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Adverse drug events (ADEs) are an important aspect of drug safety. Various texts such as biomedical literature, drug reviews, and user posts on social media and medical forums contain a wealth of information about ADEs. Recent studies have…

Computation and Language · Computer Science 2024-05-21 Shaoxiong Ji , Ya Gao , Pekka Marttinen

Predicting missing facts in a knowledge graph (KG) is a crucial task in knowledge base construction and reasoning, and it has been the subject of much research in recent works using KG embeddings. While existing KG embedding approaches…

Computation and Language · Computer Science 2020-10-09 Xuelu Chen , Muhao Chen , Changjun Fan , Ankith Uppunda , Yizhou Sun , Carlo Zaniolo

Biomedical discovery often requires connecting broad biomedical knowledge with specific experimental or clinical data. Background knowledge suggests relevant mechanisms but is usually too general to map directly onto dataset variables,…

Artificial Intelligence · Computer Science 2026-05-27 Qingyuan Zeng , Ziyang Chen , Pengxiang Cai , Zixin Guan , Anglin Liu , Lang Qin , Xinyao Lai , Jintai Chen

Knowledge graphs (KGs) are powerful tools for representing and reasoning over structured information. Their main components include schema, identity, and context. While schema and identity matching are well-established in ontology and…

Computation and Language · Computer Science 2025-08-01 Victor Eiti Yamamoto , Hideaki Takeda

The autonomous driving (AD) industry is exploring the use of knowledge graphs (KGs) to manage the vast amount of heterogeneous data generated from vehicular sensors. The various types of equipped sensors include video, LIDAR and RADAR.…

Artificial Intelligence · Computer Science 2020-03-03 Ruwan Wickramarachchi , Cory Henson , Amit Sheth

Thanks to the increasing availability of drug-drug interactions (DDI) datasets and large biomedical knowledge graphs (KGs), accurate detection of adverse DDI using machine learning models becomes possible. However, it remains largely an…

Machine Learning · Computer Science 2021-05-10 Yue Yu , Kexin Huang , Chao Zhang , Lucas M. Glass , Jimeng Sun , Cao Xiao

Question Answer (QA) systems for biomedical experiments facilitate cross-disciplinary communication, and serve as a foundation for downstream tasks, e.g., laboratory automation. High Information Density (HID) and Multi-Step Reasoning (MSR)…

Artificial Intelligence · Computer Science 2026-01-09 Haofei Hou , Shunyi Zhao , Fanxu Meng , Kairui Yang , Lecheng Ruan , Qining Wang

Biomedical knowledge graphs underwrite drug repurposing and clinical decision support, yet the upstream ontologies they depend on update on independent cycles that add millions of edges and deprecate hundreds of thousands more between…

Artificial Intelligence · Computer Science 2026-05-12 Yousef A. Radwan , Yao Li , Qing Qing , Ziqi Xu , Xingtong Yu , Jiaxing Huang , Renqiang Luo , Xikun Zhang

Knowledge graphs (KGs) represent connections and relationships between real-world entities. We propose a link prediction framework for KGs named Enrichment-Driven GrAph Reasoner (EDGAR), which infers new edges by mining entity-local rules.…

Information Theory · Computer Science 2024-11-14 Olawumi Olasunkanmi , Evan Morris , Yaphet Kebede , Harlin Lee , Stanley Ahalt , Alexander Tropsha , Chris Bizon

Knowledge Graphs (KG) constitute a flexible representation of complex relationships between entities particularly useful for biomedical data. These KG, however, are very sparse with many missing edges (facts) and the visualisation of the…

Artificial Intelligence · Computer Science 2016-12-08 Armando Vieira

Even for a conservative estimate, 80% of enterprise data reside in unstructured files, stored in data lakes that accommodate heterogeneous formats. Classical search engines can no longer meet information seeking needs, especially when the…

Computation and Language · Computer Science 2024-06-06 Qiang Sun , Yuanyi Luo , Wenxiao Zhang , Sirui Li , Jichunyang Li , Kai Niu , Xiangrui Kong , Wei Liu

Predicting medications is a crucial task in many intelligent healthcare systems. It can assist doctors in making informed medication decisions for patients according to electronic medical records (EMRs). However, medication prediction is a…

Artificial Intelligence · Computer Science 2022-05-02 Yang An , Bo Jin , Xiaopeng Wei

Knowledge Graph Embedding (KGE) models are used to learn continuous representations of entities and relations. A key task in the literature is predicting missing links between entities. However, Knowledge Graphs are not just sets of links…

Artificial Intelligence · Computer Science 2023-08-28 Thiviyan Thanapalasingam , Emile van Krieken , Peter Bloem , Paul Groth

Knowledge graphs (KGs) are widely used for representing and organizing structured knowledge in diverse domains. However, the creation and upkeep of KGs pose substantial challenges. Developing a KG demands extensive expertise in data…

Information Retrieval · Computer Science 2023-09-19 Samira Babalou , Sheeba Samuel , Birgitta König-Ries

Drug Side-Effects (DSEs) have a high impact on public health, care system costs, and drug discovery processes. Predicting the probability of side-effects, before their occurrence, is fundamental to reduce this impact, in particular on drug…

Quantitative Methods · Quantitative Biology 2022-02-17 Pietro Bongini , Franco Scarselli , Monica Bianchini , Giovanna Maria Dimitri , Niccolò Pancino , Pietro Liò

Pursuing artificial intelligence for biomedical science, a.k.a. AI Scientist, draws increasing attention, where one common approach is to build a copilot agent driven by Large Language Models (LLMs). However, to evaluate such systems,…

Computation and Language · Computer Science 2024-07-02 Xinna Lin , Siqi Ma , Junjie Shan , Xiaojing Zhang , Shell Xu Hu , Tiannan Guo , Stan Z. Li , Kaicheng Yu

Recent advances in deep research systems enable large language models to retrieve, synthesize, and reason over large-scale external knowledge. In medicine, developing clinical guidelines critically depends on such deep evidence integration.…

Knowledge graph (KG) embedding methods which map entities and relations to unique embeddings in the KG have shown promising results on many reasoning tasks. However, the same embedding dimension for both dense entities and sparse entities…

Computation and Language · Computer Science 2022-05-06 Linlin Chao , Xiexiong Lin , Taifeng Wang , Wei Chu

Knowledge graphs (KGs) offer a rich representation for relational knowledge, but their irregular structure makes retrieval challenging: ego-graph expansion grows rapidly, and dense embedding methods struggle with multi-hop compositional…

Machine Learning · Computer Science 2026-05-25 Hamed Shirzad , Frederik Wenkel , Dominique Beaini , Danica J. Sutherland , Emmanuel Noutahi

Heterogeneous molecular entities and their interactions, commonly depicted as a network, are crucial for advancing our systems-level understanding of biology. With recent advancements in high-throughput data generation and a significant…

Quantitative Methods · Quantitative Biology 2026-03-18 Kishan KC , Rui Li , Paribesh Regmi , Anne R. Haake
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