English
Related papers

Related papers: Tool Choice Matters: Evaluating edgeR vs. DESeq2 f…

200 papers

Edge detection serves as a critical foundation for numerous computer vision applications, including object detection, semantic segmentation, and image editing, by extracting essential structural cues that define object boundaries and…

Computer Vision and Pattern Recognition · Computer Science 2025-08-19 Yuanbin Fu , Liang Li , Xiaojie Guo

This study evaluates the concordance between RNA sequencing (RNA-Seq) and NanoString technologies for gene expression analysis in non-human primates (NHPs) infected with Ebola virus (EBOV). We performed a detailed comparison of both…

Genomics · Quantitative Biology 2024-11-01 Mostafa Rezapour , Aarthi Narayanan , Wyatt H. Mowery , Metin Nafi Gurcan

A potent class of generative models known as Diffusion Probabilistic Models (DPMs) has become prominent. A forward diffusion process adds gradually noise to data, while a model learns to gradually denoise. Sampling from pre-trained DPMs is…

Machine Learning · Computer Science 2023-10-27 Martin Gonzalez , Nelson Fernandez , Thuy Tran , Elies Gherbi , Hatem Hajri , Nader Masmoudi

Under stringent model type and variable distribution assumptions, differentiable score-based causal discovery methods learn a directed acyclic graph (DAG) from observational data by evaluating candidate graphs over an average score…

Machine Learning · Computer Science 2023-03-07 An Zhang , Fangfu Liu , Wenchang Ma , Zhibo Cai , Xiang Wang , Tat-seng Chua

Differential equations (DEs) are crucial for modeling the evolution of natural or engineered systems. Traditionally, the parameters in DEs are adjusted to fit data from system observations. However, in fields such as politics, economics,…

Machine Learning · Computer Science 2024-12-30 Hyunwoo Cho , Sung Woong Cho , Hyeontae Jo , Hyung Ju Hwang

Working towards the development of an evolvable cancer treatment simulator, the investigation of Differential Evolution was considered, motivated by the high efficiency of variations of this technique in real-valued problems. A basic DE…

Neural and Evolutionary Computing · Computer Science 2020-03-27 Michail-Antisthenis Tsompanas , Larry Bull , Andrew Adamatzky , Igor Balaz

Motivation: Measurements of gene expression over time enable the reconstruction of transcriptional networks. However, Bayesian networks and many other current reconstruction methods rely on assumptions that conflict with the differential…

Molecular Networks · Quantitative Biology 2009-07-02 D. R. Bickel , Z. Montazeri , P. -C. Hsieh , M. Beatty , S. J. Lawit , N. J. Bate

The detection of differentially expressed (DE) genes is one of the most commonly studied problems in bioinformatics. For example, the identification of DE genes between distinct disease phenotypes is an important first step in understanding…

Methodology · Statistics 2013-07-31 S. K. Ng , G. J. McLachlan , K. Wang , Z. Nagymanyoki , S. Liu , S. -W. Ng

Accurate and robust drug response prediction is of utmost importance in precision medicine. Although many models have been developed to utilize the representations of drugs and cancer cell lines for predicting cancer drug responses (CDR),…

Quantitative Methods · Quantitative Biology 2023-11-22 Xiaoqiong Xia , Chaoyu Zhu , Yuqi Shan , Fan Zhong , Lei Liu

In a given classification task, the accuracy of the learner is often hampered by finiteness of the training set, high-dimensionality of the feature space and severe overlap between classes. In the context of interpretable learners, with…

Machine Learning · Computer Science 2025-04-03 Marco Canducci , Lida Abdi , Alessandro Prete , Roland J. Veen , Michael Biehl , Wiebke Arlt , Peter Tino

Straight-forward conformation generation models, which generate 3-D structures directly from input molecular graphs, play an important role in various molecular tasks with machine learning, such as 3D-QSAR and virtual screening in drug…

Biomolecules · Quantitative Biology 2022-03-16 Shuwen Yang , Tianyu Wen , Ziyao Li , Guojie Song

Recent work synthesizes agentic tasks for post-training tool-using LLMs, yet robust generalization under shifts in tasks and toolsets remains an open challenge. We trace this brittleness to insufficient diversity in synthesized tasks.…

Artificial Intelligence · Computer Science 2026-03-13 Aili Chen , Chi Zhang , Junteng Liu , Jiangjie Chen , Chengyu Du , Yunji Li , Ming Zhong , Qin Wang , Zhengmao Zhu , Jiayuan Song , Ke Ji , Junxian He , Pengyu Zhao , Yanghua Xiao

The advent of high--throughput transcription profiling technologies has enabled identification of genes and pathways associated with disease, providing new avenues for precision medicine. A key challenge is to analyze this data in the…

Quantitative Methods · Quantitative Biology 2019-01-11 Sahil D. Shah , Rosemary Braun

As gene expression measurement technology is shifting from microarrays to sequencing, the statistical tools available for their analysis must be adapted since RNA-seq data are measured as counts. Recently, it has been proposed to tackle the…

Applications · Statistics 2022-11-10 Denis Agniel , Boris P Hejblum

Electroencephalography (EEG) is an objective tool for emotion recognition with promising applications. However, the scarcity of labeled data remains a major challenge in this field, limiting the widespread use of EEG-based emotion…

Signal Processing · Electrical Eng. & Systems 2024-08-05 Weishan Ye , Zhiguo Zhang , Fei Teng , Min Zhang , Jianhong Wang , Dong Ni , Fali Li , Peng Xu , Zhen Liang

Distilling demonstration effects into hidden-space interventions offers a lightweight alternative to full finetuning. However, existing multimodal variants are mostly evaluated on short-form tasks, where outputs end after a few tokens.…

Computation and Language · Computer Science 2026-05-27 Ning Wu , Rui Liu , Xinkun Lin , Weixing Chen , Jinxi Xiang , Tao Wei , Lina Yao , Mingjie Li

Mutational signatures connect characteristic mutational patterns in the genome with biological or chemical processes that take place in cancers. Analysis of mutational signatures can help elucidate tumor evolution, prognosis, and…

Genomics · Quantitative Biology 2024-12-09 Matúš Medo , Charlotte K. Y. Ng , Michaela Medová

Emotions are crucial in human life, influencing perceptions, relationships, behaviour, and choices. Emotion recognition using Electroencephalography (EEG) in the Brain-Computer Interface (BCI) domain presents significant challenges,…

Human-Computer Interaction · Computer Science 2025-12-12 Gourav Siddhad , Masakazu Iwamura , Partha Pratim Roy

Decision trees and random forest remain highly competitive for classification on medium-sized, standard datasets due to their robustness, minimal preprocessing requirements, and interpretability. However, a single tree suffers from high…

Machine Learning · Statistics 2025-12-02 Cencheng Shen , Yuexiao Dong , Carey E. Priebe

Irregular sampling of time series in electronic health records (EHRs) is one of the main challenges for developing machine learning models. Additionally, the pattern of missing data in certain clinical variables is not at random but depends…

Machine Learning · Computer Science 2024-06-17 Hojjat Karami , David Atienza , Anisoara Ionescu