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Segmentation of pathological images is essential for accurate disease diagnosis. The quality of manual labels plays a critical role in segmentation accuracy; yet, in practice, the labels between pathologists could be inconsistent, thus…

Image and Video Processing · Electrical Eng. & Systems 2021-04-07 Li Xiao , Yinhao Li , Luxi Qv , Xinxia Tian , Yijie Peng , S. Kevin Zhou

The use of complex machine learning models can make systems opaque to users. Machine learning research proposes the use of post-hoc explanations. However, it is unclear if they give users insights into otherwise uninterpretable models. One…

Human-Computer Interaction · Computer Science 2019-05-09 Martin Schuessler , Philipp Weiß

Statistical shape modeling (SSM) has recently taken advantage of advances in deep learning to alleviate the need for a time-consuming and expert-driven workflow of anatomy segmentation, shape registration, and the optimization of…

Computer Vision and Pattern Recognition · Computer Science 2020-07-14 Jadie Adams , Riddhish Bhalodia , Shireen Elhabian

Supervised deep learning for semantic segmentation has achieved excellent results in accurately identifying anatomical and pathological structures in medical images. However, it often requires large annotated training datasets, which limits…

Computer Vision and Pattern Recognition · Computer Science 2026-03-11 Luca Ciampi , Gabriele Lagani , Giuseppe Amato , Fabrizio Falchi

Voxel-based analysis methods localize brain structural differences by performing voxel-wise statistical comparisons on two groups of images aligned to a common space. This procedure requires highly accurate registration as well as a…

Modern longitudinal studies collect multiple outcomes as the primary endpoints to understand the complex dynamics of the diseases. Oftentimes, especially in clinical trials, the joint variations among the multidimensional responses play a…

Methodology · Statistics 2024-01-17 Salil Koner , Sheng Luo

The lack of large labeled medical imaging datasets, along with significant inter-individual variability compared to clinically established disease classes, poses significant challenges in exploiting medical imaging information in a…

Computer Vision and Pattern Recognition · Computer Science 2022-09-27 Matteo Ferrante , Tommaso Boccato , Simeon Spasov , Andrea Duggento , Nicola Toschi

Statistical samples, in order to be representative, have to be drawn from a population in a random and unbiased way. Nevertheless, it is common practice in the field of model-based diagnosis to make estimations from (biased) best-first…

Artificial Intelligence · Computer Science 2022-08-05 Patrick Rodler , Fatima Elichanova

Traditional supervised medical image segmentation models require large amounts of labeled data for training; however, obtaining such large-scale labeled datasets in the real world is extremely challenging. Recent semi-supervised…

Computer Vision and Pattern Recognition · Computer Science 2025-05-26 Yunyao Lu , Yihang Wu , Reem Kateb , Ahmad Chaddad

The increasing availability of large collections of electronic health record (EHR) data and unprecedented technical advances in deep learning (DL) have sparked a surge of research interest in developing DL based clinical decision support…

Machine Learning · Computer Science 2021-12-07 Di Jin , Elena Sergeeva , Wei-Hung Weng , Geeticka Chauhan , Peter Szolovits

Semantic segmentation is a crucial task in biomedical image processing, which recent breakthroughs in deep learning have allowed to improve. However, deep learning methods in general are not yet widely used in practice since they require…

Computer Vision and Pattern Recognition · Computer Science 2019-07-12 Melanie Lubrano di Scandalea , Christian S. Perone , Mathieu Boudreau , Julien Cohen-Adad

Machine learning and deep learning have been used extensively to classify physical surfaces through images and time-series contact data. However, these methods rely on human expertise and entail the time-consuming processes of data and…

Machine Learning · Computer Science 2023-08-10 Behnam Khojasteh , Friedrich Solowjow , Sebastian Trimpe , Katherine J. Kuchenbecker

Accurate and interpretable survival analysis remains a core challenge in oncology. With growing multimodal data and the clinical need for transparent models to support validation and trust, this challenge increases in complexity. We propose…

Artificial Intelligence · Computer Science 2025-09-29 Mafalda Malafaia , Peter A. N. Bosman , Coen Rasch , Tanja Alderliesten

Although machine learning (ML) models of AI achieve high performances in medicine, they are not free of errors. Empowering clinicians to identify incorrect model recommendations is crucial for engendering trust in medical AI. Explainable AI…

Artificial Intelligence · Computer Science 2022-12-20 Isil Guzey , Ozlem Ucar , Nukhet Aladag Ciftdemir , Betul Acunas

Cell counting in biomedical imaging is pivotal for various clinical applications, yet the interpretability of deep learning models in this domain remains a significant challenge. We propose a novel prototype-based method for interpretable…

Computer Vision and Pattern Recognition · Computer Science 2025-11-26 Abdurahman Ali Mohammed , Wallapak Tavanapong , Catherine Fonder , Donald S. Sakaguchi

The application of deep learning models in medical diagnosis has showcased considerable efficacy in recent years. Nevertheless, a notable limitation involves the inherent lack of explainability during decision-making processes. This study…

Image and Video Processing · Electrical Eng. & Systems 2024-05-01 Konstantinos Pasvantis , Eftychios Protopapadakis

Since the behavior of a neural network model is adversely affected by a lack of diversity in training data, we present a method that identifies and explains such deficiencies. When a dataset is labeled, we note that annotations alone are…

Computer Vision and Pattern Recognition · Computer Science 2020-12-17 Dhasarathy Parthasarathy , Anton Johansson

End-to-end deep learning models fed with multi-band galaxy images are powerful data-driven tools used to estimate galaxy physical properties in the absence of spectroscopy. However, due to a lack of interpretability and the associational…

Instrumentation and Methods for Astrophysics · Physics 2025-11-26 Wei Zhang , Qiufan Lin , Yuan-Sen Ting , Shupei Chen , Hengxin Ruan , Song Li , Yifan Wang

Deep learning models in medical imaging often fail when deployed in new clinical environments due to distribution shifts in demographics, scanner hardware, or acquisition protocols. A central challenge is underspecification, where models…

Computer Vision and Pattern Recognition · Computer Science 2026-05-12 Moritz Stammel , Fabio De Sousa Ribeiro , Raghav Mehta , Mélanie Roschewitz , Ben Glocker

The recent success of generative adversarial networks and variational learning suggests training a classifier network may work well in addressing the classical two-sample problem. Network-based tests have the computational advantage that…

Machine Learning · Statistics 2022-06-01 Xiuyuan Cheng , Alexander Cloninger
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