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The evaluation and improvement of medical large language models (LLMs) are critical for their real-world deployment, particularly in ensuring accuracy, safety, and ethical alignment. Existing frameworks inadequately dissect domain-specific…

Computation and Language · Computer Science 2025-03-11 Luyi Jiang , Jiayuan Chen , Lu Lu , Xinwei Peng , Lihao Liu , Junjun He , Jie Xu

Deep reasoning is fundamental for solving complex tasks, especially in vision-centric scenarios that demand sequential, multimodal understanding. However, existing benchmarks typically evaluate agents with fully synthetic, single-turn…

Clinical reasoning agents based on large language models (LLMs) aim to automate tasks such as intensive care unit (ICU) monitoring and patient state tracking from electronic health records (EHRs). Existing systems typically rely on manually…

Artificial Intelligence · Computer Science 2026-05-12 Timothy Ossowski , Xinchi Liu , Danyal Maqbool , Vaibhav Dhanuka , Sheng Zhang , Hoifung Poon , Majid Afshar , Tyler Bradshaw , Junjie Hu

Clinical reasoning in medicine is a hypothesis-driven process where physicians refine diagnoses from limited information through targeted history, physical examination, and diagnostic investigations. In contrast, current medical benchmarks…

Machine Learning · Computer Science 2025-10-14 Christopher Chiu , Silviu Pitis , Mihaela van der Schaar

Large Language Model (LLM)-based agents that plan, use tools and act has begun to shape healthcare and medicine. Reported studies demonstrate competence on various tasks ranging from EHR analysis and differential diagnosis to treatment…

Artificial Intelligence · Computer Science 2026-02-05 Shubham Vatsal , Harsh Dubey , Aditi Singh

This paper presents an innovative large language model (LLM) agent framework for enhancing diagnostic accuracy in simulated clinical environments using the AgentClinic benchmark. The proposed automatic correction enables doctor agents to…

Artificial Intelligence · Computer Science 2024-10-15 Abhishek Dutta , Yen-Che Hsiao

Large Language Models (LLMs) have shown impressive performance on existing medical question-answering benchmarks. This high performance makes it increasingly difficult to meaningfully evaluate and differentiate advanced methods. We present…

Computation and Language · Computer Science 2025-03-21 Xiangru Tang , Daniel Shao , Jiwoong Sohn , Jiapeng Chen , Jiayi Zhang , Jinyu Xiang , Fang Wu , Yilun Zhao , Chenglin Wu , Wenqi Shi , Arman Cohan , Mark Gerstein

The rise of large language models (LLMs) has shifted time series analysis from narrow analytics to general-purpose reasoning. Yet, existing benchmarks cover only a small set of health time series modalities and tasks, failing to reflect the…

Machine Learning · Computer Science 2026-03-17 Sirui Li , Shuhan Xiao , Mihir Joshi , Ahmed Metwally , Daniel McDuff , Wei Wang , Yuzhe Yang

The advancement of large language model (LLM) based agents has shifted AI evaluation from single-turn response assessment to multi-step task completion in interactive environments. We present an empirical study evaluating frontier AI models…

Artificial Intelligence · Computer Science 2026-01-15 Logan Ritchie , Sushant Mehta , Nick Heiner , Mason Yu , Edwin Chen

As AI agents proliferate across industries and applications, evaluating their performance based solely on infrastructural metrics such as latency, time-to-first-token, or token throughput is proving insufficient. These metrics fail to…

Artificial Intelligence · Computer Science 2025-11-12 Waseem AlShikh , Muayad Sayed Ali , Brian Kennedy , Dmytro Mozolevskyi

Many students in introductory programming courses fare poorly in the code writing tasks of the final summative assessment. Such tasks are designed to assess whether novices have developed the analytical skills to translate from the given…

Software Engineering · Computer Science 2024-04-04 Shruthi Ravikumar , Margaret Hamilton , Charles Thevathayan , Maria Spichkova , Kashif Ali , Gayan Wijesinghe

Creating high-quality clinical Chains-of-Thought (CoTs) is crucial for explainable medical Artificial Intelligence (AI) while constrained by data scarcity. Although Large Language Models (LLMs) can synthesize medical data, their clinical…

Artificial Intelligence · Computer Science 2025-10-21 Dou Liu , Ying Long , Sophia Zuoqiu , Di Liu , Kang Li , Yiting Lin , Hanyi Liu , Rong Yin , Tian Tang

Retrieval-Augmented Generation (RAG) mitigates key limitations of Large Language Models (LLMs)-such as factual errors, outdated knowledge, and hallucinations-by dynamically retrieving external information. Recent work extends this paradigm…

Computation and Language · Computer Science 2026-05-22 Jingru Lin , Chen Zhang , Stephen Y. Liu , Haizhou Li

Large Language Model (LLM)-powered Multi-agent systems (MAS) have achieved state-of-the-art results on various complex reasoning tasks. Recent works have proposed techniques to automate the design of MASes, eliminating the need for manual…

Artificial Intelligence · Computer Science 2026-05-20 Bohan Yao , Shiva Krishna Reddy Malay , Vikas Yadav

Recent large language models (LLMs) have demonstrated significant advancements, particularly in their ability to serve as agents thereby surpassing their traditional role as chatbots. These agents can leverage their planning and tool…

Machine Learning · Computer Science 2025-02-13 Yixing Jiang , Kameron C. Black , Gloria Geng , Danny Park , James Zou , Andrew Y. Ng , Jonathan H. Chen

Adversarial testing of large language models (LLMs) is crucial for their safe and responsible deployment. We introduce a novel approach for automated generation of adversarial evaluation datasets to test the safety of LLM generations on new…

Software Engineering · Computer Science 2023-12-01 Bhaktipriya Radharapu , Kevin Robinson , Lora Aroyo , Preethi Lahoti

Electronic health records (EHRs) are long, noisy, and often redundant, posing a major challenge for the clinicians who must navigate them. Large language models (LLMs) offer a promising solution for extracting and reasoning over this…

Computation and Language · Computer Science 2025-08-21 Skatje Myers , Dmitriy Dligach , Timothy A. Miller , Samantha Barr , Yanjun Gao , Matthew Churpek , Anoop Mayampurath , Majid Afshar

Vision-language models have demonstrated impressive capabilities in general medical visual question answering, yet due to limited interpretability, it remains unclear whether their predictions reflect evidence-grounded clinical reasoning or…

Computer Vision and Pattern Recognition · Computer Science 2026-05-26 Wen Ma , Fucheng Niu , Zhiting Fan , Zikai Xiao , Jiaxiang Liu , Zuozhu Liu

Artificial Intelligence (AI) has become essential in modern healthcare, with large language models (LLMs) offering promising advances in clinical decision-making. Traditional model-based approaches, including those leveraging in-context…