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To develop an automated workflow for rectal cancer three-dimensional conformal radiotherapy treatment planning that combines deep-learning(DL) aperture predictions and forward-planning algorithms. We designed an algorithm to automate the…

Medical imaging has revolutionized diagnosis, yet unnecessary procedures are rising, exposing patients to radiation and stress, limiting equitable access, and straining healthcare systems. The American College of Radiology Appropriateness…

Quantitative Methods · Quantitative Biology 2025-10-08 Anni Tziakouri , Filippo Menolascina

Cataract surgery remains one of the most widely performed and effective procedures for vision restoration. Effective surgical planning requires integrating diverse clinical examinations for patient assessment, intraocular lens (IOL)…

Multiagent Systems · Computer Science 2025-08-28 Yang Meng , Zewen Pan , Yandi Lu , Ruobing Huang , Yanfeng Liao , Jiarui Yang

As LLM agents transition to autonomous digital coworkers, maintaining deterministic goal-directedness in non-linear multi-turn conversations emerged as an architectural bottleneck. We identify and formalize a systemic failure mode termed…

Artificial Intelligence · Computer Science 2026-04-28 Dahlia Shehata , Ming Li

We present PULSE, a medical reasoning agent that combines a domain-tuned large language model with scientific literature retrieval to support diagnostic decision-making in complex real-world cases. To evaluate its capabilities, we curated a…

Computation and Language · Computer Science 2026-03-19 Zhongzhen Huang , Yan Ling , Hong Chen , Ye Feng , Li Wu , Linjie Mu , Shaoting Zhang , Xiaofan Zhang , Kun Qian , Xiaomu Li

Stereotactic body radiotherapy (SBRT) is characterized by delivering a high amount of dose in a short period of time. In SBRT the dose is delivered using open fields (e.g., beam's-eye-view) known as "apertures". Mathematical methods can be…

Medical Physics · Physics 2015-06-15 Hamed Yarmand , David Craft

Complex dialog systems often use retrieved evidence to facilitate factual responses. Such RAG (Retrieval Augmented Generation) systems retrieve from massive heterogeneous data stores that are usually architected as multiple indexes or APIs…

Information Retrieval · Computer Science 2024-08-01 Ashutosh Joshi , Sheikh Muhammad Sarwar , Samarth Varshney , Sreyashi Nag , Shrivats Agrawal , Juhi Naik

We introduce Plan*RAG, a novel framework that enables structured multi-hop reasoning in retrieval-augmented generation (RAG) through test-time reasoning plan generation. While existing approaches such as ReAct maintain reasoning chains…

Computation and Language · Computer Science 2025-02-05 Prakhar Verma , Sukruta Prakash Midigeshi , Gaurav Sinha , Arno Solin , Nagarajan Natarajan , Amit Sharma

What does it mean to plan? Current agentic systems, whether scaffolded workflows or end-to-end policies, rely on reactive decision-making: selecting the next action via a fixed procedure with at most undifferentiated adaptive computation…

Artificial Intelligence · Computer Science 2026-05-22 Mingkai Deng , Jinyu Hou , Zhiting Hu , Eric Xing

Rare diseases represent the long tail of medical imaging, where AI models often fail due to the scarcity of representative training data. In clinical workflows, radiologists frequently consult case reports and literature when confronted…

Computation and Language · Computer Science 2025-11-10 Ha Young Kim , Jun Li , Ana Beatriz Solana , Carolin M. Pirkl , Benedikt Wiestler , Julia A. Schnabel , Cosmin I. Bercea

The emergence of large language models has enabled sophisticated multi-agent systems, yet coordinating their reasoning capabilities through prompt engineering remains challenging. We present a theoretically-grounded framework for dynamic…

Multiagent Systems · Computer Science 2025-10-02 Hassen Dhrif

PET theranostics is transforming precision oncology, yet treatment response varies substantially; many patients receiving 177Lu-PSMA radioligand therapy (RLT) for metastatic castration-resistant prostate cancer (mCRPC) fail to respond,…

Multiple myeloma is managed through sequential lines of therapy over years to decades, with each decision depending on cumulative disease history distributed across dozens to hundreds of heterogeneous clinical documents. Whether LLM-based…

Large language models are unable to continuously adapt and learn from new data during reasoning at inference time. To address this limitation, we propose that complex reasoning tasks be decomposed into atomic subtasks and introduce SAGE, a…

Computation and Language · Computer Science 2025-09-09 Jiacheng Wei , Faguo Wu , Xiao Zhang

Despite recent success in applying large language models (LLMs) to electronic health records (EHR), most systems focus primarily on assessment rather than treatment planning. We identify three critical limitations in current approaches:…

Artificial intelligence-based radiation therapy (RT) planning has the potential to reduce planning time and inter-planner variability, improving efficiency and consistency in clinical workflows. Most existing automated approaches rely on…

Agentic retrieval-augmented reasoning pipelines are increasingly used to structure how large language models (LLMs) incorporate external evidence in clinical decision support. These systems iteratively retrieve curated domain knowledge and…

Robotic-assisted surgery (RAS) is central to modern surgery, driving the need for intelligent systems with accurate scene understanding. Most existing surgical AI methods rely on isolated, task-specific models, leading to fragmented…

Artificial Intelligence · Computer Science 2026-02-19 Chang Han Low , Ziyue Wang , Tianyi Zhang , Zhu Zhuo , Zhitao Zeng , Evangelos B. Mazomenos , Yueming Jin

The integration of Large Language Models (LLMs) into healthcare is constrained by knowledge limitations, hallucinations, and a disconnect from Evidence-Based Medicine (EBM). While Retrieval-Augmented Generation (RAG) offers a solution,…

Computation and Language · Computer Science 2026-02-03 Qiaoyu Zheng , Yuze Sun , Chaoyi Wu , Weike Zhao , Pengcheng Qiu , Yongguo Yu , Kun Sun , Jian Zhang , Yanfeng Wang , Ya Zhang , Weidi Xie

Retrieval-Augmented Generation (RAG) is widely employed to mitigate risks such as hallucinations and knowledge obsolescence in medical question answering, yet its predominantly single-round, static retrieval paradigm misaligns with the…

Computation and Language · Computer Science 2026-05-19 Yongfeng Huang , Ruiying Chen , James Cheng