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The translation of artificial intelligence (AI) systems into clinical practice requires bridging fundamental gaps between explainable AI theory, clinician expectations, and governance requirements. While conceptual frameworks define what…

Computers and Society · Computer Science 2025-11-05 Alexander Bakumenko , Aaron J. Masino , Janine Hoelscher

Explainable Artificial Intelligence (AI) methods are designed to provide information about how AI-based models make predictions. In healthcare, there is a widespread expectation that these methods will provide relevant and accurate…

While deep learning has achieved impressive performance in time series forecasting, it becomes increasingly crucial to understand its decision-making process for building trust in high-stakes scenarios. Existing interpretable models often…

Machine Learning · Computer Science 2026-03-02 Ziheng Peng , Shijie Ren , Xinyue Gu , Linxiao Yang , Xiting Wang , Liang Sun

The impact of machine learning models on healthcare will depend on the degree of trust that healthcare professionals place in the predictions made by these models. In this paper, we present a method to provide people with clinical expertise…

Machine Learning · Computer Science 2021-03-05 Aniruddh Raghu , John Guttag , Katherine Young , Eugene Pomerantsev , Adrian V. Dalca , Collin M. Stultz

We propose a novel inherently interpretable machine learning method that bases decisions on few relevant examples that we call prototypes. Our method, ProtoAttend, can be integrated into a wide range of neural network architectures…

Machine Learning · Computer Science 2019-09-27 Sercan O. Arik , Tomas Pfister

Multimodal self-supervised pretraining offers a promising route to cancer prognosis by integrating histopathology whole-slide images, gene expression, and pathology reports, yet most existing approaches require fully paired and complete…

Machine Learning · Computer Science 2026-04-08 Kai Yu , Shuang Zhou , Yiran Song , Zaifu Zhan , Jie Peng , Kaixiong Zhou , Tianlong Chen , Feng Xie , Meng Wang , Huazhu Fu , Mingquan Lin , Rui Zhang

We propose ProtoArgNet, a novel interpretable deep neural architecture for image classification in the spirit of prototypical-part-learning as found, e.g., in ProtoPNet. While earlier approaches associate every class with multiple…

Computer Vision and Pattern Recognition · Computer Science 2025-04-16 Hamed Ayoobi , Nico Potyka , Francesca Toni

Prototypical networks aim to build intrinsically explainable models based on the linear summation of concepts. Concepts are coherent entities that we, as humans, can recognize and associate with a certain object or entity. However,…

Computer Vision and Pattern Recognition · Computer Science 2024-12-17 Hugues Turbé , Mina Bjelogrlic , Gianmarco Mengaldo , Christian Lovis

Machine Learning (ML) has recently shown tremendous success in modeling various healthcare prediction tasks, ranging from disease diagnosis and prognosis to patient treatment. Due to the sensitive nature of medical data, privacy must be…

Machine Learning · Computer Science 2024-10-01 Alejandro Guerra-Manzanares , L. Julian Lechuga Lopez , Michail Maniatakos , Farah E. Shamout

Prototype models are an important method for explainable artificial intelligence (XAI) and interpretable machine learning. In this paper, we perform an in-depth analysis of a set of prominent prototype models including ProtoPNet, ProtoPool…

Machine Learning · Computer Science 2025-11-24 Philipp Schlinge , Steffen Meinert , Martin Atzmueller

Deep neural networks have achieved remarkable performance in various text-based tasks but often lack interpretability, making them less suitable for applications where transparency is critical. To address this, we propose ProtoLens, a novel…

Computation and Language · Computer Science 2024-10-25 Bowen Wei , Ziwei Zhu

Decision-making processes in healthcare can be highly complex and challenging. Machine Learning tools offer significant potential to assist in these processes. However, many current methodologies rely on complex models that are not easily…

Artificial Intelligence · Computer Science 2025-03-24 Alessio Cascione , Mattia Setzu , Federico A. Galatolo , Mario G. C. A. Cimino , Riccardo Guidotti

This paper claims that machine learning models deployed in high stakes domains such as medicine must be interpretable, shareable, reproducible and accountable. We argue that these principles should form the foundational design criteria for…

Machine Learning · Computer Science 2025-08-25 Ayyüce Begüm Bektaş , Mithat Gönen

Artificial intelligence (AI) has huge potential to improve the health and well-being of people, but adoption in clinical practice is still limited. Lack of transparency is identified as one of the main barriers to implementation, as…

Artificial Intelligence · Computer Science 2021-01-06 Aniek F. Markus , Jan A. Kors , Peter R. Rijnbeek

In time-series domains where both predictive performance and interpretability are essential, deep neural networks achieve strong results but provide limited insight into how their predictions are made. Projection-based prototype networks…

Machine Learning · Computer Science 2026-05-11 Steven Song , Sahil Sethi , Brett Beaulieu-Jones , Robert L. Grossman

Predicting health risks from electronic health records (EHR) is a topic of recent interest. Deep learning models have achieved success by modeling temporal and feature interaction. However, these methods learn insufficient representations…

Machine Learning · Computer Science 2023-12-19 Zhihao Yu , Chaohe Zhang , Yasha Wang , Wen Tang , Jiangtao Wang , Liantao Ma

In healthcare there is a pursuit for employing interpretable algorithms to assist healthcare professionals in several decision scenarios. Following the Predictive, Descriptive and Relevant (PDR) framework, the definition of interpretable…

Neural network architectures are most often conceptually designed and described in visual terms, but are implemented by writing error-prone code. PrototypeML is a machine learning development environment that bridges the dichotomy between…

Machine Learning · Computer Science 2020-07-03 Daniel Reiss Harris

One of the major challenges in machine learning nowadays is to provide predictions with not only high accuracy but also user-friendly explanations. Although in recent years we have witnessed increasingly popular use of deep neural networks…

Machine Learning · Computer Science 2019-07-24 Yao Ming , Panpan Xu , Huamin Qu , Liu Ren

As machine learning (ML) models and datasets increase in complexity, the demand for methods that enhance explainability and interpretability becomes paramount. Prototypes, by encapsulating essential characteristics within data, offer…

Machine Learning · Computer Science 2024-08-20 Orfeas Menis-Mastromichalakis , Giorgos Filandrianos , Jason Liartis , Edmund Dervakos , Giorgos Stamou