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The process of matching patients with suitable clinical trials is essential for advancing medical research and providing optimal care. However, current approaches face challenges such as data standardization, ethical considerations, and a…

Computation and Language · Computer Science 2023-08-08 Jiayi Yuan , Ruixiang Tang , Xiaoqian Jiang , Xia Hu

Creating secure and resilient applications with large language models (LLM) requires anticipating, adjusting to, and countering unforeseen threats. Red-teaming has emerged as a critical technique for identifying vulnerabilities in…

While incorporating LLMs into systems offers significant benefits in critical application areas such as healthcare, new security challenges emerge due to the potential cyber kill chain cycles that combine adversarial model, prompt injection…

Cryptography and Security · Computer Science 2026-03-05 Neha Nagaraja , Hayretdin Bahsi

Recent advances in Retrieval-Augmented Generation (RAG) have enabled large language models (LLMs) to ground outputs in clinical evidence. However, connecting LLMs with external databases introduces the risk of contextual leakage: a subtle…

Computation and Language · Computer Science 2026-03-17 Shaowei Guan , Yu Zhai , Hin Chi Kwok , Jiawei Du , Xinyu Feng , Jing Li , Harry Qin , Vivian Hui

Inspired by the rapid development of Large Language Models (LLMs), LLM agents have evolved to perform complex tasks. LLM agents are now extensively applied across various domains, handling vast amounts of data to interact with humans and…

Cryptography and Security · Computer Science 2025-11-04 Feng He , Tianqing Zhu , Dayong Ye , Bo Liu , Wanlei Zhou , Philip S. Yu

Large language models (LLMs) demonstrate remarkable medical expertise, but data privacy concerns impede their direct use in healthcare environments. Although offering improved data privacy protection, domain-specific small language models…

Computation and Language · Computer Science 2024-05-17 Xinlu Zhang , Shiyang Li , Xianjun Yang , Chenxin Tian , Yao Qin , Linda Ruth Petzold

The application of large language models (LLMs) in healthcare has gained significant attention due to their ability to process complex medical data and provide insights for clinical decision-making. These models have demonstrated…

Computer Vision and Pattern Recognition · Computer Science 2024-09-26 Amna Khalid , Ayma Khalid , Umar Khalid

The rapid advancement of Large Language Models (LLMs) has created new opportunities for Automated Penetration Testing (AutoPT), spawning numerous frameworks aimed at achieving end-to-end autonomous attacks. However, despite the…

The widespread deployment of LLM-based agents is likely to introduce a critical privacy threat: malicious agents that proactively engage others in multi-turn interactions to extract sensitive information. However, the evolving nature of…

Cryptography and Security · Computer Science 2026-05-11 Yanzhe Zhang , Diyi Yang

With the rapid development of technology and the acceleration of digitalisation, the frequency and complexity of cyber security threats are increasing. Traditional cybersecurity approaches, often based on static rules and predefined…

Cryptography and Security · Computer Science 2025-04-29 Shuang Tian , Tao Zhang , Jiqiang Liu , Jiacheng Wang , Xuangou Wu , Xiaoqiang Zhu , Ruichen Zhang , Weiting Zhang , Zhenhui Yuan , Shiwen Mao , Dong In Kim

Large Language Models (LLMs) are transforming mental health care by enhancing accessibility, personalization, and efficiency in therapeutic interventions. These AI-driven tools empower mental health professionals with real-time support,…

Computers and Society · Computer Science 2025-01-22 Hari Mohan Pandey

The rise of electronic health records (EHRs) has unlocked new opportunities for medical research, but privacy regulations and data heterogeneity remain key barriers to large-scale machine learning. Federated learning (FL) enables…

Machine Learning · Computer Science 2025-05-27 Natallia Kokash , Lei Wang , Thomas H. Gillespie , Adam Belloum , Paola Grosso , Sara Quinney , Lang Li , Bernard de Bono

Modern life has witnessed the explosion of mobile devices. However, besides the valuable features that bring convenience to end users, security and privacy risks still threaten users of mobile apps. The increasing sophistication of these…

Cryptography and Security · Computer Science 2025-12-02 Tran Thanh Lam Nguyen , Barbara Carminati , Elena Ferrari

The emergence of large language models (LLMs), and their increased use in user-facing systems, has led to substantial privacy concerns. To date, research on these privacy concerns has been model-centered: exploring how LLMs lead to privacy…

Human-Computer Interaction · Computer Science 2024-02-06 Tianshi Li , Sauvik Das , Hao-Ping Lee , Dakuo Wang , Bingsheng Yao , Zhiping Zhang

Large language model (LLM) services have been rapidly integrated into people's daily lives as chatbots and agentic systems. They are nourished by collecting rich streams of data, raising privacy concerns around excessive collection of…

Cryptography and Security · Computer Science 2025-12-01 Zhen Tao , Shidong Pan , Zhenchang Xing , Emily Black , Talia Gillis , Chunyang Chen

The Model Context Protocol (MCP) has emerged as the de facto standard for connecting Large Language Models (LLMs) to external data and tools, effectively functioning as the "USB-C for Agentic AI." While this decoupling of context and…

Cryptography and Security · Computer Science 2025-12-16 Shiva Gaire , Srijan Gyawali , Saroj Mishra , Suman Niroula , Dilip Thakur , Umesh Yadav

Large Language Models (LLMs) have achieved remarkable progress, but their deployment has exposed critical vulnerabilities, particularly to jailbreak attacks that circumvent safety alignments. Guardrails--external defense mechanisms that…

Cryptography and Security · Computer Science 2025-10-17 Xunguang Wang , Zhenlan Ji , Wenxuan Wang , Zongjie Li , Daoyuan Wu , Shuai Wang

The idea of applying machine learning(ML) to solve problems in security domains is almost 3 decades old. As information and communications grow more ubiquitous and more data become available, many security risks arise as well as appetite to…

Cryptography and Security · Computer Science 2016-11-11 Heju Jiang , Jasvir Nagra , Parvez Ahammad

Large Language Models (LLMs), now a foundation in advancing natural language processing, power applications such as text generation, machine translation, and conversational systems. Despite their transformative potential, these models…

Cryptography and Security · Computer Science 2025-08-05 Kang Chen , Xiuze Zhou , Yuanguo Lin , Jinhe Su , Yuanhui Yu , Li Shen , Fan Lin

The interactive nature of Large Language Models (LLMs), which closely track user data and context, has prompted users to share personal and private information in unprecedented ways. Even when users opt out of allowing their data to be used…

Cryptography and Security · Computer Science 2025-08-26 GodsGift Uzor , Hasan Al-Qudah , Ynes Ineza , Abdul Serwadda