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We present a mixed basis-set approach to obtain optical absorption spectra within a generalized Kohn-Sham time-dependent density functional theory framework. All occupied valence molecular orbitals (MOs) are expanded in a plane-wave (PW)…

Chemical Physics · Physics 2025-08-13 Kyle Chen , Barry Y. Li , Tucker Allen , Daniel Neuhauser

We investigate the electronic dynamics of a model organic photovoltaic (OPV) system consisting of polyphenylene vinylene (PPV) oligomers and a [6,6]-phenyl C61-butyric acid methylester (PCBM) blend using a mixed molecular mechanics/quantum…

Materials Science · Physics 2016-12-22 Allen C. Kelley , Eric R. Bittner

Optical imaging of the intensity, phase and polarization distributions of optical field is fundamental to numerous applications. Traditional methods rely on bulky optical components and require multiple measurements. Recently,…

Optics · Physics 2024-08-19 Yanjun Bao , Baojun Li

Lensless optical imaging eliminates the need for refractive optics, enabling compact and low-cost cameras with a large field-of-view, supporting point-of-care diagnostics and industrial monitoring. Practical deployments, however, remain…

Polarization light microscopes are powerful tools for probing molecular order and orientation in birefringent materials. While a multitude of polarization light microscopy techniques are often used to access steady-state properties of…

Quantum-optical coherence tomography (QOCT) is an optical sectioning modality based on the quantum interference of photon pairs, obtained from a spontaneous parametric downconversion (SPDC) source. The promise of QOCT derives from two…

Quantitative phase imaging (QPI) has been widely applied in characterizing cells and tissues. Spatial light interference microscopy (SLIM) is a highly sensitive QPI method, due to its partially coherent illumination and common path…

Image and Video Processing · Electrical Eng. & Systems 2024-06-12 Yuheng Jiao , Yuchen R. He , Mikhail E. Kandel , Xiaojun Liu , Wenlong Lu , Gabriel Popescu

Three-dimensional ultrasound localization microscopy (ULM) enables comprehensive visualization of the vasculature, thereby improving diagnostic reliability. Nevertheless, its clinical translation remains challenging, as the exponential…

Ordinary differential equations (ODE) are widely used for modeling in Systems Biology. As most commonly only some of the kinetic parameters are measurable or precisely known, parameter estimation techniques are applied to parametrize the…

Quantitative Methods · Quantitative Biology 2016-01-19 Christoph Zimmer , Frank T. Bergmann , Sven Sahle

Point multipole expansions are widely used to gain physical insight into complex distributions of charges and to reduce the cost of computing interactions between such distributions. However, practical applications that typically retain…

Classical Physics · Physics 2015-06-03 Charles Baker , Ramu Anandakrishnan , Alexey Onufriev

Studying the internal structure of complex samples with light is an important task, but a difficult challenge due to light scattering. While the complex optical distortions induced by multiple scattering can be effectively undone with the…

Optics · Physics 2019-10-04 Ori Katz , François Ramaz , Sylvain Gigan , Mathias Fink

The evaluation and monitoring of cells health in the human retina is crucial and follow time course of retinal diseases, detect lesions before irreversible visual loss and to evaluate treatment effects. Towards this goal, a major challenge…

Event vision sensors (neuromorphic cameras) output sparse, asynchronous ON/OFF events triggered by log-intensity threshold crossings, enabling microsecond-scale sensing with high dynamic range and low data bandwidth. As a nonlinear system,…

Computer Vision and Pattern Recognition · Computer Science 2026-01-21 Nimrod Kruger , Nicholas Owen Ralph , Gregory Cohen , Paul Hurley

Photomultiplication-type organic photodetectors (PM-OPDs) promise exceptional sensitivity for weak-light detection but typically suffer from a gain-bandwidth trade-off where high external quantum efficiency (EQE) incurs large dark current…

We report a novel microscopy platform, termed Multi-Aperture Fourier ptychographic microscopy (MA-FPM), capable of realizing gigapixel complex field images with large data acquisition bandwidths - in gigapixels per second. MA-FPM is a…

Optics · Physics 2020-10-14 Pavan Chandra Konda , Jonathan M. Taylor , Andrew R. Harvey

Sample-induced image-degradation remains an intricate wave-optical problem in light-sheet microscopy. Here we present biobeam, an open-source software package that enables to simulate operational light-sheet microscopes by combining data…

Biological Physics · Physics 2018-07-04 Martin Weigert , Eugene W. Myers , Moritz Kreysing

High-dimensional omics data contains intrinsic biomedical information that is crucial for personalised medicine. Nevertheless, it is challenging to capture them from the genome-wide data due to the large number of molecular features and…

Genomics · Quantitative Biology 2021-06-22 Xiaoyu Zhang , Yuting Xing , Kai Sun , Yike Guo

Optical molecular tomographic imaging is to reconstruct the concentration distribution of photon-molecular probes in a small animal from measured photon fluence rates. The localization and quantification of molecular probes is related to…

Biological Physics · Physics 2017-07-18 Wenxiang Cong , Xavier Intes , Ge Wang

Absorption imaging is a commonly adopted method to acquire, with high temporal resolution, spatial information on a partially transparent object. It relies on the interference between a probe beam and the coherent response of the object. In…

Multiphoton microscopy (MPM) has gained enormous popularity over the years for its capacity to provide high resolution images from deep within scattering samples1. However, MPM is generally based on single-point laser-focus scanning, which…

Optics · Physics 2018-12-14 Devin R. Beaulieu , Ian G. Davison , Thomas G. Bifano , Jerome Mertz
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