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Motility-Induced Phase Separation (MIPS) is a distinctive phenomenon in active matter that arises from its inherent non-equilibrium nature. Despite recent progress in understanding MIPS in dry active systems, it has been debated whether…

Soft Condensed Matter · Physics 2025-10-01 Tingtao Zhou , John F. Brady

Transport at small scales is classically understood within an equilibrium framework, where dispersion theory successfully describes shear-enhanced diffusion for passive particles in the continuum limit. However, as most bacteria can move on…

Fluid Dynamics · Physics 2026-05-29 Mingyang Guan , Bowen Ling , Enhao Liu , Guoqian Chen , Zhan Wang

We study the transport of bacteria in a porous media modeled by a square channel containing one cylindrical obstacle via molecular dynamics simulations coupled to a lattice Boltzmann fluid. Our bacteria model is a rod-shaped rigid body…

Soft Condensed Matter · Physics 2020-11-30 Miru Lee , Christoph Lohrmann , Kai Szuttor , Harold Auradou , Christian Holm

Phase separation of a liquid mixture embedded within an elastic network is relevant to a wide range of natural and industrial systems, including biomolecular condensates interacting with the cytoskeleton, structural colouring in bird…

Soft Condensed Matter · Physics 2025-08-14 Oliver W. Paulin , Yicheng Qiang , David Zwicker

Cells control the size and organization of biomolecular condensates formed by liquid-liquid phase separation (LLPS), but multiple mechanisms likely contribute to this control and remain to be fully elucidated. Here we propose a…

Biological Physics · Physics 2026-04-10 Le Qiao , Peter Gispert , Lukas S. Stelzl , Friederike Schmid

Proliferation and motility are ubiquitous drivers of activity in biological systems. Here, we study a dense binary mixture of motile and proliferating particles with exclusively repulsive interactions, where homeostasis in the proliferating…

Soft Condensed Matter · Physics 2025-06-11 Lukas Hupe , Joanna M. Materska , David Zwicker , Ramin Golestanian , Bartlomiej Waclaw , Philip Bittihn

Globular proteins as well as recently synthesized colloids engineered with differently charged surface regions have in common a reduced bonding valence and a complex interaction pattern dominated by like-charge attraction and…

Soft Condensed Matter · Physics 2024-02-02 Daniele Notarmuzi , Emanuela Bianchi

Motility-induced phase separation (MIPS) is a central collective phenomenon in active matter, theoretically established in the overdamped regime. We discover that the dynamical origin of MIPS is fundamentally altered by inertia, which…

A theory is presented for the membrane junction separation induced by the adhesion between two biomimetic membranes that contain two different types of anchored junctions (receptor/ligand complexes). The analysis shows that several…

Soft Condensed Matter · Physics 2009-11-07 Hsuan-Yi Chen

The ion-activated patchy particle model is an important theoretical framework to investigate the phase behaviour of globular proteins in the presence of multivalent ions. In this work, we study and highlight the influence of patch…

Soft Condensed Matter · Physics 2025-11-13 Furio Surfaro , Peixuan Liang , Hadra Banks , Fajun Zhang , Frank Schreiber , Martin Oettel

Liquid-liquid phase separated (LLPS) states are key to compartmentalise components in the absence of membranes, however it is unclear whether LLPS condensates are actively and specifically organized in the sub-cellular space and by which…

Subcellular Processes · Quantitative Biology 2020-10-02 B. Guilhas , J. C. Walter , J. Rech , G. David , N. -O. Walliser , J. Palmeri , C. Mathieu-Demaziere , A. Parmeggiani , J. Y. Bouet , A. Le Gall , M. Nollmann

We study non-equilibrium analogues of surface phase transitions in a minimal model of active particles in contact with a purely repulsive potential barrier that mimics a thin porous membrane. Under conditions of bulk motility-induced phase…

Statistical Mechanics · Physics 2021-12-15 Francesco Turci , Nigel B. Wilding

Osmotic deflation of vesicles enclosing two liquid phases can lead to bulging of one of the phases from the vesicle body. This budding process is preceded by a complete to partial wetting transition of one of the liquid phases on the…

Soft Condensed Matter · Physics 2012-01-17 Yanhong Li , Halim Kusumaatmaja , Reinhard Lipowsky , Rumiana Dimova

Motivated by the observations of intracellular phase separations and the wetting of cell membranes by protein droplets, we study the nonequilibrium surface wetting by Monte Carlo simulations of a lattice gas model involving particle…

Biological Physics · Physics 2022-06-23 Kyosuke Adachi , Kyogo Kawaguchi

Hypothesis: Bacterial contamination of surfaces poses a major threat to public health. Designing effective antibacterial or self-cleaning surfaces requires understanding how bacteria-laden droplets interact with solid substrates and how…

Soft Condensed Matter · Physics 2025-10-29 Sirshendu Misra , Sudip Shyam , Priyam Chakraborty , Sushanta K. Mitra

We present theoretical analyses and numerical simulations for the adhesion-induced phase separation of multi-component membranes with two types of ligand-receptor complexes (junctions). We show that after integrating all possible…

Soft Condensed Matter · Physics 2007-05-23 Jia-Yuan Wu

We present a hydrodynamic theory for systems of dipolar active Brownian particles which, in the regime of weak dipolar coupling, predicts the onset of motility-induced phase separation (MIPS), consistent with Brownian dynamics (BD)…

Soft Condensed Matter · Physics 2022-03-29 Elena Sesé-Sansa , Guo-Jun Liao , Demian Levis , Ignacio Pagonabarraga , Sabine H. L. Klapp

We present a theory for the interfacial wetting phase behaviour of binary liquid mixtures on rigid solid substrates, applicable to both miscible and immiscible mixtures. In particular, we calculate the binding potential as a function of the…

Soft Condensed Matter · Physics 2024-02-02 Mounirah Areshi , Dmitri Tseluiko , Uwe Thiele , Benjamin D. Goddard , Andrew J. Archer

The phase behavior of membrane proteins stems from a complex synergy with the amphiphilic molecules required for their solubilization. We show that ionization of a pH-sensitive surfactant, LDAO, bound to a bacterial photosynthetic protein,…

Soft Condensed Matter · Physics 2009-11-07 R. Piazza , M. Pierno , E. Vignati , G. Venturoli , F. Francia , A. Mallardi , G. Palazzo

Liquid-liquid phase separation (LLPS) of protein solutions is governed by highly complex protein-protein interactions. Nevertheless, it has been suggested that based on the extended law of corresponding states (ELCS), as proposed for…

Soft Condensed Matter · Physics 2023-02-08 Jan Hansen , Stefan U. Egelhaaf , Florian Platten