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Molecule and text representation learning has gained increasing interest due to its potential for enhancing the understanding of chemical information. However, existing models often struggle to capture subtle differences between molecules…

Machine Learning · Computer Science 2025-10-31 Hyuntae Park , Yeachan Kim , SangKeun Lee

Training large language models (LLMs) to reason via reinforcement learning (RL) significantly improves their problem-solving capabilities. In agentic settings, existing methods like ReAct prompt LLMs to explicitly plan before every action;…

Reinforcement learning (RL), large language models (LLMs), and vision-language models (VLMs) have been widely studied in isolation. However, existing infrastructure lacks the ability to deploy agents from different decision-making paradigms…

The integration of large language models (LLMs) into intelligent tutoring systems offers transformative potential for personalized learning in higher education. However, most existing learning path planning approaches lack transparency,…

Artificial Intelligence · Computer Science 2026-01-27 Haoxin Xu , Changyong Qi , Tong Liu , Bohao Zhang , Anna He , Bingqian Jiang , Longwei Zheng , Xiaoqing Gu

Deep reinforcement learning has successfully been applied for molecular discovery as shown by the Molecule Deep Q-network (MolDQN) algorithm. This algorithm has challenges when applied to optimizing new molecules: training such a model is…

Machine Learning · Computer Science 2023-12-05 Huanyi Qin , Denis Akhiyarov , Sophie Loehle , Kenneth Chiu , Mauricio Araya-Polo

Reinforcement learning (RL) agent development traditionally requires substantial expertise and iterative effort, often leading to high failure rates and limited accessibility. This paper introduces Agent$^2$, an LLM-driven…

Artificial Intelligence · Computer Science 2025-10-01 Yuan Wei , Xiaohan Shan , Ran Miao , Jianmin Li

The advancement of large language models (LLMs) has enabled the construction of multi-agent systems to solve complex tasks by dividing responsibilities among specialized agents, such as a planning agent for subgoal generation and a…

Computation and Language · Computer Science 2025-09-12 Minghang Zhu , Zhengliang Shi , Zhiwei Xu , Shiguang Wu , Lingjie Wang , Pengjie Ren , Zhaochun Ren , Zhumin Chen

This paper focuses on embodied task planning, where an agent acquires visual observations from the environment and executes atomic actions to accomplish a given task. Although recent Vision-Language Models (VLMs) have achieved impressive…

Robotics · Computer Science 2026-04-10 Peiran Xu , Jiaqi Zheng , Yadong Mu

Generative models in molecular design tend to be richly parameterized, data-hungry neural models, as they must create complex structured objects as outputs. Estimating such models from data may be challenging due to the lack of sufficient…

Machine Learning · Computer Science 2021-08-17 Kevin Yang , Wengong Jin , Kyle Swanson , Regina Barzilay , Tommi Jaakkola

The creation of high-quality datasets to improve Large Language Model (LLM) reasoning remains a significant challenge, as current methods often suffer from generating low-quality/incorrect answers and limited information richness from…

Computation and Language · Computer Science 2026-01-09 Xianyang Liu , Yilin Liu , Shuai Wang , Hao Cheng , Andrew Estornell , Yuzhi Zhao , Jun Shu , Jiaheng Wei

Large Language Models (LLMs) have emerged as powerful tools for accelerating scientific discovery, yet their static knowledge and hallucination issues hinder autonomous research applications. Recent advances integrate LLMs into agentic…

Artificial Intelligence · Computer Science 2025-12-23 Zeyu Xia , Jinzhe Ma , Congjie Zheng , Shufei Zhang , Yuqiang Li , Hang Su , P. Hu , Changshui Zhang , Xingao Gong , Wanli Ouyang , Lei Bai , Dongzhan Zhou , Mao Su

Large Language Models (LLMs) have shown promise in assisting molecular property prediction tasks but often rely on human-crafted prompts and chain-of-thought templates. While recent advanced large reasoning models like DeepSeek-R1 employ…

Machine Learning · Computer Science 2026-01-21 Xuan Lin , Long Chen , Yile Wang

Multi-Modal Large Language Models (MLLMs), despite being successful, exhibit limited generality and often fall short when compared to specialized models. Recently, LLM-based agents have been developed to address these challenges by…

Computation and Language · Computer Science 2024-10-08 Binxu Li , Tiankai Yan , Yuanting Pan , Jie Luo , Ruiyang Ji , Jiayuan Ding , Zhe Xu , Shilong Liu , Haoyu Dong , Zihao Lin , Yixin Wang

Topology optimization is a widely used design method that produces optimized material distributions for prescribed objectives and constraints through well-established numerical algorithms. Throughout the workflow, engineers make a series of…

Multiagent Systems · Computer Science 2026-05-25 Hyunjee Park , Hayoung Chung

Every molecule ever synthesised can be drawn as a 2D skeletal diagram, yet in modern property prediction this universally available representation has received less focus in favour of molecular graphs, 3D conformers, or billion-parameter…

Computer Vision and Pattern Recognition · Computer Science 2026-05-12 Aaditya Baranwal , Akshaj Gupta , Shruti Vyas , Yogesh S Rawat

Most current molecular language models transfer the masked language model or image-text generation model from natural language processing to molecular field. However, molecules are not solely characterized by atom/bond symbols; they…

Emerging Technologies · Computer Science 2024-11-26 Yifan Wu , Min Zeng , Yang Li , Yang Zhang , Min Li

Monitoring Machine Learning (ML) models in production environments is crucial, yet traditional approaches often yield verbose, low-interpretability outputs that hinder effective decision-making. We propose a cognitive architecture for ML…

Machine Learning · Computer Science 2025-06-12 Gusseppe Bravo-Rocca , Peini Liu , Jordi Guitart , Rodrigo M Carrillo-Larco , Ajay Dholakia , David Ellison

The automation of chemical research through self-driving laboratories (SDLs) promises to accelerate scientific discovery, yet the reliability and granular performance of the underlying AI agents remain critical, under-examined challenges.…

Artificial Intelligence · Computer Science 2025-10-01 Gihan Panapitiya , Emily Saldanha , Heather Job , Olivia Hess

Recent advancements in biology and chemistry have leveraged multi-modal learning, integrating molecules and their natural language descriptions to enhance drug discovery. However, current pre-training frameworks are limited to two…

Machine Learning · Computer Science 2025-02-05 Teng Xiao , Chao Cui , Huaisheng Zhu , Vasant G. Honavar

Molecular property models increasingly support high-stakes drug-discovery decisions, but their outputs are often difficult to audit: classical predictors return scores without rationale, while language models can produce fluent explanations…