Related papers: Knowing When to Abstain: Medical LLMs Under Clinic…

For Large Language Models (LLMs) to be reliably deployed in both everyday and high-stakes domains, knowing when not to answer is equally critical as answering correctly. Real-world user queries, which can be underspecified, ill-posed, or…

Abstention, the refusal of large language models (LLMs) to provide an answer, is increasingly recognized for its potential to mitigate hallucinations and enhance safety in LLM systems. In this survey, we introduce a framework to examine…

Abstention Ability (AA) is a critical aspect of Large Language Model (LLM) reliability, referring to an LLM's capability to withhold responses when uncertain or lacking a definitive answer, without compromising performance. Although…

This study investigates uncertainty quantification in large language models (LLMs) for medical applications, emphasizing both technical innovations and philosophical implications. As LLMs become integral to clinical decision-making,…

Large Language Models (LLMs) often exhibit knowledge disparities across languages. Encouraging LLMs to \textit{abstain} when faced with knowledge gaps is a promising strategy to reduce hallucinations in multilingual settings. Current…

A major barrier towards the practical deployment of large language models (LLMs) is their lack of reliability. Three situations where this is particularly apparent are correctness, hallucinations when given unanswerable questions, and…

Large Language Models (LLMs) can produce surprisingly sophisticated estimates of their own uncertainty. However, it remains unclear to what extent this expressed confidence is tied to the reasoning, knowledge, or decision making of the…

Effective abstention (EA), recognizing evidence insufficiency and refraining from answering, is critical for reliable multimodal systems. Yet existing evaluation paradigms for vision-language models (VLMs) and multi-agent systems (MAS)…

Large language models are increasingly used to answer and verify scientific claims, yet existing evaluations typically assume that a model must always produce a definitive answer. In scientific settings, however, unsupported or uncertain…

Medical large language model (LLM) evaluations rely on simplified, exam-style benchmarks that rarely reflect the ambiguity of real-world medical inquiries. We introduce the CLinical Evaluation of Ambiguity and Reliability (CLEAR) framework,…

Large language models often generate confident but incorrect answers rather than abstaining when uncertain. This problem is particularly acute for small language models (SLMs), where computational constraints and autonomous operation…

In clinical practice, physicians refrain from making decisions when patient information is insufficient. This behavior, known as abstention, is a critical safety mechanism preventing potentially harmful misdiagnoses. Recent investigations…

Although large language models (LLMs) are highly interactive and extendable, current approaches to ensure reliability in deployments remain mostly limited to rejecting outputs with high uncertainty in order to avoid misinformation. This…

Reliability of LLMs is questionable even as they get better at more tasks. A wider adoption of LLMs is contingent on whether they are usably factual. And if they are not, on whether they can properly calibrate their confidence in their…

Large language models (LLMs) have the potential to transform medicine, but real-world clinical scenarios contain extraneous information that can hinder performance. The rise of assistive technologies like ambient dictation, which…

Large Language Models (LLMs) demonstrate exceptional performance across diverse tasks by leveraging pre-trained (i.e., parametric) and external (i.e., contextual) knowledge. While substantial efforts have been made to enhance the…

Biomedical retrieval-augmented large language models (LLMs) often face evidence that is incomplete, misleading, or internally contradictory, yet evaluation usually emphasizes answer accuracy under helpful context rather than reliability…

LLM cascades deploy small LLMs to answer most queries, limiting the use of large and expensive LLMs to difficult queries. This approach can significantly reduce costs without impacting performance. However, risk-sensitive domains such as…

This study addresses the critical issue of reliability for AI-assisted medical diagnosis. We focus on the selection prediction approach that allows the diagnosis system to abstain from providing the decision if it is not confident in the…

Safety alignment in large language models (LLMs) is primarily evaluated under open-ended generation, where models can mitigate risk by refusing to respond. In contrast, many real-world applications place LLMs in structured decision-making…