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Screening patients for enrollment is a well-known, labor-intensive bottleneck that leads to under-enrollment and, ultimately, trial failures. Recent breakthroughs in large language models (LLMs) offer a promising opportunity to use…

Computation and Language · Computer Science 2026-04-30 Ziyi Chen , Mengxian Lyu , Cheng Peng , Yonghui Wu

Retrieval-augmented Large Language Models (LLMs) offer substantial benefits in enhancing performance across knowledge-intensive scenarios. However, these methods often face challenges with complex inputs and encounter difficulties due to…

Computation and Language · Computer Science 2024-10-17 Haoyu Wang , Ruirui Li , Haoming Jiang , Jinjin Tian , Zhengyang Wang , Chen Luo , Xianfeng Tang , Monica Cheng , Tuo Zhao , Jing Gao

Safe and trustworthy use of Large Language Models (LLM) in the processing of healthcare documents and scientific papers could substantially help clinicians, scientists and policymakers in overcoming information overload and focusing on the…

Retrieval-Augmented Generation (RAG) significantly improves the performance of Large Language Models (LLMs) on knowledge-intensive tasks. However, varying response quality across LLMs under RAG necessitates intelligent routing mechanisms,…

Computation and Language · Computer Science 2025-10-20 Jiarui Zhang , Xiangyu Liu , Yong Hu , Chaoyue Niu , Fan Wu , Guihai Chen

Large language models (LLMs) are transforming the way information is retrieved with vast amounts of knowledge being summarized and presented via natural language conversations. Yet, LLMs are prone to highlight the most frequently seen…

Computation and Language · Computer Science 2024-02-20 Julien Delile , Srayanta Mukherjee , Anton Van Pamel , Leonid Zhukov

Large Language Models (LLMs) have demonstrated a remarkable potential in medical knowledge acquisition and question-answering. However, LLMs can potentially hallucinate and yield factually incorrect outcomes, even with domain-specific…

Computation and Language · Computer Science 2024-07-01 Junda Wang , Zhichao Yang , Zonghai Yao , Hong Yu

Short answer assessment is a vital component of science education, allowing evaluation of students' complex three-dimensional understanding. Large language models (LLMs) that possess human-like ability in linguistic tasks are increasingly…

Computation and Language · Computer Science 2025-06-05 Yucheng Chu , Peng He , Hang Li , Haoyu Han , Kaiqi Yang , Yu Xue , Tingting Li , Joseph Krajcik , Jiliang Tang

Incentivizing the reasoning ability of Multimodal Large Language Models (MLLMs) is essential for medical applications to transparently analyze medical scans and provide reliable diagnosis. However, existing medical MLLMs rely solely on…

Computer Vision and Pattern Recognition · Computer Science 2025-10-22 Lehan Wang , Yi Qin , Honglong Yang , Xiaomeng Li

Generative AI has demonstrated strong potential in healthcare, from clinical decision support to patient-facing chatbots that improve outcomes. A critical challenge for deployment is effective human-AI communication, where content must be…

Computation and Language · Computer Science 2025-07-11 Hieu Tran , Zonghai Yao , Won Seok Jang , Sharmin Sultana , Allen Chang , Yuan Zhang , Hong Yu

Retrieval-augmented generation (RAG) systems rely on retrieval models for identifying relevant contexts and answer generation models for utilizing those contexts. However, retrievers exhibit imperfect recall and precision, limiting…

Computation and Language · Computer Science 2026-04-29 Jerry Huang , Siddarth Madala , Risham Sidhu , Cheng Niu , Hao Peng , Julia Hockenmaier , Tong Zhang

Education is one of the most promising real-world applications for Large Language Models (LLMs). However, current LLMs rely on static pre-training knowledge and lack adaptation to individual learners, while existing RAG systems fall short…

Computers and Society · Computer Science 2026-05-12 Bingxi Zhao , Jiahao Zhang , Xubin Ren , Zirui Guo , Tianzhe Chu , Yi Ma , Chao Huang

Recent studies have proposed leveraging Large Language Models (LLMs) as information retrievers through query rewriting. However, for challenging corpora, we argue that enhancing queries alone is insufficient for robust semantic matching;…

Information Retrieval · Computer Science 2025-06-24 Jingming Liu , Yumeng Li , Wei Shi , Yao-Xiang Ding , Hui Su , Kun Zhou

Low back pain (LBP) is a leading cause of disability globally. Following the onset of LBP and subsequent treatment, adequate patient education is crucial for improving functionality and long-term outcomes. Despite advancements in patient…

Artificial Intelligence · Computer Science 2024-09-24 Yi-Fei Zhao , Allyn Bove , David Thompson , James Hill , Yi Xu , Yufan Ren , Andrea Hassman , Leming Zhou , Yanshan Wang

Recent proprietary large language models (LLMs), such as GPT-4, have achieved a milestone in tackling diverse challenges in the biomedical domain, ranging from multiple-choice questions to long-form generations. To address challenges that…

Computation and Language · Computer Science 2024-06-19 Minbyul Jeong , Jiwoong Sohn , Mujeen Sung , Jaewoo Kang

Retrieval practice is a well-established pedagogical technique known to significantly enhance student learning and knowledge retention. However, generating high-quality retrieval practice questions is often time-consuming and labor…

Artificial Intelligence · Computer Science 2025-07-30 Yuan An , John Liu , Niyam Acharya , Ruhma Hashmi

Clinical decision-making requires synthesizing heterogeneous evidence, including patient histories, clinical guidelines, and trajectories of comparable cases. While large language models (LLMs) offer strong reasoning capabilities, they…

Artificial Intelligence · Computer Science 2026-03-03 Shuheng Chen , Namratha Patil , Haonan Pan , Angel Hsing-Chi Hwang , Yao Du , Ruishan Liu , Jieyu Zhao

Large language models (LLMs) have shown promise in medical question answering but often struggle with hallucinations and shallow reasoning, particularly in tasks requiring nuanced clinical understanding. Retrieval-augmented generation (RAG)…

Computation and Language · Computer Science 2025-08-25 Ziyu Wang , Elahe Khatibi , Amir M. Rahmani

Providing timely, consistent, and high-quality feedback in large-scale higher education courses remains a persistent challenge, often constrained by instructor workload and resource limitations. This study presents an LLM-powered, agentic…

Computers and Society · Computer Science 2026-01-13 Reza Vatankhah Barenji , Nazila Salimi , Sina Khoshgoftar

Medical problem-solving demands expert knowledge and intricate reasoning. Recent studies of large language models (LLMs) attempt to ease this complexity by introducing external knowledge verification through retrieval-augmented generation…

Computation and Language · Computer Science 2026-01-19 Yue Huang , Yanyuan Chen , Dexuan Xu , Chenzhuo Zhao , Weihua Yue , Yu Huang

Retrieving visual and textual information from medical literature and hospital records can enhance diagnostic accuracy for clinical image interpretation. However, multimodal retrieval-augmented diagnosis is highly challenging. We explore a…

Computer Vision and Pattern Recognition · Computer Science 2026-04-21 Nir Mazor , Tom Hope