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Medical multiple-choice question answering (MCQA) is particularly difficult. Questions may describe patient symptoms and ask for the correct diagnosis, which requires domain knowledge and complex reasoning. Standard language modeling…

Computation and Language · Computer Science 2023-03-14 Damien Sileo , Kanimozhi Uma , Marie-Francine Moens

Large language models (LLMs) are increasingly adopted in clinical decision support, yet aligning them with the multifaceted reasoning pathways of real-world medicine remains a major challenge. Using more than 8,000 infertility treatment…

Machine Learning · Computer Science 2025-11-25 Dou Liu , Ying Long , Sophia Zuoqiu , Kaipeng Xie , Runze Yang , Di Liu , Kang Li , Yiting Lin , Hanyi Liu , Rong Yin , Tian Tang

In the ongoing wave of impact driven by large language models (LLMs) like ChatGPT, the adaptation of LLMs to medical domain has emerged as a crucial research frontier. Since mainstream LLMs tend to be designed for general-purpose…

Computation and Language · Computer Science 2023-12-04 Issey Sukeda , Masahiro Suzuki , Hiroki Sakaji , Satoshi Kodera

Despite the growing clinical adoption of large language models (LLMs), current approaches heavily rely on single model architectures. To overcome risks of obsolescence and rigid dependence on single model systems, we present a novel…

Artificial Intelligence · Computer Science 2025-06-24 Amit Kumthekar , Zion Tilley , Henry Duong , Bhargav Patel , Michael Magnoli , Ahmed Omar , Ahmed Nasser , Chaitanya Gharpure , Yevgen Reztzov

Large-scale language models (LLMs) like ChatGPT have demonstrated impressive abilities in generating responses based on human instructions. However, their use in the medical field can be challenging due to their lack of specific, in-depth…

Computation and Language · Computer Science 2025-02-25 Yubo Wang , Xueguang Ma , Wenhu Chen

Large Language Models (LLMs) have great potential in the field of health care, yet they face great challenges in adapting to rapidly evolving medical knowledge. This can lead to outdated or contradictory treatment suggestions. This study…

Computation and Language · Computer Science 2025-09-09 Weiyi Wu , Xinwen Xu , Chongyang Gao , Xingjian Diao , Siting Li , Lucas A. Salas , Jiang Gui

While LLM-based TTS models exhibit zero-shot emotion and speaker cloning, their cloning fidelity and pronunciation clarity degrade on unseen domains. Fine-tuning is essential for adaptation, yet uniform approaches overlook specific…

Audio and Speech Processing · Electrical Eng. & Systems 2026-03-09 Tianrui Wang , Meng Ge , Cheng Gong , Chunyu Qiang , Haoyu Wang , Zikang Huang , Yu Jiang , Ye Ni , Yuheng Lu , Xiaobao Wang , Engsiong Chng , Xie Chen , Longbiao Wang , Jianwu Dang

Hallucinated outputs from large language models (LLMs) pose risks in the medical domain, especially for lay audiences making health-related decisions. Existing automatic factual consistency evaluation methods, such as entailment- and…

Computation and Language · Computer Science 2026-03-20 Zhiwen You , Yue Guo

Reasoning Large Language Models (LLMs) with enhanced accuracy and explainability are increasingly being adopted in the medical domain, as the life-critical nature of clinical decision-making demands reliable support. Despite these…

Computation and Language · Computer Science 2025-11-12 Sung-Min Lee , Siyoon Lee , Juyeon Kim , Kyoungmin Roh

Clinical decision-making depends on expert reasoning, which is guided by standardized, evidence-based guidelines. However, translating these guidelines into automated clinical decision support systems risks inaccuracy and importantly, loss…

Interpretation is critical for disease diagnosis, but existing models struggle to balance predictive accuracy with human-understandable rationales. While large language models (LLMs) offer strong reasoning abilities, their clinical use is…

Computation and Language · Computer Science 2025-07-15 Shuai Niu , Jing Ma , Hongzhan Lin , Liang Bai , Zhihua Wang , Yida Xu , Yunya Song , Xian Yang

Community-based Question Answering (CQA) sites play an important role in addressing health information needs. However, a significant number of posted questions remain unanswered. Automatically answering the posted questions can provide a…

Machine Learning · Statistics 2016-07-05 Papis Wongchaisuwat , Diego Klabjan , Siddhartha R. Jonnalagadda

The increasing use of tools and solutions based on Large Language Models (LLMs) for various tasks in the medical domain has become a prominent trend. Their use in this highly critical and sensitive domain has thus raised important questions…

Computation and Language · Computer Science 2024-01-09 Jean-Baptiste Excoffier , Tom Roehr , Alexei Figueroa , Jens-Michalis Papaioannou , Keno Bressem , Matthieu Ortala

Large language models (LLMs) have demonstrated impressive capabilities in natural language understanding and generation, but the quality bar for medical and clinical applications is high. Today, attempts to assess models' clinical knowledge…

Large language models (LLMs) are rapidly transitioning into medical clinical use, yet their reliability under realistic, multi-turn interactions remains poorly understood. Existing evaluation frameworks typically assess single-turn question…

Computation and Language · Computer Science 2025-10-15 Blazej Manczak , Eric Lin , Francisco Eiras , James O' Neill , Vaikkunth Mugunthan

The aim of this paper is to evaluate whether large language models trained on multi-choice question data can be used to discriminate between medical subjects. This is an important and challenging task for automatic question answering. To…

Computation and Language · Computer Science 2024-03-22 Víctor Ponce-López

Large language models (LLMs) holds significant promise in achieving general medication recommendation systems owing to their comprehensive interpretation of clinical notes and flexibility to medication encoding. We evaluated both…

Information Retrieval · Computer Science 2025-08-05 Zihao Zhao , Chenxiao Fan , Junlong Liu , Zheng Wang , Xiangnan He , Chongming Gao , Juan Li , Fuli Feng

Large Language Model (LLM)-based systems present new opportunities for autonomous health monitoring in sensor-rich industrial environments. This study explores the potential of LLMs to detect and classify faults directly from sensor data,…

Artificial Intelligence · Computer Science 2025-09-30 Xian Yeow Lee , Lasitha Vidyaratne , Ahmed Farahat , Chetan Gupta

Large Language Models (LLMs) have recently demonstrated strong potential for cybersecurity question answering (QA), supporting decision-making in real-time threat detection and response workflows. However, their substantial computational…

Cryptography and Security · Computer Science 2025-09-18 Onat Gungor , Roshan Sood , Harold Wang , Tajana Rosing

Large language models (LLMs) have recently been applied to dialog systems. Despite making progress, LLMs are prone to errors in knowledge-intensive scenarios. Recently, approaches based on retrieval augmented generation (RAG) and agent have…

Computation and Language · Computer Science 2025-07-01 Yucheng Cai , Yuxuan Wu , Yi Huang , Junlan Feng , Zhijian Ou