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The evolution and emergence of antibiotic resistance is a major public health concern. The understanding of the within-host microbial dynamics combining mutational processes, horizontal gene transfer and resource consumption, is one of the…

Populations and Evolution · Quantitative Biology 2020-03-09 Ramsès Djidjou-Demasse , Samuel Alizon , Mircea T. Sofonea

Bagging (i.e., bootstrap aggregating) involves combining an ensemble of bootstrap estimators. We consider bagging for inference from noisy or incomplete measurements on a collection of interacting stochastic dynamic systems. Each system is…

Methodology · Statistics 2021-12-08 Edward L. Ionides , Kidus Asfaw , Joonha Park , Aaron A. King

Upon infection of their bacterial hosts temperate phages must chose between lysogenic and lytic developmental strategies. Here we apply the game-theoretic bet-hedging strategy introduced by Kelly to derive the optimal lysogenic fraction of…

Populations and Evolution · Quantitative Biology 2015-07-15 Sergei Maslov , Kim Sneppen

In this paper, experimental data is presented and a simple model is developed for the time evolution of a F-amp \textit{E. Coli} culture population. In general, the bacteria life cycle as revealed by monitoring a culture's population…

Populations and Evolution · Quantitative Biology 2019-12-19 Atanu Chatterjee , Nicholas Mears , Abigail Charest , Saad Algarni , Germano Iannnacchione

The applicability of the Fisher equation, which combines diffusion with logistic nonlinearity, to population dynamics of bacterial colonies is studied with the help of explicit analytic solutions for the spatial distribution of a stationary…

Adaptation and Self-Organizing Systems · Physics 2009-11-07 V. M. Kenkre , M. N. Kuperman

When confronted with an undesired cell population, such as bacterial infections or tumors, we seek the most effective treatment, designed to eliminate the population as rapidly as possible. A common practice is to monitor the cells…

Biological Physics · Physics 2025-01-23 Uzi Harush , Ravid Straussman , Baruch Barzel

Reaction-diffusion waves have long been used to describe the growth and spread of populations undergoing a spatial range expansion. Such waves are generally classed as either pulled, where the dynamics are driven by the very tip of the…

Biological Physics · Physics 2021-07-07 Michael Hunter , Nikhil Krishnan , Tongfei Liu , Wolfram Möbius , Diana Fusco

Numerous studies have explored the link between bacterial swimming and the number of flagella, a distinguishing feature of motile multiflagellated bacteria. We revisit this open question using augmented slender-body theory simulations, in…

Biological Physics · Physics 2024-09-04 Maria Tătulea-Codrean , Eric Lauga

The evolution of antibiotic resistance among bacteria threatens our continued ability to treat infectious diseases. The need for sustainable strategies to cure bacterial infections has never been greater. So far, all attempts to restore…

Populations and Evolution · Quantitative Biology 2015-06-12 Christiane P. Goulart , Mentar Mahmudi , Kristina A. Crona , Stephen D. Jacobs , Marcelo Kallmann , Barry G. Hall , Devin C. Greene , Miriam Barlow

The terminase motors of bacteriophages have been shown to be among the strongest active machines in the biomolecular world, being able to package several tens of kilobase pairs of viral genome into a capsid within minutes. Yet these motors…

Models based on surfactant driven instabilities have been employed to describe pattern formation by swarming bacteria. However, by definition, such models cannot account for the effect of bacterial sensing and decision making. Here we…

Phages are one of the most present groups of organisms in the biosphere. Their identification continues and their taxonomies are divergent. However, due to their evolution mode and the complexity of their species ecosystem, their…

Populations and Evolution · Quantitative Biology 2022-01-04 Dung Nguyen , Alix Boc , Abdoulaye Banire Diallo , Vladimir Makarenkov

This work introduces a new statistical physics lattice model of bacteria interacting with anti-microbial drugs that can reproduce qualitative features of resistance emergence and whose model parameters and outputs can be measured with…

Populations and Evolution · Quantitative Biology 2017-05-17 Roberto C. Alamino

Ecological and evolutionary dynamics have been historically regarded as unfolding at broadly separated timescales. However, these two types of processes are nowadays well documented to much more tightly than traditionally assumed,…

Populations and Evolution · Quantitative Biology 2021-11-17 José Camacho Mateu , Matteo Sireci , Miguel A. Muñoz

The basic process of the innate immune system when phagocyte (white blood cell) engulf or swallow a target particle (bacterium or dead cell), is called phagocytosis. We apply the phase field approach in the spirit of [1], that couples the…

Biological Physics · Physics 2021-11-15 Mohammad Abu Hamed , Alexander A. Nepomnyashchy

The infection dynamics of a population under stationary isolation conditions is modeled. It is underlined that the stationary character of the isolation measures can be expected to imply that an effective SIR model with constant parameters…

Populations and Evolution · Quantitative Biology 2021-10-19 Alejandro Cabo Montes de Oca , Nana Geraldine Cabo Bizet

Centrifugation is a widespread laboratory technique used to separate mixtures into fractions characterized by a specific size, weight or density. We demonstrate that centrifugation can be also used to separate swimming cells having…

Soft Condensed Matter · Physics 2014-11-07 Claudio Maggi , Alessia Lepore , Jacopo Solari , Alessandro Rizzo , Roberto Di Leonardo

We study the growth of a population of bacteria in a dynamical hostile environment corresponding to the immune system of the colonised organism. The immune cells evolve as subcritical open clusters of oriented percolation and are…

Populations and Evolution · Quantitative Biology 2013-10-07 Olivier Garet , Régine Marchand

We provide a Galton--Watson model for the growth of a bacterial population in the presence of antibiotics. We assume that bacterial cells either die or duplicate, and the corresponding probabilities depend on the concentration of the…

Applications · Statistics 2021-04-26 Anita Bogdanov , Péter Kevei , Máté Szalai , Dezső Virok

We probe non-equilibrium properties of an active bacterial bath through measurements of correlations of passive tracer particles and the response function of a driven, optically trapped tracer. These measurements demonstrate violation of…

Soft Condensed Matter · Physics 2009-11-13 D. T. N. Chen , A. W. C. Lau , L. A. Hough , M. F. Islam , M. Goulian , T. C. Lubensky , A. G. Yodh