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Assessing causal effects in the presence of unobserved confounding is a challenging problem. Existing studies leveraged proxy variables or multiple treatments to adjust for the confounding bias. In particular, the latter approach attributes…

Methodology · Statistics 2023-10-17 Yong Wu , Mingzhou Liu , Jing Yan , Yanwei Fu , Shouyan Wang , Yizhou Wang , Xinwei Sun

Predicting transcriptional responses to unseen genetic perturbations is essential for understanding gene regulation and prioritizing large-scale perturbation experiments. Existing approaches either rely on static, potentially incomplete…

Educational systems have traditionally been evaluated using cross-sectional studies, namely, examining a pretest, posttest, and single intervention. Although this is a popular approach, it does not model valuable information such as…

Applications · Statistics 2021-08-03 Manie Tadayon , Greg Pottie

We study the identification and estimation of long-term treatment effects under unobserved confounding by combining an experimental sample, where the long-term outcome is missing, with an observational sample, where the treatment assignment…

Econometrics · Economics 2026-01-27 Ting-Chih Hung , Yu-Chang Chen

Modern medical research demands specialized causal inference methods evaluating complex continuous-time dynamic treatment regimens using observational data. For instance, obtaining the causal effects of intravenous administration, a…

Methodology · Statistics 2026-04-02 Haiyan Zhu , Yingchun Zhou

Inferring causal effects of continuous-valued treatments from observational data is a crucial task promising to better inform policy- and decision-makers. A critical assumption needed to identify these effects is that all confounding…

Causal discovery from time-series data aims to capture both intra-slice (contemporaneous) and inter-slice (time-lagged) causality between variables within the temporal chain, which is crucial for various scientific disciplines. Compared to…

Machine Learning · Computer Science 2026-01-26 Rujia Shen , Boran Wang , Chao Zhao , Yi Guan , Jingchi Jiang

Accurately inferring Gene Regulatory Networks (GRNs) is a critical and challenging task in biology. GRNs model the activatory and inhibitory interactions between genes and are inherently causal in nature. To accurately identify GRNs,…

Single-cell perturbation modeling is fundamental for understanding and predicting cellular responses to genetic perturbations. However, existing approaches, from causal representation learning to foundation models, often struggle with an…

Machine Learning · Computer Science 2026-05-20 Wenkang Jiang , Yuhang Liu , Yichao Cai , Erdun Gao , Jiayi Dong , Ehsan Abbasnejad , Lina Yao , Javen Qinfeng Shi

Instruments can be used to identify causal effects in the presence of unobserved confounding, under the famous relevance and exogeneity (unconfoundedness and exclusion) assumptions. As exogeneity is difficult to justify and to some degree…

Econometrics · Economics 2023-08-29 Christian Tien

This paper studies inference on treatment effects in panel data settings with unobserved confounding. We model outcome variables through a factor model with random factors and loadings. Such factors and loadings may act as unobserved…

Econometrics · Economics 2023-12-05 Guido W. Imbens , Davide Viviano

We propose an approach to estimate the effect of multiple simultaneous interventions in the presence of hidden confounders. To overcome the problem of hidden confounding, we consider the setting where we have access to not only the…

Methodology · Statistics 2020-06-17 Sorawit Saengkyongam , Ricardo Silva

Estimating individual treatment effects (ITE) from observational data is a critical task across various domains. However, many existing works on ITE estimation overlook the influence of hidden confounders, which remain unobserved at the…

Machine Learning · Computer Science 2024-12-06 Binbin Hu , Zhicheng An , Zhengwei Wu , Ke Tu , Ziqi Liu , Zhiqiang Zhang , Jun Zhou , Yufei Feng , Jiawei Chen

Many questions in science center around the fundamental problem of understanding causal relationships. However, most constraint-based causal discovery algorithms, including the well-celebrated PC algorithm, often incur an exponential number…

Machine Learning · Computer Science 2024-06-05 Kirankumar Shiragur , Jiaqi Zhang , Caroline Uhler

We consider learning a causal ordering of variables in a linear non-Gaussian acyclic model called LiNGAM. Several existing methods have been shown to consistently estimate a causal ordering assuming that all the model assumptions are…

Machine Learning · Statistics 2013-07-30 Tatsuya Tashiro , Shohei Shimizu , Aapo Hyvarinen , Takashi Washio

Unmeasured confounders are a major source of bias in regression-based effect estimation and causal inference. In this paper, we advocate a new profiled transfer learning framework, ProTrans, to address confounding effects in the target…

Methodology · Statistics 2025-09-04 Ziyuan Chen , Yifan Jiang , Jingyuan Liu , Fang Yao

In causal inference, confounders are variables that influence both treatment decisions and outcomes. However, unlike as in randomized clinical trials, the treatment assignment mechanism in observational studies is not known, and it is thus…

Causal inference from observational data requires assumptions. These assumptions range from measuring confounders to identifying instruments. Traditionally, causal inference assumptions have focused on estimation of effects for a single…

Machine Learning · Statistics 2019-03-04 Rajesh Ranganath , Adler Perotte

Causal inference in spatial domains faces two intertwined challenges: (1) unmeasured spatial factors, such as weather, air pollution, or mobility, that confound treatment and outcome, and (2) interference from nearby treatments that violate…

Machine Learning · Computer Science 2025-10-13 Ayush Khot , Miruna Oprescu , Maresa Schröder , Ai Kagawa , Xihaier Luo

We consider a causal effect that is confounded by an unobserved variable, but with observed proxy variables of the confounder. We show that, with at least two independent proxy variables satisfying a certain rank condition, the causal…

Methodology · Statistics 2018-06-29 Wang Miao , Zhi Geng , Eric Tchetgen Tchetgen
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