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Obesity does not emerge abruptly; rather, it develops gradually over extended periods. The gradual progression often prevents early recognition of physiological changes until excess adiposity is established. A common belief is that weight…

Quantitative Methods · Quantitative Biology 2026-03-18 Soheil Saghafi , Gari D. Clifford

The global prevalence of diabetes, particularly type 2 diabetes mellitus (T2DM), is rapidly increasing, posing significant health and economic challenges. T2DM not only disrupts blood glucose regulation but also damages vital organs such as…

Machine Learning · Computer Science 2025-06-09 Praveen Kumar , Vincent T. Metzger , Scott A. Malec

Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder characterized by progressive cognitive decline and widespread epigenetic dysregulation in the brain. DNA methylation, as a stable yet dynamic epigenetic modification,…

Genomics · Quantitative Biology 2026-01-05 Gang Qu , Guanghao Li , Zhongming Zhao

This study proposes a Transformer-based longitudinal modeling method to address challenges in clinical risk classification with heterogeneous Electronic Health Record (EHR) data, including irregular temporal patterns, large modality…

Machine Learning · Computer Science 2025-11-07 Anzhuo Xie , Wei-Chen Chang

A task of vital clinical importance, within Diabetes management, is the prevention of hypo/hyperglycemic events. Increasingly adopted Continuous Glucose Monitoring (CGM) devices offer detailed, non-intrusive and real time insights into a…

Machine Learning · Computer Science 2023-03-09 Jakub J. Dylag

Disease progression varies with age and is influenced by underlying genetic, biochemical, and hormonal etiologies, suggesting the need for tailored monitoring, care, and medication beyond standard clinical guidelines. Specifically, in…

Machine Learning · Computer Science 2026-04-28 Beyza Cinar , Maria Maleshkova

Prediabetes is a common health condition that often goes undetected until it progresses to type 2 diabetes. Early identification of prediabetes is essential for timely intervention and prevention of complications. This research explores the…

Signal Processing · Electrical Eng. & Systems 2025-04-08 Dimitra Tatli , Vasileios Papapanagiotou , Aris Liakos , Apostolos Tsapas , Anastasios Delopoulos

Quantitative cardiac magnetic resonance T1 and T2 mapping enable myocardial tissue characterisation but the lengthy scan times restrict their widespread clinical application. We propose a deep learning method that incorporates a time…

Signal Processing · Electrical Eng. & Systems 2023-10-02 Fanwen Wang , Michael Tanzer , Mengyun Qiao , Wenjia Bai , Daniel Rueckert , Guang Yang , Sonia Nielles-Vallespin

Metabolomic based approaches have gained much attention in recent years due to their promising potential to deliver objective tools for assessment of food intake. In particular, multiple biomarkers have emerged for single foods. However,…

Methodology · Statistics 2021-05-10 Silvia D'Angelo , Lorraine Brennan , Isobel Claire Gormley

Introduction: Identification of blood-based metabolic changes might provide early and easy-to-obtain biomarkers. Methods: We included 127 AD patients and 121 controls with CSF-biomarker-confirmed diagnosis (cut-off tau/A$\beta_{42}$: 0.52).…

Due to the sensitive nature of diabetes-related data, preventing them from being shared between studies, progress in the field of glucose prediction is hard to assess. To address this issue, we present GLYFE (GLYcemia Forecasting…

Signal Processing · Electrical Eng. & Systems 2020-06-30 Maxime De Bois , Mehdi Ammi , Mounîm A. El Yacoubi

Deep learning models achieve state-of-the art results in predicting blood glucose trajectories, with a wide range of architectures being proposed. However, the adaptation of such models in clinical practice is slow, largely due to the lack…

Machine Learning · Computer Science 2023-03-08 Renat Sergazinov , Mohammadreza Armandpour , Irina Gaynanova

Imaging-derived phenotypes (IDPs) summarize multi-organ physiology but provide only static snapshots of diseases that evolve over time. In contrast, longitudinal electronic health records encode disease trajectories through temporal…

Information Retrieval · Computer Science 2026-05-13 Zian Wang , Lizhen Lan , Guangming Wang , Haosen Zhang , Minxuan Xu , Qing Li , Tianxing He , Mo Yang , Wenyue Mao , Yajing Zhang , Yan Li , Chengyan Wang

This study addresses the challenges of symptom evolution complexity and insufficient temporal dependency modeling in Parkinson's disease progression prediction. It proposes a unified prediction framework that integrates structural…

Machine Learning · Computer Science 2025-08-22 Jiacheng Hu , Bo Zhang , Ting Xu , Haifeng Yang , Min Gao

Diabetes is a chronic metabolic disorder characterized by persistently high blood glucose levels (BGLs), leading to severe complications such as cardiovascular disease, neuropathy, and retinopathy. Predicting BGLs enables patients to…

Deep learning has yet to revolutionize general practices in healthcare, despite promising results for some specific tasks. This is partly due to data being in insufficient quantities hurting the training of the models. To address this…

Computer Vision and Pattern Recognition · Computer Science 2020-06-30 Maxime De Bois , Mounîm A. El Yacoubi , Mehdi Ammi

Recent advances in transformer architectures have revolutionised natural language processing, but their application to healthcare domains presents unique challenges. Patient timelines are characterised by irregular sampling, variable…

Computation and Language · Computer Science 2025-05-26 Linglong Qian , Zina Ibrahim

Type 1 Diabetes is a chronic autoimmune condition in which the immune system attacks and destroys insulin-producing beta cells in the pancreas, resulting in little to no insulin production. Insulin helps glucose in your blood enter your…

Quantitative Methods · Quantitative Biology 2025-02-04 Soon Jynn Chu , Nalaka Amarasiri , Sandesh Giri , Priyata Kafle

People with type 1 diabetes (T1D) lack the ability to produce the insulin their bodies need. As a result, they must continually make decisions about how much insulin to self-administer to adequately control their blood glucose levels.…

Machine Learning · Computer Science 2020-09-22 Ian Fox , Joyce Lee , Rodica Pop-Busui , Jenna Wiens

The early detection and prediction of cardiovascular diseases are crucial for reducing the severe morbidity and mortality associated with these conditions worldwide. A multi-headed self-attention mechanism, widely used in natural language…