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Imaging through opaque, highly scattering walls is a long sought after capability with potential applications in a variety of fields. The use of wavefront shaping to compensate for scattering has brought a renewed interest as a potential…

Optical imaging of blood flow yields critical functional insights into the circulatory system, but its clinical implementation has typically been limited to shallow depths (~1 millimeter) due to light scattering in biological tissue. Here,…

Medical Physics · Physics 2024-06-25 Yang Zhang , Joshua Olick-Gibson , Karteekeya Sastry , Lihong V. Wang

Biomedical applications requiring tissue diagnosis, activation, and treatment could be substantially leveraged by optical methods, owing to their unique feature set. However, their widespread application is severely limited by the strong…

Optics · Physics 2019-10-23 Maxim Cherkashin , Carsten Brenner , Georg Schmitz , Martin Hofmann

Photoacoustic imaging of interphalangeal peripheral joints is of interest in the context of using the synovial membrane as a surrogate marker of rheumatoid arthritis. Previous work has shown that ultrasound produced by absorption of light…

Medical Physics · Physics 2015-06-09 Samir Biswas , Peter van Es , Wiendelt Steenbergen , Srirang Manohar

Currently, diagnostic medicine uses a multitude of tools ranging from ionising radiation to histology analysis. With advances in piezoelectric crystal technology, high-frequency ultrasound imaging has developed to achieve comparatively high…

Medical Physics · Physics 2022-01-13 Akhil Kallepalli , James Halls , David B. James , Mark A. Richardson

Most reconstruction algorithms for photoacoustic imaging assume that the pressure field is measured by ultrasound sensors placed on a detection surface. However, such sensors do not measure pressure exactly due to their non-uniform…

Analysis of PDEs · Mathematics 2021-01-05 Sebastian Acosta

Advances in additive manufacturing have enabled the realisation of inexpensive, scalable, diffractive acoustic lenses that can be used to generate complex acoustic fields via phase and/or amplitude modulation. However, the design of these…

Sound · Computer Science 2023-05-08 Antonio Stanziola , Ben T. Cox , Bradley E. Treeby , Michael D. Brown

Photoacoustic computed tomography (PACT) is an emerging computed imaging modality that exploits optical contrast and ultrasonic detection principles to form images of the absorbed optical energy density within tissue. When the imaging…

Medical Physics · Physics 2016-11-15 Qiwei Sheng , Kun Wang , Thomas P. Matthews , Jun Xia , Liren Zhu , Lihong V. Wang , Mark A. Anastasio

Localization-based imaging has revolutionized fluorescence optical microscopy and has also enabled unprecedented ultrasound images of microvascular structures in deep tissues. Herein, we introduce a new concept of localization optoacoustic…

Optics · Physics 2017-07-10 Xose Luis Dean-Ben , Daniel Razansky

Controlling audible sound requires inherently broadband and subwavelength acoustic solutions, which are to date, crucially missing. This includes current noise absorption methods, such as porous materials or acoustic resonators, which are…

Applied Physics · Physics 2023-05-26 Stanislav Sergeev , Hervé Lissek , Romain Fleury

In photoacoustic computed tomography (PACT) with short-pulsed laser excitation, wideband acoustic signals are generated in biological tissues with frequencies related to the effective shapes and sizes of the optically absorbing targets.…

We developed a multifocus optical-resolution photoacoustic microscope (MPAM) with extended depth of field (DoF) by using a tunable acoustic gradient (TAG) lens and a pulse delay method. TAG lens is designed to control the divergence angle…

Optics · Physics 2020-09-09 Xianlin Song

Imaging of teeth is very important to doctors in the diagnosis and treatment of dental diseases. The main imaging modality currently used is Cone-Beam Computed Tomography (CBCT), which however suffers from ionizing radiation causing…

Medical Physics · Physics 2023-04-13 Yuting Shen , Yiyun Wang , Chengxiao Liu , Niansong Ye , Feng Gao , Lunguo Xia , Bing Fang , Fei Gao

The reconstruction task in photoacoustic tomography can vary a lot depending on measured targets, geometry, and especially the quantity we want to recover. Specifically, as the signal is generated due to the coupling of light and sound by…

Medical Physics · Physics 2023-11-28 Andreas Hauptmann , Tanja Tarvainen

Real-time monitoring of functional tissue parameters, such as local blood oxygenation, based on optical imaging could provide groundbreaking advances in the diagnosis and interventional therapy of various diseases. While photoacoustic (PA)…

Medical Physics · Physics 2018-08-15 Thomas Kirchner , Janek Gröhl , Lena Maier-Hein

We experimentally and numerically study the potential of photoacoustic-guiding for light focusing through scattering samples via wavefront-shaping and iterative optimization. We experimentally demonstrate that the focusing efficiency on an…

We demonstrate surface acoustic waves inside polystyrene microspheres of different sizes experimentally through photoacoustic microscopy and validate the experimental result with simulation. A novel method for sample preparation of a lifted…

Classical Physics · Physics 2022-03-22 Abhishek Ranjan , Anowarul Habib , Azeem Ahmad , Balpreet Singh Ahluwalia , Frank Melandsø

One primary technical challenge in photoacoustic microscopy (PAM) is the necessary compromise between spatial resolution and imaging speed. In this study, we propose a novel application of deep learning principles to reconstruct…

Image and Video Processing · Electrical Eng. & Systems 2020-06-02 Anthony DiSpirito , Daiwei Li , Tri Vu , Maomao Chen , Dong Zhang , Jianwen Luo , Roarke Horstmeyer , Junjie Yao

Photoacoustic sensing and imaging techniques have been studied widely to explore optical absorption contrast based on nanosecond laser illumination. In this paper, we report a long laser pulse induced dual photoacoustic (LDPA) nonlinear…

Lensless imaging is an elegant approach to high-resolution microscopy, which is rapidly gaining popularity in applications where imaging optics are problematic. However, current lensless imaging methods require objects to be placed within a…

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