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Designing therapeutic peptides with tailored properties is hindered by the vastness of sequence space, limited experimental data, and poor interpretability of current generative models. To address these challenges, we introduce PepThink-R1,…

Machine Learning · Computer Science 2026-03-30 Ruheng Wang , Hang Zhang , Trieu Nguyen , Shasha Feng , Hao-Wei Pang , Xiang Yu , Li Xiao , Peter Zhiping Zhang

Large reasoning models (LRMs) are proficient at generating explicit, step-by-step reasoning sequences before producing final answers. However, such detailed reasoning can introduce substantial computational overhead and latency,…

Computation and Language · Computer Science 2025-10-10 Songjun Tu , Jiahao Lin , Qichao Zhang , Xiangyu Tian , Linjing Li , Xiangyuan Lan , Dongbin Zhao

In early developmental contexts, particularly in parent-child interaction analysis, alignment involves families and professionals such as speech-language pathologists (SLPs) who interpret children's everyday interactions from different…

Human-Computer Interaction · Computer Science 2026-03-10 Weiyan Shi , Kenny Tsu Wei Choo

As web platforms evolve towards greater personalization and emotional complexity, conversational agents must transcend superficial empathy to demonstrate identity-aware emotional reasoning. However, existing systems face two limitations:…

Computation and Language · Computer Science 2025-12-03 Jiahao Yuan , Zhiqing Cui , Hanqing Wang , Yuansheng Gao , Yucheng Zhou , Usman Naseem

Empathy is critical for effective mental health support, especially when addressing Long Counseling Texts (LCTs). However, existing Large Language Models (LLMs) often generate replies that are semantically fluent but lack the structured…

Computation and Language · Computer Science 2025-09-22 Xianrong Yao , Dong She , Chenxu Zhang , Yimeng Zhang , Yueru Sun , Noman Ahmed , Yang Gao , Zhanpeng Jin

Recent advances in large reasoning models (LRMs) show strong performance in structured domains such as mathematics and programming; however, they often lack pedagogical coherence and realistic teaching behaviors. To bridge this gap, we…

Artificial Intelligence · Computer Science 2025-05-27 Unggi Lee , Jaeyong Lee , Jiyeong Bae , Yeil Jeong , Junbo Koh , Gyeonggeon Lee , Gunho Lee , Taekyung Ahn , Hyeoncheol Kim

Amidst a shortage of qualified mental health professionals, the integration of large language models (LLMs) into psychological applications offers a promising way to alleviate the growing burden of mental health disorders. Recent…

Computation and Language · Computer Science 2025-08-25 Chongyuan Dai , Jinpeng Hu , Hongchang Shi , Zhuo Li , Xun Yang , Meng Wang

Large Language Models (LLMs) offer promising opportunities to support mental healthcare workflows, yet they often lack the structured clinical reasoning needed for reliable diagnosis and may struggle to provide the emotionally attuned…

Artificial Intelligence · Computer Science 2026-04-20 Yuqi Wu , Guangya Wan , Jingjing Li , Shengming Zhao , Lingfeng Ma , Tianyi Ye , Ion Pop , Yanbo Zhang , Jie Chen

To what degree should we ascribe cognitive capacities to Large Language Models (LLMs), such as the ability to reason about intentions and beliefs known as Theory of Mind (ToM)? Here we add to this emerging debate by (i) testing 11 base- and…

Computation and Language · Computer Science 2023-11-01 Max J. van Duijn , Bram M. A. van Dijk , Tom Kouwenhoven , Werner de Valk , Marco R. Spruit , Peter van der Putten

Purpose: Reasoning language models (RLMs) have demonstrated significant advances in solving complex reasoning tasks. We examined their potential to assess parental cooperation during CPS interventions using case reports, a case factor…

Computers and Society · Computer Science 2026-02-17 Dragan Stoll , Brian E. Perron , Zia Qi , Selina Steinmann , Nicole F. Eicher , Andreas Jud

Personalization in social robotics is critical for fostering effective human-robot interactions, yet systems often face the cold start problem, where initial user preferences or characteristics are unavailable. This paper proposes a novel…

Human-Computer Interaction · Computer Science 2025-04-03 Hamed Rahimi , Jeanne Cattoni , Meriem Beghili , Mouad Abrini , Mahdi Khoramshahi , Maribel Pino , Mohamed Chetouani

Large Language Models (LLMs) demonstrate impressive capabilities but lack robust temporal intelligence, struggling to integrate reasoning about the past with predictions and plausible generations of the future. Meanwhile, existing methods…

Computation and Language · Computer Science 2025-06-04 Zijia Liu , Peixuan Han , Haofei Yu , Haoru Li , Jiaxuan You

As the performance of larger, newer Large Language Models continues to improve for strategic Theory of Mind (ToM) tasks, the demand for these state-of-the-art models increases commensurately. However, their deployment is costly both in…

Computation and Language · Computer Science 2024-11-01 Nunzio Lore , Sepehr Ilami , Babak Heydari

Free play is a fundamental aspect of early childhood education, supporting children's cognitive, social, emotional, and motor development. However, assessing children's development during free play poses significant challenges due to the…

Artificial Intelligence · Computer Science 2025-05-07 Yuanyuan Yang , Yuan Shen , Tianchen Sun , Yangbin Xie

The proliferation of Large Language Models (LLMs) has driven considerable interest in fine-tuning them with domain-specific data to create specialized language models. Nevertheless, such domain-specific fine-tuning data often contains…

Computation and Language · Computer Science 2024-10-29 Yijia Xiao , Yiqiao Jin , Yushi Bai , Yue Wu , Xianjun Yang , Xiao Luo , Wenchao Yu , Xujiang Zhao , Yanchi Liu , Quanquan Gu , Haifeng Chen , Wei Wang , Wei Cheng

Table reasoning requires models to jointly perform comprehensive semantic understanding and precise numerical operations. Although recent large language model (LLM)-based methods have achieved promising results, most of them still rely on a…

Artificial Intelligence · Computer Science 2025-12-23 Chuang Jiang , Mingyue Cheng , Xiaoyu Tao , Qingyang Mao , Jie Ouyang , Qi Liu

While large language models show promise in medical applications, achieving expert-level clinical reasoning remains challenging due to the need for both accurate answers and transparent reasoning processes. To address this challenge, we…

Machine Learning · Computer Science 2025-09-22 Chi Liu , Derek Li , Yan Shu , Robin Chen , Derek Duan , Teng Fang , Bryan Dai

While large language models demonstrate remarkable capabilities across numerous domains, social intelligence - the capacity to perceive social cues, infer mental states, and generate appropriate responses - remains a critical challenge,…

Artificial Intelligence · Computer Science 2026-03-11 Jincenzi Wu , Yuxuan Lei , Jianxun Lian , Yitian Huang , Lexin Zhou , Haotian Li , Xing Xie , Helen Meng

We propose a multi-agent framework for modeling artificial consciousness in large language models (LLMs), grounded in psychoanalytic theory. Our \textbf{Psychodynamic Model} simulates self-awareness, preconsciousness, and unconsciousness…

Computation and Language · Computer Science 2025-10-22 Sang Hun Kim , Jongmin Lee , Dongkyu Park , So Young Lee , Yosep Chong

While black-box large language models are widely deployed, they produce generic outputs that overlook individual user preferences. Current personalization methods are fundamentally limited to response-level personalization; they only match…

Computation and Language · Computer Science 2026-03-03 Jieyong Kim , Tongyoung Kim , Soojin Yoon , Jaehyung Kim , Dongha Lee
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