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Accurate symptom-to-disease classification and clinically grounded treatment recommendations remain challenging, particularly in heterogeneous patient settings with high diagnostic risk. Existing large language model (LLM)-based systems…

Recent advancements in large language models (LLMs) have shown promise in generating psychotherapeutic dialogues, particularly in the context of motivational interviewing (MI). However, the inherent lack of transparency in LLM outputs…

Computation and Language · Computer Science 2024-12-18 Xin Sun , Xiao Tang , Abdallah El Ali , Zhuying Li , Pengjie Ren , Jan de Wit , Jiahuan Pei , Jos A. Bosch

General Multimodal Large Language Models (MLLMs) often underperform in capturing domain-specific nuances in medical diagnosis, trailing behind fully supervised baselines. Although fine-tuning provides a remedy, the high costs of expert…

Computer Vision and Pattern Recognition · Computer Science 2026-03-31 Wenkai Zhao , Zipei Wang , Mengjie Fang , Di Dong , Jie Tian , Lingwei Zhang

Clinical decision-making is inherently complex, often influenced by cognitive biases, incomplete information, and case ambiguity. Large Language Models (LLMs) have shown promise as tools for supporting clinical decision-making, yet their…

Machine Learning · Computer Science 2025-07-10 Burcu Sayin , Ipek Baris Schlicht , Ngoc Vo Hong , Sara Allievi , Jacopo Staiano , Pasquale Minervini , Andrea Passerini

Objectives: While Large Language Models (LLMs) have been widely used to assist clinicians and support patients, no existing work has explored dialogue systems for standard diagnostic interviews and assessments. This study aims to bridge the…

Computation and Language · Computer Science 2025-05-01 Sichang Tu , Abigail Powers , Stephen Doogan , Jinho D. Choi

The rapid evolution of large language models (LLMs) has transformed conversational agents, enabling complex human-machine interactions. However, evaluation frameworks often focus on single tasks, failing to capture the dynamic nature of…

Computation and Language · Computer Science 2025-02-10 Pietro Alessandro Aluffi , Patrick Zietkiewicz , Marya Bazzi , Matt Arderne , Vladimirs Murevics

As large language models (LLMs) advance in conversational and reasoning capabilities, their practical application in healthcare has become a critical research focus. However, there is a notable gap between the performance of medical LLMs on…

Clinical decision support requires not only correct answers but also clinically valid reasoning. We propose Differential Reasoning Learning (DRL), a framework that improves clinical agents by learning from reasoning discrepancies. From…

Artificial Intelligence · Computer Science 2026-02-11 Jinsong Liu , Yuhang Jiang , Ramayya Krishnan , Rema Padman , Yiye Zhang , Jiang Bian

The use of large language models in medical dialogue generation has garnered significant attention, with a focus on improving response quality and fluency. While previous studies have made progress in optimizing model performance for…

Computation and Language · Computer Science 2024-08-06 Chengfeng Dou , Zhi Jin , Wenpin Jiao , Haiyan Zhao , Yongqiang Zhao , Zhenwei Tao

LLMs are popular among clinicians for decision-support because of simple text-based interaction. However, their impact on clinicians' performance is ambiguous. Not knowing how clinicians use this new technology and how they compare it to…

Human-Computer Interaction · Computer Science 2026-02-02 Behnam Rahdari , Sameer Shaikh , Jonathan H Chen , Tobias Gerstenberg , Shriti Raj

While cognitive diagnosis (CD) effectively assesses students' knowledge mastery from structured test data, applying it to real-world teacher-student dialogues presents two fundamental challenges. Traditional CD models lack a suitable…

Computation and Language · Computer Science 2025-10-15 Rui Jia , Yuang Wei , Ruijia Li , Yuan-Hao Jiang , Xinyu Xie , Yaomin Shen , Min Zhang , Bo Jiang

Recent advances in large language models (LLMs) have shown promising results in medical diagnosis, with some studies indicating superior performance compared to human physicians in specific scenarios. However, the diagnostic capabilities of…

Artificial Intelligence · Computer Science 2025-03-24 Zhoujian Sun , Ziyi Liu , Cheng Luo , Jiebin Chu , Zhengxing Huang

Large language models (LLMs) hold significant potential for mental health support, capable of generating empathetic responses and simulating therapeutic conversations. However, existing LLM-based approaches often lack the clinical grounding…

Computation and Language · Computer Science 2025-11-04 He Hu , Yucheng Zhou , Juzheng Si , Qianning Wang , Hengheng Zhang , Fuji Ren , Fei Ma , Laizhong Cui , Qi Tian

Clinical decision support systems require models that are not only highly accurate but also equitable and sensitive to the implications of missed diagnoses. In this study, we introduce a knowledge-guided in-context learning (ICL) framework…

Machine Learning · Computer Science 2025-07-28 Fatemeh Nazary , Yashar Deldjoo , Tommaso Di Noia , Eugenio di Sciascio

We present Clinical Camel, an open large language model (LLM) explicitly tailored for clinical research. Fine-tuned from LLaMA-2 using QLoRA, Clinical Camel achieves state-of-the-art performance across medical benchmarks among openly…

Computation and Language · Computer Science 2023-08-21 Augustin Toma , Patrick R. Lawler , Jimmy Ba , Rahul G. Krishnan , Barry B. Rubin , Bo Wang

We propose DISC-MedLLM, a comprehensive solution that leverages Large Language Models (LLMs) to provide accurate and truthful medical response in end-to-end conversational healthcare services. To construct high-quality Supervised…

Computation and Language · Computer Science 2023-08-29 Zhijie Bao , Wei Chen , Shengze Xiao , Kuang Ren , Jiaao Wu , Cheng Zhong , Jiajie Peng , Xuanjing Huang , Zhongyu Wei

In clinical operations, teamwork can be the crucial factor that determines the final outcome. Prior studies have shown that sufficient collaboration is the key factor that determines the outcome of an operation. To understand how the team…

Computation and Language · Computer Science 2025-06-17 Naihao Deng , Kapotaksha Das , Rada Mihalcea , Vitaliy Popov , Mohamed Abouelenien

The advent of Large Language Models (LLMs) has ushered in a new era for design science in Information Systems, demanding a paradigm shift in tailoring LLMs design for business contexts. We propose and test a novel framework to customize…

Computers and Society · Computer Science 2024-05-15 Wen Wang , Zhenyue Zhao , Tianshu Sun

Large language models (LLMs) enabled dialogue systems have become one of the central modes in human-machine interaction, which bring about vast amounts of conversation logs and increasing demand for dialogue generation. The dialogue's…

Computation and Language · Computer Science 2025-06-02 Minzheng Wang , Xinghua Zhang , Kun Chen , Nan Xu , Haiyang Yu , Fei Huang , Wenji Mao , Yongbin Li

There is growing interest in using machine learning (ML) to support clinical diagnosis, but most approaches rely on static, fully observed datasets and fail to reflect the sequential, resource-aware reasoning clinicians use in practice.…

Artificial Intelligence · Computer Science 2025-11-18 Silas Ruhrberg Estévez , Nicolás Astorga , Mihaela van der Schaar
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