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The discovery of polymers with targeted properties is challenged by the vast chemical design space and the limited availability of consistent, high-quality data across multiple properties. In this work, an integrated polymer informatics…

Chemical Physics · Physics 2026-03-31 Sobin Alosious , Yuhan Liu , Jiaxin Xu , Gang Liu , Renzheng Zhang , Meng Jiang , Tengfei Luo

Recent advances in large language models (LLMs) have significantly improved multi-hop question answering (QA) through direct Chain-of-Thought (CoT) reasoning. However, the irreversible nature of CoT leads to error accumulation, making it…

Artificial Intelligence · Computer Science 2025-05-30 Xinjie Zhao , Fan Gao , Xingyu Song , Yingjian Chen , Rui Yang , Yanran Fu , Yuyang Wang , Yusuke Iwasawa , Yutaka Matsuo , Irene Li

Large language models (LLMs), especially Explicit Long Chain-of-Thought (CoT) reasoning models like DeepSeek-R1 and QWQ, have demonstrated powerful reasoning capabilities, achieving impressive performance in commonsense reasoning and…

Computation and Language · Computer Science 2025-08-13 Jiatong Li , Weida Wang , Qinggang Zhang , Junxian Li , Di Zhang , Changmeng Zheng , Shufei Zhang , Xiaoyong Wei , Qing Li

Molecule-and-text cross-modal representation learning has emerged as a promising direction for enhancing the quality of molecular representation, thereby improving performance in various scientific fields. However, most approaches employ a…

Quantitative Methods · Quantitative Biology 2025-03-04 Yikun Zhang , Geyan Ye , Chaohao Yuan , Bo Han , Long-Kai Huang , Jianhua Yao , Wei Liu , Yu Rong

The generation of molecules with desired properties has become increasingly popular, revolutionizing the way scientists design molecular structures and providing valuable support for chemical and drug design. However, despite the potential…

Machine Learning · Computer Science 2024-03-05 Yin Fang , Ningyu Zhang , Zhuo Chen , Lingbing Guo , Xiaohui Fan , Huajun Chen

Dermatological diagnosis requires integrating fine-grained visual perception with expert clinical knowledge. Although Multimodal Large Language Models (MLLMs) facilitate interactive medical image analysis, their application in dermatology…

Computer Vision and Pattern Recognition · Computer Science 2026-05-15 Yize Liu , Siyuan Yan , Ming Hu , Lie Ju , Xieji Li , Feilong Tang , Wei Feng , Zongyuan Ge

A standard ML model is commonly generated by a single method that specifies aspects such as architecture, initialization, training data and hyperparameters configuration. The presented work introduces a novel methodology allowing to define…

Machine Learning · Computer Science 2023-02-07 Andrea Gesmundo

The design of alloys is a multi-scale problem that requires a holistic approach that involves retrieving relevant knowledge, applying advanced computational methods, conducting experimental validations, and analyzing the results, a process…

Artificial Intelligence · Computer Science 2024-07-16 Alireza Ghafarollahi , Markus J. Buehler

Advancements in artificial intelligence for molecular science are necessitating a paradigm shift from purely data-driven predictions to knowledge-guided computational reasoning. Existing molecular models are predominantly proprietary,…

Machine Learning · Computer Science 2026-03-16 Pengfei Liu , Shuang Ge , Jun Tao , Zhixiang Ren

Agentic multimodal models should not only comprehend text and images, but also actively invoke external tools, such as code execution environments and web search, and integrate these operations into reasoning. In this work, we introduce…

Computer Vision and Pattern Recognition · Computer Science 2026-03-12 Jack Hong , Chenxiao Zhao , ChengLin Zhu , Weiheng Lu , Guohai Xu , Xing Yu

The extraction of molecular structures and reaction data from scientific documents is challenging due to their varied, unstructured chemical formats and complex document layouts. To address this, we introduce MolMole, a vision-based deep…

Drug discovery is a lengthy and resource-intensive process composed of multiple stages. Among these stages, lead optimization plays a critical role in transforming early hit compounds into viable drug candidates. This stage requires…

Machine Learning · Computer Science 2026-05-29 Lingxiao Li , Haobo Zhang , Ruohao Fan , Bin Chen , Jiayu Zhou

Reasoning models (RMs), language models (LMs) trained with reinforcement learning to produce long-form natural language reasoning, have been remarkably successful, but they still require large amounts of computation and data to train, and…

Computation and Language · Computer Science 2025-10-27 Cedegao E. Zhang , Cédric Colas , Gabriel Poesia , Joshua B. Tenenbaum , Jacob Andreas

Clinical decision-making requires nuanced reasoning over heterogeneous evidence and traceable justifications. While recent LLM multi-agent systems (MAS) show promise, they largely optimise for outcome accuracy while overlooking…

Artificial Intelligence · Computer Science 2026-02-17 Chaeeun Lee , T. Michael Yates , Pasquale Minervini , T. Ian Simpson

Simultaneously optimizing multiple, frequently conflicting, molecular properties is a key bottleneck in the development of novel therapeutics. Although a promising approach, the efficacy of multi-task learning is often compromised by…

Machine Learning · Computer Science 2025-10-01 Mason Minot , Gisbert Schneider

While passive agents merely follow instructions, proactive agents align with higher-level objectives, such as assistance and safety by continuously monitoring the environment to determine when and how to act. However, developing proactive…

MLLMs exhibit strong reasoning on isolated queries, yet they operate de novo -- solving each problem independently and often repeating the same mistakes. Existing memory-augmented agents mainly store past trajectories for reuse. However,…

Artificial Intelligence · Computer Science 2026-05-05 Weihao Bo , Shan Zhang , Yanpeng Sun , Jingjing Wu , Qunyi Xie , Xiao Tan , Kunbin Chen , Wei He , Xiaofan Li , Na Zhao , Jingdong Wang , Zechao Li

A significant challenge facing researchers in the area of multi-agent reinforcement learning (MARL) pertains to the identification of a library that can offer fast and compatible development for multi-agent tasks and algorithm combinations,…

Machine Learning · Computer Science 2023-11-07 Siyi Hu , Yifan Zhong , Minquan Gao , Weixun Wang , Hao Dong , Xiaodan Liang , Zhihui Li , Xiaojun Chang , Yaodong Yang

Molecular docking is an important tool for structure-based drug design, accelerating the efficiency of drug development. Complex and dynamic binding processes between proteins and small molecules require searching and sampling over a wide…

Chemical Physics · Physics 2024-02-23 Runqiu Shu , Bowen Liu , Zhaoping Xiong , Xiaopeng Cui , Yunting Li , Wei Cui , Man-Hong Yung , Nan Qiao

Agents are LLM-driven components that can mutate environments in powerful, arbitrary ways. Extracting guarantees for the execution of agents in production environments can be challenging due to asynchrony and failures. In this paper, we…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-04-10 Mahesh Balakrishnan , Ashwin Bharambe , Davide Testuggine , David Geraghty , David Mao , Vidhya Venkat , Ilya Mironov , Rithesh Baradi , Gayathri Aiyer , Victoria Dudin
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