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Reliable deployment of language models requires two capabilities that appear distinct but share a common geometric foundation: predicting whether a model will accept targeted behavioral control, and detecting when its internal structure…

Machine Learning · Computer Science 2026-04-30 Prashant C. Raju

Genome engineering has achieved remarkable sequence-level precision, yet predicting the transcriptomic state that a cell will occupy after perturbation remains an open problem. Single-cell CRISPR screens measure how far cells move from…

Quantitative Methods · Quantitative Biology 2026-05-13 Prashant C. Raju

Quantifying similarity between neural representations -- e.g. hidden layer activation vectors -- is a perennial problem in deep learning and neuroscience research. Existing methods compare deterministic responses (e.g. artificial networks…

Machine Learning · Computer Science 2023-02-07 Lyndon R. Duong , Jingyang Zhou , Josue Nassar , Jules Berman , Jeroen Olieslagers , Alex H. Williams

Previous work has established that neural network-based node embeddings return different outcomes when trained with identical parameters on the same dataset, just from using different training seeds. Yet, it has not been thoroughly analyzed…

Machine Learning · Computer Science 2026-04-10 Tobias Schumacher , Simon Reichelt , Markus Strohmaier

Artificial and biological agents cannon learn given completely random and unstructured data. The structure of data is encoded in the metric relationships between data points. In the context of neural networks, neuronal activity within a…

Machine Learning · Computer Science 2022-11-03 Kosio Beshkov , Jonas Verhellen , Mikkel Elle Lepperød

Understanding how neural representations respond to geometric transformations is essential for evaluating whether learned features preserve meaningful spatial structure. Existing approaches primarily assess robustness primarily by comparing…

Machine Learning · Computer Science 2026-05-12 Huahua Lin , Katayoun Farrahi , Xiaohao Cai

Stochastic Gradient Descent (SGD) stands as a cornerstone optimization algorithm with proven real-world empirical successes but relatively limited theoretical understanding. Recent research has illuminated a key factor contributing to its…

Machine Learning · Computer Science 2024-01-24 Gregory Dexter , Borja Ocejo , Sathiya Keerthi , Aman Gupta , Ayan Acharya , Rajiv Khanna

We study the problem of linear feature selection when features are highly correlated. Such settings pose two fundamental challenges. First, how should model similarity be defined? Simply counting features in common can be misleading: two…

Methodology · Statistics 2026-03-24 Xiaozhu Zhang , Jacob Bien , Armeen Taeb

Deep networks learn internal representations whose geometry--how features bend, rotate, and evolve--affects both generalization and robustness. Existing similarity measures such as CKA or SVCCA capture pointwise overlap between activation…

Machine Learning · Computer Science 2026-01-30 Vasileios Sevetlidis , George Pavlidis

Similarity measures are widely used to interpret the representational geometries used by neural networks to solve tasks. Yet, because existing methods compare the extrinsic geometry of representations in state space, rather than their…

Machine Learning · Computer Science 2026-04-03 N Alex Cayco-Gajic , Arthur Pellegrino

We propose a method for self-supervised image representation learning under the guidance of 3D geometric consistency. Our intuition is that 3D geometric consistency priors such as smooth regions and surface discontinuities may imply…

Computer Vision and Pattern Recognition · Computer Science 2022-03-30 Nenglun Chen , Lei Chu , Hao Pan , Yan Lu , Wenping Wang

The capacity to precisely edit genomes has outpaced our ability to predict the consequences. A cell can be genetically perfect and therapeutically useless: edited exactly as intended, yet unstable, drifting toward unintended fates, or…

Quantitative Methods · Quantitative Biology 2026-04-28 Prashant C. Raju

Foundation models for biology and physics optimize predictive accuracy, but their internal representations systematically fail to preserve the continuous geometry of the systems they model. We identify the root cause: the Geometric…

Machine Learning · Computer Science 2026-04-07 Prashant C. Raju

Representational similarity analysis (RSA) tests models of brain computation by investigating how neural activity patterns reflect experimental conditions. Instead of predicting activity patterns directly, the models predict the geometry of…

How can we tell whether two neural networks utilize the same internal processes for a particular computation? This question is pertinent for multiple subfields of neuroscience and machine learning, including neuroAI, mechanistic…

Neurons and Cognition · Quantitative Biology 2023-10-31 Mitchell Ostrow , Adam Eisen , Leo Kozachkov , Ila Fiete

To preserve previously learned representations, continual learning systems must strike a balance between plasticity, the ability to acquire new knowledge, and stability. This stability-plasticity dilemma affects how representations can be…

Machine Learning · Computer Science 2026-05-01 Kathrin Korte , Joachim Winter Pedersen , Eleni Nisioti , Sebastian Risi

Diffusion geometry is a manifold learning framework that uses random walks defined by Markov transition matrices to characterize the geometry of a dataset at multiple scales. We use diffusion geometry for neural representations,…

Machine Learning · Computer Science 2026-05-18 Atharva Khandait , Jan E. Gerken

Language models exhibit strong robustness to paraphrasing, suggesting that semantic information may be encoded through stable internal representations, yet the structure and origin of such invariance remain unclear. We propose a local…

Machine Learning · Computer Science 2026-05-08 Agnibh Dasgupta , Abdullah Tanvir , Xin Zhong

To overcome the restriction of identical distribution assumption, invariant representation learning for unsupervised domain adaptation (UDA) has made significant advances in computer vision and pattern recognition communities. In UDA…

Computer Vision and Pattern Recognition · Computer Science 2024-07-16 You-Wei Luo , Chuan-Xian Ren , Xiao-Lin Xu , Qingshan Liu

The extent to which different biological and artificial neural systems rely on equivalent internal representations to support similar tasks remains a central question in neuroscience and machine learning. Prior work typically compares…

Computer Vision and Pattern Recognition · Computer Science 2026-02-24 Jialin Wu , Shreya Saha , Yiqing Bo , Meenakshi Khosla
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