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Hyperspectral imaging provides spatially resolved spectral information. Utilising dual frequency combs as active illumination sources, hyperspectral imaging with ultra-high spectral resolution can be implemented in a scan-free manner when a…
We developed a Bessel light sheet fluorescence microscopy (LSFM) system to enable high-speed, wide-field intra-vital imaging of zebrafish and other thick biological samples. This system uses air objectives for the convenient mounting of…
We report, for the first time, a multi-confocal Fluorescence Correlation Spectroscopy (mFCS) technique which allows parallel measurements at different locations, by combining a Spatial Light Modulator (SLM), with an Electron Multiplying-CCD…
Several matrix approaches were developed to control light propagation through multiple scattering media under illumination of ultrashort pulses of light. These matrices can be recorded either with spectral or temporal resolution. Thanks to…
This paper describes a micro fluorescence in situ hybridization ({\mu}FISH)-based rapid detection of cytogenetic biomarkers on formalin-fixed paraffin embedded (FFPE) tissue sections. We demonstrated this method in the context of detecting…
Advances in silicon photonics have resulted in rapidly increasing complexity of integrated circuits. New methods are desirable that allow direct characterization of individual optical components in-situ, without the need for additional…
The number of photons available by coherent X-ray scattering from a single biomolecule is considerably less because of the extremely small elastic-scattering cross-section and low damage threshold. Even with a high X-ray flux of 3 x 10to 12…
Polarized light microscopy provides unique opportunities for analyzing the molecular order in man-made and natural materials, including biological structures inside living cells, tissues, and whole organisms. 20 years ago, the LC-PolScope…
In multiphoton microscopy, measurements and compression of the laser pulse width at the setup plays an important role in optimizing the fluorescence output with minimal laser power applications. For example, in deep two and three-photon…
Repetition-rate-scanned lasers are practical in accordion frequency comb generation that serves as a variable gearbox connecting optical and radio wave domains. Rapid and wide-range scanned repetition rate can benefit versatile purposes,…
We present an entirely fiber based laser source for non-linear imaging with a novel approach for multi-color excitation. The high power output of an actively modulated and amplified picosecond fiber laser at 1064 nm is shifted to longer…
We report on multi-photon statistics of correlated twin beams produced in a periodic poled micro-ring resonator on thin-film lithium niobate. Owing to high cavity confinement and near perfect quasi-phase matching, the photons pairs are…
Fluorescence microscopy and derived techniques are continuously looking for photodetectors able to guarantee increased sensitivity, high spatial and temporal resolution and ease of integration into modern microscopy architectures. Recent…
Hyperspectral imaging is a technique that allows for the creation of multi-color images. At terahertz wavelengths, it has emerged as a prominent tool for a number of applications, ranging from non-ionizing cancer diagnosis and…
Robust voltage imaging in tissue remains a technical challenge. Existing combinations of genetically encoded voltage indicators (GEVIs) and microscopy techniques cannot simultaneously achieve sufficiently high voltage sensitivity,…
Label-Free Multiphoton Microscopy is a very powerful optical microscopy that can be applied to study samples with no need for exogenous fluorescent probes, keeping the main benefits of a Multiphoton approach, like longer penetration depths…
The extraction of information carried by light plays an increasingly important role in optical communication, imaging, and detection. However, the information can only be successfully extracted when the light pulse is comparably strong,…
We propose a compact snapshot monocular depth estimation technique that relies on an engineered point spread function (PSF). Traditional approaches used in microscopic super-resolution imaging such as the Double-Helix PSF (DHPSF) are…
We demonstrate the capabilities of a highly parallel, active pixel detector for large-area, mass spectrometric imaging of biological tissue sections. A bare Timepix assembly (512x512 pixels) is combined with chevron microchannel plates on…
A rapid and efficient photo-bleaching process was demonstrated with a high-energy nanosecond pulse to recover existing and/or revealed color centers on 10 kGy Gamma-irradiated Yb-doped optical fiber. Multi-mJ pulsed laser based on an…