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Image segmentation is crucial in many computational pathology pipelines, including accurate disease diagnosis, subtyping, outcome, and survivability prediction. The common approach for training a segmentation model relies on a pre-trained…

Computer Vision and Pattern Recognition · Computer Science 2025-04-10 Sachin Kumar Danisetty , Alexandros Graikos , Srikar Yellapragada , Dimitris Samaras

Foundation models are rapidly being developed for computational pathology applications. However, it remains an open question which factors are most important for downstream performance with data scale and diversity, model size, and training…

Deep neural networks have achieved impressive performance in a wide variety of medical imaging tasks. However, these models often fail on data not used during training, such as data originating from a different medical centre. How to…

Image and Video Processing · Electrical Eng. & Systems 2022-12-05 Joona Pohjonen , Carolin Stürenberg , Atte Föhr , Reija Randen-Brady , Lassi Luomala , Jouni Lohi , Esa Pitkänen , Antti Rannikko , Tuomas Mirtti

Recent studies in pathology foundation models have shown that scaling training data, diversifying cancer types, and increasing model size consistently improve their performance. However, giga-scale foundation models, which are trained on…

Computer Vision and Pattern Recognition · Computer Science 2026-01-06 Yesung Cho , Sungmin Lee , Geongyu Lee , Minkyung Lee , Jongbae Park , Dongmyung Shin

Computational analysis of whole slide images (WSIs) has seen significant research progress in recent years, with applications ranging across important diagnostic and prognostic tasks such as survival or cancer subtype prediction. Many…

Computer Vision and Pattern Recognition · Computer Science 2024-11-28 Zak Buzzard , Konstantin Hemker , Nikola Simidjievski , Mateja Jamnik

The Mixup scheme suggests mixing a pair of samples to create an augmented training sample and has gained considerable attention recently for improving the generalizability of neural networks. A straightforward and widely used extension of…

Computer Vision and Pattern Recognition · Computer Science 2021-12-17 Joonhyung Park , June Yong Yang , Jinwoo Shin , Sung Ju Hwang , Eunho Yang

The standard practice in Generative Adversarial Networks (GANs) discards the discriminator during sampling. However, this sampling method loses valuable information learned by the discriminator regarding the data distribution. In this work,…

Machine Learning · Computer Science 2019-11-25 Yuejiang Liu , Parth Kothari , Alexandre Alahi

Foundation models in digital pathology use massive datasets to learn useful compact feature representations of complex histology images. However, there is limited transparency into what drives the correlation between dataset size and…

Computational pathology, which involves analyzing whole slide images for automated cancer diagnosis, relies on multiple instance learning, where performance depends heavily on the feature extractor and aggregator. Recent Pathology…

Computer Vision and Pattern Recognition · Computer Science 2025-05-22 Conghao Xiong , Hao Chen , Joseph J. Y. Sung

Many computer vision systems require low-cost segmentation algorithms based on deep learning, either because of the enormous size of input images or limited computational budget. Common solutions uniformly downsample the input images to…

Computer Vision and Pattern Recognition · Computer Science 2022-08-19 Chen Jin , Ryutaro Tanno , Thomy Mertzanidou , Eleftheria Panagiotaki , Daniel C. Alexander

The deployment of foundation models for medical imaging has demonstrated considerable success. However, their training overheads associated with downstream tasks remain substantial due to the size of the image encoders employed, and the…

Computer Vision and Pattern Recognition · Computer Science 2025-04-04 Chengxi Zeng , Yuxuan Jiang , Fan Zhang , Alberto Gambaruto , Tilo Burghardt

In this paper, we study the maximum entropy sampling problem (MESP) and its variants. MESP seeks to identify a small subset of variables that maximizes the determinant of a covariance submatrix, and is a fundamental model in optimal…

Optimization and Control · Mathematics 2026-04-14 Lingqing Shen , Fatma Kılınç-Karzan

Deep learning techniques have become widely utilized in histopathology image classification due to their superior performance. However, this success heavily relies on the availability of substantial labeled data, which necessitates…

Image and Video Processing · Electrical Eng. & Systems 2024-10-15 Meng Li , Chaoyi Li , Can Peng , Brian C. Lovell

Unsupervised cross-modality medical image adaptation aims to alleviate the severe domain gap between different imaging modalities without using the target domain label. A key in this campaign relies upon aligning the distributions of source…

Computer Vision and Pattern Recognition · Computer Science 2022-09-07 Zixian Su , Kai Yao , Xi Yang , Qiufeng Wang , Yuyao Yan , Jie Sun , Kaizhu Huang

Variance-reduced stochastic gradient methods have gained popularity in recent times. Several variants exist with different strategies for the storing and sampling of gradients and this work concerns the interactions between these two…

Optimization and Control · Mathematics 2022-10-19 Martin Morin , Pontus Giselsson

The ability to learn sequentially from different data sites is crucial for a deep network in solving practical medical image diagnosis problems due to privacy restrictions and storage limitations. However, adapting on incoming site leads to…

Computer Vision and Pattern Recognition · Computer Science 2025-04-28 Dunyuan Xu , Xi Wang , Jingyang Zhang , Pheng-Ann Heng

Accurate brain tumor diagnosis relies on the assessment of multiple Magnetic Resonance Imaging (MRI) sequences. However, in clinical practice, the acquisition of certain sequences may be affected by factors like motion artifacts or contrast…

Image and Video Processing · Electrical Eng. & Systems 2025-05-30 Moinak Bhattacharya , Saumya Gupta , Annie Singh , Chao Chen , Gagandeep Singh , Prateek Prasanna

Augmentation by generative modelling yields a promising alternative to the accumulation of surgical data, where ethical, organisational and regulatory aspects must be considered. Yet, the joint synthesis of (image, mask) pairs for…

Computer Vision and Pattern Recognition · Computer Science 2025-07-02 Yannik Frisch , Christina Bornberg , Moritz Fuchs , Anirban Mukhopadhyay

This paper is concerned with the sample efficiency of reinforcement learning, assuming access to a generative model (or simulator). We first consider $\gamma$-discounted infinite-horizon Markov decision processes (MDPs) with state space…

Machine Learning · Computer Science 2025-03-18 Gen Li , Yuting Wei , Yuejie Chi , Yuxin Chen

Deep learning models for medical image segmentation suffer significant performance drops due to distribution shifts, but the causal mechanisms behind these drops remain poorly understood. We extend causal attribution frameworks to…

Image and Video Processing · Electrical Eng. & Systems 2025-12-11 Pedro M. Gordaliza , Nataliia Molchanova , Jaume Banus , Thomas Sanchez , Meritxell Bach Cuadra