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Microscopic interpretation of histopathology images underlies many important diagnostic and treatment decisions. While advances in vision-language modeling raise new opportunities for analysis of such images, the gigapixel-scale size of…

Vision-language models like CLIP show impressive ability to align images and text, but their training on short, concise captions makes them struggle with lengthy, detailed descriptions. Recent advances mitigate this challenge by leveraging…

Computer Vision and Pattern Recognition · Computer Science 2025-12-16 Chau Truong , Hieu Ta Quang , Dung D. Le

In Computational Pathology (CPath), the introduction of Vision-Language Models (VLMs) has opened new avenues for research, focusing primarily on aligning image-text pairs at a single magnification level. However, this approach might not be…

Computer Vision and Pattern Recognition · Computer Science 2025-04-29 Shahad Albastaki , Anabia Sohail , Iyyakutti Iyappan Ganapathi , Basit Alawode , Asim Khan , Sajid Javed , Naoufel Werghi , Mohammed Bennamoun , Arif Mahmood

While the Contrastive Language-Image Pretraining(CLIP) model has achieved remarkable success in a variety of downstream vison language understanding tasks, enhancing its capability for fine-grained image-text alignment remains an active…

Computer Vision and Pattern Recognition · Computer Science 2025-11-07 Yicheng Xiao , Yu Chen , Haoxuan Ma , Jiale Hong , Caorui Li , Lingxiang Wu , Haiyun Guo , Jinqiao Wang

Whole Slide Images (WSIs) exhibit hierarchical structure, where diagnostic information emerges from cellular morphology, regional tissue organization, and global context. Existing Computational Pathology (CPath) Multimodal Large Language…

Computer Vision and Pattern Recognition · Computer Science 2026-03-26 Basit Alawode , Arif Mahmood , Muaz Khalifa Al-Radi , Shahad Albastaki , Asim Khan , Muhammad Bilal , Moshira Ali Abdalla , Mohammed Bennamoun , Sajid Javed

Vision Language Models (VLMs) like CLIP have attracted substantial attention in pathology, serving as backbones for applications such as zero-shot image classification and Whole Slide Image (WSI) analysis. Additionally, they can function as…

Computer Vision and Pattern Recognition · Computer Science 2024-07-02 Yuxuan Sun , Yunlong Zhang , Yixuan Si , Chenglu Zhu , Zhongyi Shui , Kai Zhang , Jingxiong Li , Xingheng Lyu , Tao Lin , Lin Yang

As CLIP's global alignment limits its ability to capture fine-grained details, recent efforts have focused on enhancing its region-text alignment. However, current remote sensing (RS)-specific CLIP variants still inherit this limited…

Computer Vision and Pattern Recognition · Computer Science 2025-11-20 Zhenshi Li , Weikang Yu , Dilxat Muhtar , Xueliang Zhang , Pengfeng Xiao , Pedram Ghamisi , Xiao Xiang Zhu

Whole slide images (WSIs) in computational pathology (CPath) pose a major computational challenge due to their gigapixel scale, often requiring the processing of tens to hundreds of thousands of high-resolution patches per slide. This…

Computer Vision and Pattern Recognition · Computer Science 2025-08-21 Yonghan Shin , SeungKyu Kim , Won-Ki Jeong

The rapid digitization of histopathology slides has opened up new possibilities for computational tools in clinical and research workflows. Among these, content-based slide retrieval stands out, enabling pathologists to identify…

Computer Vision and Pattern Recognition · Computer Science 2025-10-28 Hongyi Wang , Zhengjie Zhu , Jiabo Ma , Fang Wang , Yue Shi , Bo Luo , Jili Wang , Qiuyu Cai , Xiuming Zhang , Yen-Wei Chen , Lanfen Lin , Hao Chen

In this paper, we address the challenge of few-shot classification in histopathology whole slide images (WSIs) by utilizing foundational vision-language models (VLMs) and slide-level prompt learning. Given the gigapixel scale of WSIs,…

Computer Vision and Pattern Recognition · Computer Science 2025-03-24 Devavrat Tomar , Guillaume Vray , Dwarikanath Mahapatra , Sudipta Roy , Jean-Philippe Thiran , Behzad Bozorgtabar

Whole Slide Image (WSI) classification is often formulated as a Multiple Instance Learning (MIL) problem. Recently, Vision-Language Models (VLMs) have demonstrated remarkable performance in WSI classification. However, existing methods…

Computer Vision and Pattern Recognition · Computer Science 2024-04-08 Hao Li , Ying Chen , Yifei Chen , Wenxian Yang , Bowen Ding , Yuchen Han , Liansheng Wang , Rongshan Yu

CLIP has shown impressive results in aligning images and texts at scale. However, its ability to capture detailed visual features remains limited because CLIP matches images and texts at a global level. To address this issue, we propose…

Computer Vision and Pattern Recognition · Computer Science 2024-12-05 Rui Xiao , Sanghwan Kim , Mariana-Iuliana Georgescu , Zeynep Akata , Stephan Alaniz

Despite the success of Vision-Language Models (VLMs) like CLIP in aligning vision and language, their proficiency in detailed, fine-grained visual comprehension remains a key challenge. We present CLIP-IN, a novel framework that bolsters…

Computer Vision and Pattern Recognition · Computer Science 2025-11-18 Ziteng Wang , Siqi Yang , Limeng Qiao , Lin Ma

Whole slide pathology image classification presents challenges due to gigapixel image sizes and limited annotation labels, hindering model generalization. This paper introduces a prompt learning method to adapt large vision-language models…

Medical vision-language pretraining (VLP) that leverages naturally-paired medical image-report data is crucial for medical image analysis. However, existing methods struggle to accurately characterize associations between images and…

Computer Vision and Pattern Recognition · Computer Science 2025-01-22 Xinjie Liang , Xiangyu Li , Fanding Li , Jie Jiang , Qing Dong , Wei Wang , Kuanquan Wang , Suyu Dong , Gongning Luo , Shuo Li

In the field of computational histopathology, both whole slide images (WSIs) and diagnostic captions provide valuable insights for making diagnostic decisions. However, aligning WSIs with diagnostic captions presents a significant…

Computer Vision and Pattern Recognition · Computer Science 2025-03-18 Qifeng Zhou , Wenliang Zhong , Yuzhi Guo , Michael Xiao , Hehuan Ma , Junzhou Huang

Pathological diagnosis is vital for determining disease characteristics, guiding treatment, and assessing prognosis, relying heavily on detailed, multi-scale analysis of high-resolution whole slide images (WSI). However, existing large…

Computer Vision and Pattern Recognition · Computer Science 2025-05-19 Shengxuming Zhang , Weihan Li , Tianhong Gao , Jiacong Hu , Haoming Luo , Xiuming Zhang , Jing Zhang , Mingli Song , Zunlei Feng

Current multi-instance learning algorithms for pathology image analysis often require a substantial number of Whole Slide Images for effective training but exhibit suboptimal performance in scenarios with limited learning data. In clinical…

Computer Vision and Pattern Recognition · Computer Science 2024-07-16 Linhao Qu , Dingkang Yang , Dan Huang , Qinhao Guo , Rongkui Luo , Shaoting Zhang , Xiaosong Wang

Artificial intelligence (AI) shows great potential in assisting radiologists to improve the efficiency and accuracy of medical image interpretation and diagnosis. However, a versatile AI model requires large-scale data and comprehensive…

Computer Vision and Pattern Recognition · Computer Science 2025-01-27 Zhongyi Shui , Jianpeng Zhang , Weiwei Cao , Sinuo Wang , Ruizhe Guo , Le Lu , Lin Yang , Xianghua Ye , Tingbo Liang , Qi Zhang , Ling Zhang

The emergence of foundation models in computational pathology has transformed histopathological image analysis, with whole slide imaging (WSI) diagnosis being a core application. Traditionally, weakly supervised fine-tuning via multiple…

Computer Vision and Pattern Recognition · Computer Science 2025-03-03 Jiawen Li , Jiali Hu , Qiehe Sun , Renao Yan , Minxi Ouyang , Tian Guan , Anjia Han , Chao He , Yonghong He
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