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Based on a recently proposed non-equilibrium mechanism for spatial pattern formation [cond-mat/0312366] we study how morphogenesis can be controlled by locally coupled discrete dynamical networks, similar to gene regulation networks of…

Molecular Networks · Quantitative Biology 2007-05-23 Thimo Rohlf , Stefan Bornholdt

Given the stochastic nature of gene expression, genetically identical cells exposed to the same environmental inputs will produce different outputs. This heterogeneity has been hypothesized to have consequences for how cells are able to…

Molecular Networks · Quantitative Biology 2020-08-19 Manuel Razo-Mejia , Sarah Marzen , Griffin Chure , Rachel Taubman , Muir Morrison , Rob Phillips

Living cells deploy many resources to sense their environments, including receptors, downstream signaling molecules, time and fuel. However, it is not known which resources fundamentally limit the precision of sensing, like weak links in a…

Molecular Networks · Quantitative Biology 2014-01-31 Christopher C. Govern , Pieter Rein ten Wolde

The fundamental processes of biological development are governed by multiple signaling molecules that create non-uniform concentration profiles known as morphogen gradients. It is widely believed that the establishment of morphogen…

Biological Physics · Physics 2015-06-18 Hamid Teimouri , Anatoly B. Kolomeisky

Parallel recordings of neural spike counts have revealed the existence of context-dependent noise correlations in neural populations. Theories of population coding have also shown that such correlations can impact the information encoded by…

Machine Learning · Computer Science 2025-07-30 Sacha Sokoloski , Ruben Coen-Cagli

Transfer learning aims to improve performance on a target task by leveraging information from related source tasks. We propose a nonparametric regression transfer learning framework that explicitly models heterogeneity in the source-target…

Statistics Theory · Mathematics 2026-03-19 Hélène Halconruy , Benjamin Bobbia , Paul Lejamtel

Non-stationary sequences arise naturally in control, forecasting, and decision-making. The data-generating process shifts at unknown times, and models must detect the change, discard or downweight obsolete evidence, and adapt to new…

Machine Learning · Computer Science 2026-04-21 Carson Dudley , Yutong Bi , Xiaofeng Liu , Samet Oymak

We introduce a simple time-triggered protocol to achieve communication-efficient non-Bayesian learning over a network. Specifically, we consider a scenario where a group of agents interact over a graph with the aim of discerning the true…

Systems and Control · Electrical Eng. & Systems 2019-09-05 Aritra Mitra , John A. Richards , Shreyas Sundaram

Biological neurons and their in-silico emulations for neuromorphic artificial intelligence (AI) use extraordinarily energy-efficient mechanisms, such as spike-based communication and local synaptic plasticity. It remains unclear whether…

Neural and Evolutionary Computing · Computer Science 2021-06-17 Timoleon Moraitis , Abu Sebastian , Evangelos Eleftheriou

Atomic structures and adatom geometries of surfaces encode information about the thermodynamics and kinetics of the processes that lead to their formation, and which can be captured by a generative physical model. Here we develop a workflow…

During development, spatio-temporal patterns ranging from checkerboard to engulfing occur with precise proportions of the respective cell fates. Key developmental regulators are intracellular transcriptional interactions and intercellular…

Biological Physics · Physics 2022-11-15 Simon Schardt , Sabine C. Fischer

Machine learning models can represent climate processes that are nonlocal in horizontal space, height, and time, often by combining information across these dimensions in highly nonlinear ways. While this can improve predictive skill, it…

Machine Learning · Computer Science 2026-05-14 Savannah L. Ferretti , Jerry Lin , Sara Shamekh , Jane W. Baldwin , Michael S. Pritchard , Tom Beucler

Spatial models for occupancy data are used to estimate and map the true presence of a species, which may depend on biotic and abiotic factors as well as spatial autocorrelation. Traditionally researchers have accounted for spatial…

Applications · Statistics 2021-05-05 Narmadha M. Mohankumar , Trevor J. Hefley

Biological and artificial systems encode information through several complex nonlinear operations, making their exact study a formidable challenge. These internal mechanisms often take place across multiple timescales and process external…

Statistical Mechanics · Physics 2024-11-19 Giorgio Nicoletti , Daniel M. Busiello

Bayesian Optimization (BO) is a key methodology for accelerating molecular discovery by estimating the mapping from molecules to their properties while seeking the optimal candidate. Typically, BO iteratively updates a probabilistic…

Machine Learning · Computer Science 2025-12-17 Qi Chen , Fabio Ramos , Alán Aspuru-Guzik , Florian Shkurti

Model-based approaches bear great promise for decision making of agents interacting with the physical world. In the context of spatial environments, different types of problems such as localisation, mapping, navigation or autonomous…

Machine Learning · Statistics 2019-06-21 Atanas Mirchev , Baris Kayalibay , Maximilian Soelch , Patrick van der Smagt , Justin Bayer

Biological and artificial neural systems are composed of many local processors, and their capabilities depend upon the transfer function that relates each local processor's outputs to its inputs. This paper uses a recent advance in the…

Information Theory · Computer Science 2018-03-16 Jim W. Kay , William A. Phillips

Understanding how neural systems efficiently process information through distributed representations is a fundamental challenge at the interface of neuroscience and machine learning. Recent approaches analyze the statistical and geometrical…

Neurons and Cognition · Quantitative Biology 2025-04-01 Francesca Mignacco , Chi-Ning Chou , SueYeon Chung

To thrive in dynamic environments, animals must be capable of rapidly and flexibly adapting behavioral responses to a changing context and internal state. Examples of behavioral flexibility include faster stimulus responses when attentive…

Neurons and Cognition · Quantitative Biology 2021-01-27 David Wyrick , Luca Mazzucato

Neurons in the nervous system convey information to higher brain regions by the generation of spike trains. An important question in the field of computational neuroscience is how these sensory neurons encode environmental information in a…

Neurons and Cognition · Quantitative Biology 2013-09-13 Alex Susemihl , Ron Meir , Manfred Opper
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