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The modeling of bio-molecular system across molecular scales remains a central challenge in scientific research. Large language models (LLMs) are increasingly applied to bio-molecular discovery, yet systematic evaluation across multi-scale…

Machine Learning · Computer Science 2026-04-07 Yaxin Xu , Yue Zhou , Tianyu Zhao , Fengwei An , Zhixiang Ren

The use of Large Language Models (LLMs) in mathematical reasoning has become a cornerstone of related research, demonstrating the intelligence of these models and enabling potential practical applications through their advanced performance,…

Computation and Language · Computer Science 2024-12-20 Kathrin Seßler , Yao Rong , Emek Gözlüklü , Enkelejda Kasneci

Large language models (LLMs) are increasingly used in medical fields. In mental health support, the early identification of linguistic markers associated with mental health conditions can provide valuable support to mental health…

Computation and Language · Computer Science 2026-02-03 Konstantinos Skianis , A. Seza Doğruöz , John Pavlopoulos

Accurate prediction of treatment outcomes in lung cancer remains challenging due to the sparsity, heterogeneity, and contextual overload of real-world electronic health data. Traditional models often fail to capture semantic information…

This study investigates the adoption of open-access, locally deployable causal large language models (LLMs) for travel mode choice prediction and introduces LiTransMC, the first fine-tuned causal LLM developed for this task. We…

Computation and Language · Computer Science 2025-10-08 Tareq Alsaleh , Bilal Farooq

There is a significant gap between patient needs and available mental health support today. In this paper, we aim to thoroughly examine the potential of using Large Language Models (LLMs) to assist professional psychotherapy. To this end,…

Computation and Language · Computer Science 2025-01-28 Mian Zhang , Xianjun Yang , Xinlu Zhang , Travis Labrum , Jamie C. Chiu , Shaun M. Eack , Fei Fang , William Yang Wang , Zhiyu Zoey Chen

Large language models (LLMs) have shown amazing capabilities in knowledge memorization and the present. However, when it comes to domain-specific knowledge and downstream tasks like medical, general LLMs are often unable to give precise…

Computation and Language · Computer Science 2024-06-06 Maojun Sun

Clinical reasoning agents based on large language models (LLMs) aim to automate tasks such as intensive care unit (ICU) monitoring and patient state tracking from electronic health records (EHRs). Existing systems typically rely on manually…

Artificial Intelligence · Computer Science 2026-05-12 Timothy Ossowski , Xinchi Liu , Danyal Maqbool , Vaibhav Dhanuka , Sheng Zhang , Hoifung Poon , Majid Afshar , Tyler Bradshaw , Junjie Hu

This study evaluates the performance of large language models (LLMs) and the HINT model in predicting clinical trial outcomes, focusing on metrics including Balanced Accuracy, Matthews Correlation Coefficient (MCC), Recall, and Specificity.…

Machine Learning · Computer Science 2025-03-19 Shuyi Jin , Lu Chen , Hongru Ding , Meijie Wang , Lun Yu

Recent advancements in reasoning-enhanced large language models (LLMs), such as DeepSeek-R1 and OpenAI-o3, have demonstrated significant progress. However, their application in professional medical contexts remains underexplored,…

Computation and Language · Computer Science 2025-03-11 Pengcheng Qiu , Chaoyi Wu , Shuyu Liu , Weike Zhao , Zhuoxia Chen , Hongfei Gu , Chuanjin Peng , Ya Zhang , Yanfeng Wang , Weidi Xie

In the U.S. inpatient payment system, the Diagnosis-Related Group (DRG) is pivotal, but its assignment process is inefficient. The study introduces DRG-LLaMA, an advanced large language model (LLM) fine-tuned on clinical notes to enhance…

Artificial Intelligence · Computer Science 2023-10-02 Hanyin Wang , Chufan Gao , Christopher Dantona , Bryan Hull , Jimeng Sun

Smartphone sensing offers an unobtrusive and scalable way to track daily behaviors linked to mental health, capturing changes in sleep, mobility, and phone use that often precede symptoms of stress, anxiety, or depression. While most prior…

Machine Learning · Computer Science 2026-01-14 Kaidong Feng , Zhu Sun , Roy Ka-Wei Lee , Xun Jiang , Yin-Leng Theng , Yi Ding

Understanding the limits of language is a prerequisite for Large Language Models (LLMs) to act as theories of natural language. LLM performance in some language tasks presents both quantitative and qualitative differences from that of…

Computation and Language · Computer Science 2025-06-30 Vittoria Dentella , Fritz Guenther , Evelina Leivada

Recent advances in large language models (LLMs) have shown impressive ability in biomedical question-answering, but have not been adequately investigated for more specific biomedical applications. This study investigates the performance of…

Computation and Language · Computer Science 2024-03-29 Shan Chen , Yingya Li , Sheng Lu , Hoang Van , Hugo JWL Aerts , Guergana K. Savova , Danielle S. Bitterman

With the increasing use of large language models (LLMs), ensuring reliable performance in diverse, real-world environments is essential. Despite their remarkable achievements, LLMs often struggle with adversarial inputs, significantly…

Computation and Language · Computer Science 2024-06-18 Yuqing Wang , Yun Zhao

Objective: To develop and evaluate machine learning (ML) models for predicting length of stay (LOS) in elective spine surgery, with a focus on the benefits of temporal modeling and model interpretability. Materials and Methods: We compared…

Machine Learning · Computer Science 2025-07-17 Ha Na Cho , Sairam Sutari , Alexander Lopez , Hansen Bow , Kai Zheng

Motivational interviewing (MI) promotes behavioural change in substance use disorders. Its fidelity is measured using the Motivational Interviewing Treatment Integrity (MITI) framework. While large language models (LLMs) can potentially…

Computation and Language · Computer Science 2026-03-05 Aishwariya Jha , Prakrithi Shivaprakash , Lekhansh Shukla , Animesh Mukherjee , Prabhat Chand , Pratima Murthy

This paper uses the MIMIC-IV dataset to examine the fairness and bias in an XGBoost binary classification model predicting the Intensive Care Unit (ICU) length of stay (LOS). Highlighting the critical role of the ICU in managing critically…

Machine Learning · Computer Science 2024-01-03 Alexandra Kakadiaris

Thematic analysis provides valuable insights into participants' experiences through coding and theme development, but its resource-intensive nature limits its use in large healthcare studies. Large language models (LLMs) can analyze text at…

Large Language Models (LLMs) represent formidable tools for sequence modeling, boasting an innate capacity for general pattern recognition. Nevertheless, their broader spatial reasoning capabilities, especially applied to numerical…

Robotics · Computer Science 2023-12-05 Manasi Sharma