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Quantitative photoacoustic tomography (qPAT) is an imaging technique aimed at estimating chromophore concentrations inside tissues from photoacoustic images, which are formed by combining optical information and ultrasonic propagation. The…

Computational Physics · Physics 2019-12-23 Hwan Goh , Timo Lahivaara , Tanja Tarvainen , Aki Pulkkinen , Owen Dillon , Ruanui Nicholson , Jari Kaipio

Efficient manipulation of light with sound in subwavelength-sized volumes is important for applications in photonics, phononics and biophysics, but remains elusive. We theoretically demonstrate the control of light with MHz-range ultrasound…

Optics · Physics 2017-03-22 Ivan S. Maksymov , Andrew D. Greentree

Photoacoustic microscopy (PAM) is a promising imaging modality because it is able to reveal optical absorption contrast in high resolution on the order of a micrometer. It can be applied in an endoscopic approach by implementing PAM into a…

Medical Physics · Physics 2019-11-22 Zhendong Guo , Zhanhong Ye , Weihao Shao , Lili Jing , Sung-Liang Chen

Conventional photoacoustic imaging may suffer from the limited view and bandwidth of ultrasound transducers. A deep learning approach is proposed to handle these problems and is demonstrated both in simulations and in experiments on a…

Image and Video Processing · Electrical Eng. & Systems 2020-11-19 Guillaume Godefroy , Bastien Arnal , Emmanuel Bossy

Image sensors are the backbone of many imaging technologies of great importance to modern sciences, being particularly relevant in biomedicine. An ideal image sensor should be usable through all the electromagnetic spectrum (large…

Medical Physics · Physics 2022-03-16 Juan Aguirre

Two-photon absorption (TPA) fluorescence of biomarkers has been decisive in advancing the fields of biosensing and deep-tissue in vivo imaging of live specimens. However, due to the extremely small TPA cross section and the quadratic…

Optics · Physics 2020-06-25 Tian Li , Fu Li , Charles Altuzarra , Anton Classen , Girish S. Agarwal

Molecules are emerging as new benchmark for metrology and fundamental physics research, driving the demand for spectroscopic techniques combining high sensitivity and resolution. Photoacoustic spectroscopy has proven to combine high…

Almost all known image reconstruction algorithms for photoacoustic and thermoacoustic tomography assume that the acoustic waves leave the region of interest after a finite time. This assumption is reasonable if the reflections from the…

Analysis of PDEs · Mathematics 2015-06-16 L. Kunyansky , B. Holman , B. T. Cox

Photoacoustic (PA) computed tomography (PACT) shows great potentials in various preclinical and clinical applications. A great number of measurements are the premise that obtains a high-quality image, which implies a low imaging rate or a…

Computer Vision and Pattern Recognition · Computer Science 2021-06-01 Hengrong Lan , Juze Zhang , Changchun Yang , Fei Gao

In an inhomogeneously illuminated photoacoustic image, important information like vascular geometry is not readily available when only the initial pressure is reconstructed. To obtain the desired information, algorithms for image…

Image and Video Processing · Electrical Eng. & Systems 2019-06-19 Yoeri E. Boink , Srirang Manohar , Christoph Brune

Photoacoustic tomography (PAT) has the potential to recover morphological and functional tissue properties with high spatial resolution. However, previous attempts to solve the optical inverse problem with supervised machine learning were…

Image and Video Processing · Electrical Eng. & Systems 2022-10-26 Melanie Schellenberg , Janek Gröhl , Kris K. Dreher , Jan-Hinrich Nölke , Niklas Holzwarth , Minu D. Tizabi , Alexander Seitel , Lena Maier-Hein

While in standard photoacoustic imaging the propagation of sound waves is modeled by the standard wave equation, our approach is based on a generalized wave equation with variable sound speed and material density, respectively. In this…

Analysis of PDEs · Mathematics 2018-04-18 Alexander Beigl , Peter Elbau , Kamran Sadiq , Otmar Scherzer

Integrated photonic sensors can provide large scale, flexible detection schemes. Photonic crystal slabs (PCS) offer a miniaturized platform for wideband, sensitive ultrasound detection by exploiting the photoelastic effect in water.…

Applied Physics · Physics 2021-08-17 Eric Y. Zhu , Maria Charles-Herrera , Cory Rewcastle , Raanan Gad , Li Qian , Ofer Levi

Purpose: Intraoperative ultrasound scanning is a demanding visuotactile task. It requires operators to simultaneously localise the ultrasound perspective and manually perform slight adjustments to the pose of the probe, making sure not to…

Image and Video Processing · Electrical Eng. & Systems 2025-07-09 Alistair Weld , Luke Dixon , Giulio Anichini , Michael Dyck , Alex Ranne , Sophie Camp , Stamatia Giannarou

We present a minimally-invasive endoscope based on a multimode fiber that combines photoacoustic and fluorescence sensing. From the measurement of a transmission matrix during a prior calibration step, a focused spot is produced and…

Optoacoustic image formation is conventionally based upon ultrasound time-of-flight readings from multiple detection positions. Herein, we exploit acoustic scattering to physically encode the position of optical absorbers in the acquired…

Biological Physics · Physics 2019-10-30 Xose Luis Dean-Ben , Ali Ozbek , Hernan Lopez-Schier , Daniel Razansky

Fluorescence microscopy has revolutionized biomedical research over the past three decades. Its high molecular specificity and unrivaled single molecule level sensitivity have enabled breakthroughs in a variety of research fields. For in…

Optics · Physics 2012-03-21 Meng Cui , Ke Si , Reto Fiolka

A crucial limitation of current high-resolution 3D photoacoustic tomography (PAT) devices that employ sequential scanning is their long acquisition time. In previous work, we demonstrated how to use compressed sensing techniques to improve…

Numerical Analysis · Mathematics 2020-09-07 Felix Lucka , Nam Huynh , Marta Betcke , Edward Zhang , Paul Beard , Ben Cox , Simon Arridge

Acoustic-Resolution Photoacoustic Microscopy (AR-PAM) is promising for subcutaneous vascular imaging, but its spatial resolution is constrained by the Point Spread Function (PSF). Traditional deconvolution methods like Richardson-Lucy and…

Computer Vision and Pattern Recognition · Computer Science 2024-10-29 Youshen Xiao , Sheng Liao , Xuanyang Tian , Fan Zhang , Xinlong Dong , Yunhui Jiang , Xiyu Chen , Ruixi Sun , Yuyao Zhang , Fei Gao

A low-cost adjustable illumination scheme for hand-held photoacoustic imaging probe is presented, manufactured and tested in this paper. Compared with traditional photoacoustic probe design, it has the following advantages: (1) Different…

Image and Video Processing · Electrical Eng. & Systems 2020-02-11 Yongjian Zhao , Shaohui Yu , Luyao Zhu , Hengrong Lan , Jinwei Li , Jianfeng Li , Fei Gao