Science 2024-10-08 Garima Agrawal , Tharindu Kumarage , Zeyad Alghamdi , Huan Liu

Knowledge-intensive tasks pose a significant challenge for Machine Learning (ML) techniques. Commonly adopted methods, such as Large Language Models (LLMs), often exhibit limitations when applied to such tasks. Nevertheless, there have been…

Machine Learning · Computer Science 2024-05-20 Albert Sawczyn , Jakub Binkowski , Piotr Bielak , Tomasz Kajdanowicz

Large language models with retrieval-augmented generation encounter a pivotal challenge in intricate retrieval tasks, e.g., multi-hop question answering, which requires the model to navigate across multiple documents and generate…

Information Retrieval · Computer Science 2025-05-06 Weijie Chen , Ting Bai , Jinbo Su , Jian Luan , Wei Liu , Chuan Shi
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