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Background: Psychedelic drugs facilitate profound changes in consciousness and have potential to provide insights into the nature of human mental processes and their relation to brain physiology. Yet published scientific literature reflects…

Quantitative Methods · Quantitative Biology 2012-06-05 Jeremy R. Coyle , David E. Presti , Matthew J. Baggott

With the volatile and complex nature of financial data influenced by external factors, forecasting the stock market is challenging. Traditional models such as ARIMA and GARCH perform well with linear data but struggle with non-linear…

Machine Learning · Computer Science 2025-01-30 Prashant Pilla , Raji Mekonen

Background: Stroke is second-leading cause of disability and death among adults. Approximately 17 million people suffer from a stroke annually, with about 85% being ischemic strokes. Predicting mortality of ischemic stroke patients in…

Machine Learning · Computer Science 2024-09-04 Armin Abdollahi , Negin Ashrafi , Maryam Pishgar

Importance: Emergency department (ED) returns for mental health conditions pose a major healthcare burden, with 24-27% of patients returning within 30 days. Traditional machine learning models for predicting these returns often lack…

Accurate prediction of Drug-Target Affinity (DTA) is of vital importance in early-stage drug discovery, facilitating the identification of drugs that can effectively interact with specific targets and regulate their activities. While wet…

Biomolecules · Quantitative Biology 2023-10-18 Qizhi Pei , Lijun Wu , Jinhua Zhu , Yingce Xia , Shufang Xie , Tao Qin , Haiguang Liu , Tie-Yan Liu , Rui Yan

SARS-COV-19 is the most prominent issue which many countries face today. The frequent changes in infections, recovered and deaths represents the dynamic nature of this pandemic. It is very crucial to predict the spreading rate of this virus…

Populations and Evolution · Quantitative Biology 2023-02-01 Sadhana Tiwari , Ritesh Chandra , Sonali Agarwal

Predictive models for clinical outcomes that are accurate on average in a patient population may underperform drastically for some subpopulations, potentially introducing or reinforcing inequities in care access and quality. Model training…

Machine Learning · Statistics 2022-02-03 Stephen R. Pfohl , Haoran Zhang , Yizhe Xu , Agata Foryciarz , Marzyeh Ghassemi , Nigam H. Shah

Multi-state models provide an extension of the usual survival/event-history analysis setting. In the medical domain, multi-state models give the possibility of further investigating intermediate events such as relapse and remission. In this…

Methodology · Statistics 2021-06-24 D. Manevski , H. Putter , M. Pohar Perme , E. F. Bonneville , J. Schetelig , L. C. de Wreede

Drug-target interaction (DTI) prediction plays a crucial role in drug discovery, and deep learning approaches have achieved state-of-the-art performance in this field. We introduce an ensemble of deep learning models (EnsembleDLM) for DTI…

Biomolecules · Quantitative Biology 2022-01-19 Po-Yu Kao , Shu-Min Kao , Nan-Lan Huang , Yen-Chu Lin

Survival analysis is essential for studying time-to-event outcomes and providing a dynamic understanding of the probability of an event occurring over time. Various survival analysis techniques, from traditional statistical models to…

Machine Learning · Computer Science 2024-03-13 Ziwen Wang , Jin Wee Lee , Tanujit Chakraborty , Yilin Ning , Mingxuan Liu , Feng Xie , Marcus Eng Hock Ong , Nan Liu

The time it takes for a classifier to make an accurate prediction can be crucial in many behaviour recognition problems. For example, an autonomous vehicle should detect hazardous pedestrian behaviour early enough for it to take appropriate…

Machine Learning · Computer Science 2020-02-27 Joel Janek Dabrowski , Johan Pieter de Villiers , Ashfaqur Rahman , Conrad Beyers

Accurate and reliable forecasting models are critical for guiding public health responses and policy decisions during pandemics such as COVID-19. Retrospective evaluation of model performance is essential for improving epidemic forecasting…

Epidemic forecasting faces a fundamental challenge: human behavior dynamically responds to disease spread, creating feedback loops that induce distribution shifts at policy intervention points. This renders data-driven models unreliable…

Machine Learning · Computer Science 2026-05-27 Haochun Wang , Sendong Zhao , Jingbo Wang , Yanrui Du , Bing Qin , Ting Liu

Undoubtedly, several countries worldwide endure to experience a continuous increase in life expectancy, extending the challenges of life actuaries and demographers in forecasting mortality. Although several stochastic mortality models have…

Applications · Statistics 2021-03-22 Mario Marino , Susanna Levantesi , Andrea Nigri

Forecasting the effect of COVID-19 is essential to design policies that may prepare us to handle the pandemic. Many methods have already been proposed, particularly, to forecast reported cases and deaths at country-level and state-level.…

Populations and Evolution · Quantitative Biology 2020-07-14 Ajitesh Srivastava , Tianjian Xu , Viktor K. Prasanna

Childhood obesity is a major public health challenge. Early prediction and identification of the children at a high risk of developing childhood obesity may help in engaging earlier and more effective interventions to prevent and manage…

Applications · Statistics 2022-05-03 Mehak Gupta , Thao-Ly T. Phan , Timothy Bunnell , Rahmatollah Beheshti

We present efforts in the fields of machine learning and time series forecasting to accurately predict counts of future suspected opioid overdoses recorded by Emergency Medical Services (EMS) in the state of Kentucky. Forecasts help…

In power grids, short-term load forecasting (STLF) is crucial as it contributes to the optimization of their reliability, emissions, and costs, while it enables the participation of energy companies in the energy market. STLF is a…

The current outbreak of COVID-19 has called renewed attention to the need for sound statistical analysis for monitoring mortality patterns and trends over time. Excess mortality has been suggested as the most appropriate indicator to…

Applications · Statistics 2020-10-13 Patrizio Vanella , Ugofilippo Basellini , Berit Lange

Prediction of couriers' delivery timely rates in advance is essential to the logistics industry, enabling companies to take preemptive measures to ensure the normal operation of delivery services. This becomes even more critical during…

Machine Learning · Computer Science 2025-05-02 Jinhui Yi , Huan Yan , Haotian Wang , Jian Yuan , Yong Li