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The complexity and opacity of neural networks (NNs) pose significant challenges, particularly in high-stakes fields such as healthcare, finance, and law, where understanding decision-making processes is crucial. To address these issues, the…

Machine Learning · Computer Science 2025-11-13 Helena Monke , Benjamin Sae-Chew , Benjamin Fresz , Marco F. Huber

The proposed framework named IDEAL (Interpretable-by-design DEep learning ALgorithms) recasts the standard supervised classification problem into a function of similarity to a set of prototypes derived from the training data, while taking…

Machine Learning · Computer Science 2023-11-21 Plamen Angelov , Dmitry Kangin , Ziyang Zhang

Prognostic and diagnostic AI-based medical devices hold immense promise for advancing healthcare, yet their rapid development has outpaced the establishment of appropriate validation methods. Existing approaches often fall short in…

Machine Learning · Computer Science 2024-09-10 Florian Hellmeier , Kay Brosien , Carsten Eickhoff , Alexander Meyer

Deep learning models have achieved high performance in medical applications, however, their adoption in clinical practice is hindered due to their black-box nature. Self-explainable models, like prototype-based models, can be especially…

Computer Vision and Pattern Recognition · Computer Science 2024-07-22 Shreyasi Pathak , Jörg Schlötterer , Jeroen Veltman , Jeroen Geerdink , Maurice van Keulen , Christin Seifert

The integration of Artificial Intelligence in the development of computer systems presents a new challenge: make intelligent systems explainable to humans. This is especially vital in the field of health and well-being, where transparency…

Deployments of artificial intelligence in medical diagnostics mandate not just accuracy and efficacy but also trust, emphasizing the need for explainability in machine decisions. The recent trend in automated medical image diagnostics leans…

Computer Vision and Pattern Recognition · Computer Science 2024-03-12 Ugur Demir , Debesh Jha , Zheyuan Zhang , Elif Keles , Bradley Allen , Aggelos K. Katsaggelos , Ulas Bagci

Survival analysis plays a vital role in making clinical decisions. However, the models currently in use are often difficult to interpret, which reduces their usefulness in clinical settings. Prototype learning presents a potential solution,…

Computer Vision and Pattern Recognition · Computer Science 2025-10-08 Shuo Jiang , Zhuwen Chen , Liaoman Xu , Yanming Zhu , Changmiao Wang , Jiong Zhang , Feiwei Qin , Yifei Chen , Zhu Zhu

The lack of explainability of deep learning models limits the adoption of such models in clinical practice. Prototype-based models can provide inherent explainable predictions, but these have predominantly been designed for classification…

Computer Vision and Pattern Recognition · Computer Science 2023-11-08 Linde S. Hesse , Nicola K. Dinsdale , Ana I. L. Namburete

We introduce ProtoPool, an interpretable image classification model with a pool of prototypes shared by the classes. The training is more straightforward than in the existing methods because it does not require the pruning stage. It is…

Computer Vision and Pattern Recognition · Computer Science 2022-09-07 Dawid Rymarczyk , Łukasz Struski , Michał Górszczak , Koryna Lewandowska , Jacek Tabor , Bartosz Zieliński

Multimodal molecular representation learning, which jointly models molecular graphs and their textual descriptions, enhances predictive accuracy and interpretability by enabling more robust and reliable predictions of drug toxicity,…

Machine Learning · Computer Science 2025-10-21 Yingxu Wang , Kunyu Zhang , Jiaxin Huang , Nan Yin , Siwei Liu , Eran Segal

Remote screening of respiratory diseases has been widely studied as a non-invasive and early instrument for diagnosis purposes, especially in the pandemic. The respiratory sound classification task has been realized with numerous deep…

Sound · Computer Science 2022-02-08 Zhao Ren , Thanh Tam Nguyen , Wolfgang Nejdl

Prototype-based interpretability methods provide intuitive explanations of model prediction by comparing samples to a reference set of memorized exemplars or typical representatives in terms of similarity. In the field of sequential data…

Machine Learning · Computer Science 2023-03-20 Yifei Zhang , Neng Gao , Cunqing Ma

Intensive Care Unit (ICU) mortality prediction, which estimates a patient's mortality status at discharge using EHRs collected early in an ICU admission, is vital in critical care. For this task, predictive accuracy alone is insufficient;…

Machine Learning · Computer Science 2025-10-15 Qingwen Li , Xiaohang Zhao , Xiao Han , Hailiang Huang , Lanjuan Liu

Effective communication in serious illness and palliative care is essential but often under-taught due to limited access to training resources like standardized patients. We present PAL (Palliative Assisted Learning-bot), a conversational…

Human-Computer Interaction · Computer Science 2025-11-12 Neil K. R. Sehgal , Hita Kambhamettu , Allen Chang , Andrew Zhu , Lyle Ungar , Sharath Chandra Guntuku

This paper contributes with a pragmatic evaluation framework for explainable Machine Learning (ML) models for clinical decision support. The study revealed a more nuanced role for ML explanation models, when these are pragmatically embedded…

Artificial Intelligence · Computer Science 2022-12-22 Oskar Wysocki , Jessica Katharine Davies , Markel Vigo , Anne Caroline Armstrong , Dónal Landers , Rebecca Lee , André Freitas

The wide-spread adoption of representation learning technologies in clinical decision making strongly emphasizes the need for characterizing model reliability and enabling rigorous introspection of model behavior. While the former need is…

Machine Learning · Computer Science 2020-05-01 Jayaraman J. Thiagarajan , Prasanna Sattigeri , Deepta Rajan , Bindya Venkatesh

Histo-genomic multimodal survival prediction has garnered growing attention for its remarkable model performance and potential contributions to precision medicine. However, a significant challenge in clinical practice arises when only…

Machine Learning · Computer Science 2025-03-17 Fengchun Liu , Linghan Cai , Zhikang Wang , Zhiyuan Fan , Jin-gang Yu , Hao Chen , Yongbing Zhang

Learning effective representations in image-based environments is crucial for sample efficient Reinforcement Learning (RL). Unfortunately, in RL, representation learning is confounded with the exploratory experience of the agent -- learning…

Machine Learning · Computer Science 2021-07-21 Denis Yarats , Rob Fergus , Alessandro Lazaric , Lerrel Pinto

Contrastive learning based vision-language joint pre-training has emerged as a successful representation learning strategy. In this paper, we present a prototype representation learning framework incorporating both global and local…

Computer Vision and Pattern Recognition · Computer Science 2024-03-12 Pujin Cheng , Li Lin , Junyan Lyu , Yijin Huang , Wenhan Luo , Xiaoying Tang

Prototypical Learning is based on the idea that there is a point (which we call prototype) around which the embeddings of a class are clustered. It has shown promising results in scenarios with little labeled data or to design explainable…

Machine Learning · Computer Science 2024-06-25 Antonio Almudévar , Théo Mariotte , Alfonso Ortega , Marie Tahon , Luis Vicente , Antonio Miguel , Eduardo Lleida