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Unobserved confounders are a long-standing issue in causal inference using propensity score methods. This study proposed nonparametric indices to quantify the impact of unobserved confounders through pseudo-experiments with an application…

Methodology · Statistics 2020-08-27 Beilin Jia , Donglin Zeng , Qing Yang , Wei Pan

An acyclic causal structure can be described with directed acyclic graph (DAG), where arrows indicate the possibility of direct causation. The task of learning this structure from data is known as "causal discovery." Diverse populations or…

Machine Learning · Computer Science 2024-10-17 Bijan Mazaheri , Spencer Gordon , Yuval Rabani , Leonard Schulman

Unobserved confounding prevents standard covariate adjustment from identifying causal response functions in observational studies. Proxy causal learning addresses this problem through bridge equations involving treatment- and…

Machine Learning · Computer Science 2026-05-12 Bariscan Bozkurt , Alexandre Galashov , Dimitri Meunier , Zikai Shen , Arthur Gretton , Houssam Zenati

Predicting how cells respond to genetic perturbations is fundamental to understanding gene function, disease mechanisms, and therapeutic development. While recent deep learning approaches have shown promise in modeling single-cell…

Machine Learning · Computer Science 2026-03-10 Andrea Giuseppe Di Francesco , Andrea Rubbi , Pietro Liò

Distinguishing causal connections from correlations is important in many scenarios. However, the presence of unobserved variables, such as the latent confounder, can introduce bias in conditional independence testing commonly employed in…

Methodology · Statistics 2024-05-03 Mingzhou Liu , Xinwei Sun , Yu Qiao , Yizhou Wang

Leveraging deep learning for causal discovery in time series remains challenging because existing neural methods predominantly rely on component-wise architectures that fail to capture shared system dynamics or employ decoupled post-hoc…

Machine Learning · Computer Science 2026-05-11 Omar Muhammad , Pasupuleti Dhruv Shivkant , Deepak N. Subramani

Recent work has shown promising results in causal discovery by leveraging interventional data with gradient-based methods, even when the intervened variables are unknown. However, previous work assumes that the correspondence between…

Machine Learning · Computer Science 2022-07-12 Gonçalo R. A. Faria , André F. T. Martins , Mário A. T. Figueiredo

Learning causal relationships among a set of variables, as encoded by a directed acyclic graph, from observational data is complicated by the presence of unobserved confounders. Instrumental variables (IVs) are a popular remedy for this…

Methodology · Statistics 2025-04-17 Jing Zou , Wei Li , Wei Lin

This paper develops a general causal inference method for treatment effects models with noisily measured confounders. The key feature is that a large set of noisy measurements are linked with the underlying latent confounders through an…

Econometrics · Economics 2021-10-14 Yingjie Feng

Clinical machine learning applications are often plagued with confounders that can impact the generalizability and predictive performance of the learners. Confounding is especially problematic in remote digital health studies where the…

In the postgenome era many efforts have been dedicated to systematically elucidate the complex web of interacting genes and proteins. These efforts include experimental and computational methods. Microarray technology offers an opportunity…

Molecular Networks · Quantitative Biology 2009-08-04 L. Diambra

Causal models seek to unravel the cause-effect relationships among variables from observed data, as opposed to mere mappings among them, as traditional regression models do. This paper introduces a novel causal discovery algorithm designed…

Machine Learning · Computer Science 2024-10-03 Saeed Mohseni-Sehdeh , Walid Saad

Time series forecasting is a critical task in various domains, where accurate predictions can drive informed decision-making. Traditional forecasting methods often rely on current observations of variables to predict future outcomes,…

Machine Learning · Computer Science 2026-03-17 Wentao Gao , Xiaojing Du , Wenjun Yu , Xiongren Chen , Yifan Guo , Feiyu Yang

Many frameworks exist to infer cause and effect relations in complex nonlinear systems but a complete theory is lacking. A new framework is presented that is fully nonlinear, provides a complete information theoretic disentanglement of…

Methodology · Statistics 2022-01-12 Peter Jan van Leeuwen , Michael DeCaria , Nachiketa Chakaborty , Manuel Pulido

A common concern when trying to draw causal inferences from observational data is that the measured covariates are insufficiently rich to account for all sources of confounding. In practice, many of the covariates may only be proxies of the…

Methodology · Statistics 2023-08-31 Oliver Dukes , Ilya Shpitser , Eric J. Tchetgen Tchetgen

We consider learning the possible causal direction of two observed variables in the presence of latent confounding variables. Several existing methods have been shown to consistently estimate causal direction assuming linear or some type of…

Machine Learning · Statistics 2014-05-21 Shohei Shimizu , Kenneth Bollen

When a dynamical system can be modeled as a sequence of observations, Granger causality is a powerful approach for detecting predictive interactions between its variables. However, traditional Granger causal inference has limited utility in…

Machine Learning · Computer Science 2022-10-20 Rohit Singh , Alexander P. Wu , Bonnie Berger

We study the problem of experimental design for accurately identifying the causal graph structure of a simple structural causal model (SCM), where the underlying graph may include both cycles and bidirected edges induced by latent…

Machine Learning · Statistics 2025-09-03 Haijie Xu , Chen Zhang

We consider the problem of estimating a particular type of linear non-Gaussian model. Without resorting to the overcomplete Independent Component Analysis (ICA), we show that under some mild assumptions, the model is uniquely identified by…

Machine Learning · Computer Science 2021-03-29 Wei Chen , Kun Zhang , Ruichu Cai , Biwei Huang , Joseph Ramsey , Zhifeng Hao , Clark Glymour

Counterfactual learning has become promising for understanding and modeling causality in complex and dynamic systems. This paper presents a novel method for counterfactual learning in the context of multivariate time series analysis and…

Machine Learning · Computer Science 2026-03-03 Gianlucca Zuin , Adriano Veloso