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Large language models (LLMs) are increasingly used for medical consultation and health information support. In this high-stakes setting, safety depends not only on medical knowledge, but also on how models respond when patient inputs are…

Computation and Language · Computer Science 2026-04-01 Yahan Li , Xinyi Jie , Wanjia Ruan , Xubei Zhang , Huaijie Zhu , Yicheng Gao , Chaohao Du , Ruishan Liu

One of the major barriers to using large language models (LLMs) in medicine is the perception they use uninterpretable methods to make clinical decisions that are inherently different from the cognitive processes of clinicians. In this…

Computation and Language · Computer Science 2023-08-15 Thomas Savage , Ashwin Nayak , Robert Gallo , Ekanath Rangan , Jonathan H Chen

Evaluating Large Language Models (LLMs) for mental health support is challenging due to the emotionally and cognitively complex nature of therapeutic dialogue. Existing benchmarks are limited in scale, reliability, often relying on…

Though Large Vision-Language Models (LVLMs) are being actively explored in medicine, their ability to conduct complex real-world telemedicine consultations combining accurate diagnosis with professional dialogue remains underexplored. This…

Human-Computer Interaction · Computer Science 2025-11-12 Ivan Sviridov , Amina Miftakhova , Artemiy Tereshchenko , Galina Zubkova , Pavel Blinov , Andrey Savchenko

Drug-drug interaction (DDI) prediction is critical for treatment safety. While large language models (LLMs) show promise in pharmaceutical tasks, their effectiveness in DDI prediction remains challenging. Inspired by the well-established…

Artificial Intelligence · Computer Science 2025-05-30 Guangyi Liu , Yongqi Zhang , Xunyuan Liu , Quanming Yao

The reliable evaluation of large language models (LLMs) in medical applications remains an open challenge, particularly in capturing the complexity of multi-turn doctor-patient interactions that unfold in real clinical environments.…

Artificial Intelligence · Computer Science 2025-10-15 Yuechun Yu , Han Ying , Haoan Jin , Wenjian Jiang , Dong Xian , Binghao Wang , Zhou Yang , Mengyue Wu

Large Language Models (LLMs) constitute a breakthrough state-of-the-art Artificial Intelligence (AI) technology which is rapidly evolving and promises to aid in medical diagnosis either by assisting doctors or by simulating a doctor's…

As opposed to evaluating computation and logic-based reasoning, current benchmarks for evaluating large language models (LLMs) in medicine are primarily focused on question-answering involving domain knowledge and descriptive reasoning.…

Effective clinical history taking is a foundational yet underexplored component of clinical reasoning. While large language models (LLMs) have shown promise on static benchmarks, they often fall short in dynamic, multi-turn diagnostic…

Computation and Language · Computer Science 2026-01-30 Yang Zhou , Zhenting Sheng , Mingrui Tan , Yuting Song , Jun Zhou , Yu Heng Kwan , Lian Leng Low , Yang Bai , Yong Liu

Large Language Models (LLMs) are increasingly deployed in critical applications requiring reliable reasoning, yet their internal reasoning processes remain difficult to evaluate systematically. Existing methods focus on final-answer…

Machine Learning · Computer Science 2026-02-03 Shaima Ahmad Freja , Ferhat Ozgur Catak , Betul Yurdem , Chunming Rong

While modern dialogue systems heavily rely on large language models (LLMs), their implementation often goes beyond pure LLM interaction. Developers integrate multiple LLMs, external tools, and databases. Therefore, assessment of the…

Artificial Intelligence · Computer Science 2025-07-23 Roman Mayr , Michel Schimpf , Thomas Bohné

The adoption of large language models (LLMs) in healthcare has attracted significant research interest. However, their performance in healthcare remains under-investigated and potentially limited, due to i) they lack rich domain-specific…

Artificial Intelligence · Computer Science 2024-05-21 Zishan Gu , Fenglin Liu , Changchang Yin , Ping Zhang

Research on dialogue constructiveness assessment focuses on (i) analysing conversational factors that influence individuals to take specific actions, win debates, change their perspectives or broaden their open-mindedness and (ii)…

Computation and Language · Computer Science 2024-10-03 Lexin Zhou , Youmna Farag , Andreas Vlachos

Mental health forums offer valuable insights into psychological issues, stressors, and potential solutions. We propose MHINDR, a large language model (LLM) based framework integrated with DSM-5 criteria to analyze user-generated text,…

Social and Information Networks · Computer Science 2025-10-01 Vaishali Agarwal , Sachin Thukral , Arnab Chatterjee

Recent advances in large language models (LLMs) have demonstrated impressive reasoning capacities that mirror human-like thinking. However, whether LLMs possess genuine fluid intelligence (i.e., the ability to reason abstractly and…

Artificial Intelligence · Computer Science 2025-09-30 Yue Yang , MingKang Chen , Qihua Liu , Mengkang Hu , Qiguang Chen , Gengrui Zhang , Shuyue Hu , Guangtao Zhai , Yu Qiao , Yu Wang , Wenqi Shao , Ping Luo

Medical problem-solving demands expert knowledge and intricate reasoning. Recent studies of large language models (LLMs) attempt to ease this complexity by introducing external knowledge verification through retrieval-augmented generation…

Computation and Language · Computer Science 2026-01-19 Yue Huang , Yanyuan Chen , Dexuan Xu , Chenzhuo Zhao , Weihua Yue , Yu Huang

Standard single-turn, static benchmarks fall short in evaluating the nuanced capabilities of Large Language Models (LLMs) on complex tasks such as software engineering. In this work, we propose a novel interactive evaluation framework that…

Artificial Intelligence · Computer Science 2025-08-27 Dimitrios Rontogiannis , Maxime Peyrard , Nicolas Baldwin , Martin Josifoski , Robert West , Dimitrios Gunopulos

The integration of Large Language Models (LLMs) into clinical decision support is critically obstructed by their opaque and often unreliable reasoning. In the high-stakes domain of healthcare, correct answers alone are insufficient;…

Artificial Intelligence · Computer Science 2026-04-21 Chen Zhan , Xiaoyu Tan , Gengchen Ma , Yu-Jie Xiong , Xiaoyan Jiang , Xihe Qiu

Accurate clinical diagnosis requires extensive domain knowledge and complex clinical reasoning capabilities. Although large language models (LLMs) hold great potential for clinical reasoning, their high computational and memory requirements…

Computers and Society · Computer Science 2026-05-12 Xinchun Su , Chunxu Luo , Lipeng Ma , Yixuan Li , Weidong Yang

There are currently two main paradigms for evaluating large language models (LLMs), reference-based evaluation and preference-based evaluation. The first, carried over from the evaluation of machine learning models in general, relies on…

Computation and Language · Computer Science 2026-02-27 David Schlangen , Sherzod Hakimov , Chalamalasetti Kranti , Jonathan Jordan , Philipp Sadler
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