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LLM-based agents have emerged as transformative tools capable of executing complex tasks through iterative planning and action, achieving significant advancements in understanding and addressing user needs. Yet, their effectiveness remains…

Human-Computer Interaction · Computer Science 2025-08-26 Mithat Can Ozgun , Jiahuan Pei , Koen Hindriks , Lucia Donatelli , Qingzhi Liu , Junxiao Wang

Agentic Reinforcement Learning (ARL) trains large language models to interleave reasoning with external tool execution to solve complex tasks. Most existing ARL methods train a single set of parameters to support both reasoning and tool-use…

Artificial Intelligence · Computer Science 2026-05-29 Yu Li , Mingyang Yi , Xiuyu Li , Ju Fan , Fuxin Jiang , Binbin Chen , Peng Li , Jie Song , Tieying Zhang

Many benchmarks for automated causal inference evaluate a system's performance based on a single numerical output, such as an Average Treatment Effect (ATE). This approach conflates two distinct steps in causal analysis: identification -…

Artificial Intelligence · Computer Science 2026-05-15 Ayush Sawarni , Jiyuan Tan , Vasilis Syrgkanis

Evaluating large language models (LLM) in clinical scenarios is crucial to assessing their potential clinical utility. Existing benchmarks rely heavily on static question-answering, which does not accurately depict the complex, sequential…

Human-Computer Interaction · Computer Science 2025-05-27 Samuel Schmidgall , Rojin Ziaei , Carl Harris , Eduardo Reis , Jeffrey Jopling , Michael Moor

Large Language Models (LLMs) have demonstrated remarkable capabilities in natural language understanding and generation. However, single-model responses often exhibit inconsistencies, hallucinations, and varying quality across different…

Computation and Language · Computer Science 2025-12-25 Omer Jauhar Khan

The meaningful use of electronic health records (EHR) continues to progress in the digital era with clinical decision support systems augmented by artificial intelligence. A priority in improving provider experience is to overcome…

Computation and Language · Computer Science 2023-01-30 Yanjun Gao , Dmitriy Dligach , Timothy Miller , John Caskey , Brihat Sharma , Matthew M Churpek , Majid Afshar

Large language models (LLMs) are increasingly used in clinical settings, raising concerns about racial bias in both generated medical text and clinical reasoning. Existing studies have identified bias in medical LLMs, but many focus on…

Computers and Society · Computer Science 2026-04-21 Sihao Xing , Zaur Gouliev

We introduce PhysicianBench, a benchmark for evaluating LLM agents on physician tasks grounded in real clinical setting within electronic health record (EHR) environments. Existing medical agent benchmarks primarily focus on static…

Motivated by the challenge to improve the adversarial robustness, security, and trust of medical decision making intelligent agents, this study develops a full-link security enhancement framework, which describes "input risk perception -…

Cryptography and Security · Computer Science 2026-05-12 Saisai Hu

The ability of large language models (LLMs) to mimic human-like intelligence has led to a surge in LLM-based autonomous agents. Though recent LLMs seem capable of planning and reasoning given user instructions, their effectiveness in…

The recent shift toward the Health Level Seven Fast Healthcare Interoperability Resources (HL7 FHIR) standard opens a new frontier for clinical AI, demanding LLM agents to navigate complex, resource-based data models instead of conventional…

Computation and Language · Computer Science 2025-11-14 Gyubok Lee , Elea Bach , Eric Yang , Tom Pollard , Alistair Johnson , Edward Choi , Yugang jia , Jong Ha Lee

Understanding and reasoning on the large-scale scientific literature is a crucial touchstone for large language model (LLM) based agents. However, existing works are mainly restricted to tool-free tasks within single papers, largely due to…

Artificial Intelligence · Computer Science 2026-02-02 Daoyu Wang , Mingyue Cheng , Shuo Yu , Zirui Liu , Ze Guo , Xin Li , Qi Liu

Next-generation AI must manage vast personal data, diverse tools, and multi-step reasoning, yet most benchmarks remain context-free and single-turn. We present ASTRA-bench (Assistant Skills in Tool-use, Reasoning \& Action-planning), a…

Artificial Intelligence · Computer Science 2026-03-03 Zidi Xiu , David Q. Sun , Kevin Cheng , Maitrik Patel , Josh Date , Yizhe Zhang , Jiarui Lu , Omar Attia , Raviteja Vemulapalli , Oncel Tuzel , Meng Cao , Samy Bengio

Various human activities can be abstracted into a sequence of actions in natural text, i.e. cooking, repairing, manufacturing, etc. Such action sequences heavily depend on the executing order, while disorder in action sequences leads to…

Computation and Language · Computer Science 2023-06-08 Weizhi Wang , Hong Wang , Xifeng Yan

Recent advancements in Multi-Agent Systems (MAS) powered by Large Language Models (LLMs) have demonstrated tremendous potential in diverse task scenarios. Nonetheless, existing agentic systems typically rely on predefined agent-role design…

Multiagent Systems · Computer Science 2025-05-21 Zhipeng Hou , Junyi Tang , Yipeng Wang

Large Language Model (LLM)-based agents are increasingly deployed for complex, tool-based tasks where long-term memory is critical to driving actions. Existing benchmarks, however, primarily test a angent's ability to passively retrieve…

Computation and Language · Computer Science 2026-01-29 Yiting Shen , Kun Li , Wei Zhou , Songlin Hu

Clinical reasoning demands multi-step interactions -- gathering patient history, ordering tests, interpreting results, and making safe treatment decisions -- yet a unified training environment provides the breadth of clinical domains and…

Machine Learning · Computer Science 2026-05-06 Minbyul Jeong

Ensuring the safety of large language models (LLMs) is paramount, yet identifying potential vulnerabilities is challenging. While manual red teaming is effective, it is time-consuming, costly and lacks scalability. Automated red teaming…

Cryptography and Security · Computer Science 2024-12-24 Bojian Jiang , Yi Jing , Tianhao Shen , Tong Wu , Qing Yang , Deyi Xiong

Autonomous coding agents built on large language models (LLMs) can now solve many general software and machine learning tasks, but they remain ineffective on complex, domain-specific scientific problems. Medical imaging is a particularly…

Computer Vision and Pattern Recognition · Computer Science 2025-12-22 Roshan Kenia , Xiaoman Zhang , Pranav Rajpurkar

Modern clinical practice relies on evidence-based guidelines implemented as compact scoring systems composed of a small number of interpretable decision rules. While machine-learning models achieve strong performance, many fail to translate…

Machine Learning · Computer Science 2026-05-25 Silas Ruhrberg Estévez , Christopher Chiu , Mihaela van der Schaar