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We study the conditions on the physical parameters in the Helfrich bending energy of lipid bilayer vesicles. Among embedded surfaces with a biconcave axisymmetric shape, the variation equation is analyzed in detail. This leads to simple…

Analysis of PDEs · Mathematics 2007-05-23 Thomas Kwok-keung Au , Tom Yau-heng Wan

Systems of spherical particles moving in Stokes flow are studied for a different particle internal structure and boundaries, including the Navier-slip model. It is shown that their hydrodynamic interactions are well described by treating…

Soft Condensed Matter · Physics 2015-06-18 Bogdan Cichocki , Maria L. Ekiel-Jezewska , Eligiusz Wajnryb

Fluid deformable surfaces are ubiquitous in cell and tissue biology, including lipid bilayers, the actomyosin cortex, or epithelial cell sheets. These interfaces exhibit a complex interplay between elasticity, low Reynolds number…

Fluid Dynamics · Physics 2019-06-12 Alejandro Torres-Sánchez , Daniel Millán , Marino Arroyo

With the aim of establishing a criterion for identifying when a lipid bilayer has reached steady state using the molecular dynamics simulation technique, lipid bilayers of different composition in their liquid crystalline phase were…

Soft Condensed Matter · Physics 2012-12-13 Rodolfo D. Porasso , José J. López Cascales

A minimalist simulation model for lipid bilayers is presented. Each lipid is represented by a flexible chain of beads in implicit solvent. The hydrophobic effect is mimicked through an intermolecular pair potential localized at the…

Statistical Mechanics · Physics 2009-11-11 Grace Brannigan , Peter F. Philips , Frank L. H. Brown

We introduce several new models whose common feature is to take into account effects from topological vorticity. The macroscopic unknown is driven by a dissipative anomalous diffusion (of SQG-type) and is coupled with the orientation of the…

Analysis of PDEs · Mathematics 2026-01-27 Fanghua Lin , Yannick Sire , Yantao Wu , Yifu Zhou

We consider shape and topology optimization for fluids which are governed by the Navier--Stokes equations. Shapes are modelled with the help of a phase field approach and the solid body is relaxed to be a porous medium. The phase field…

Optimization and Control · Mathematics 2015-04-27 Harald Garcke , Claudia Hecht , Michael Hinze , Christian Kahle , Kei Fong Lam

We present a stochastic phase-field model for multicomponent lipid bilayers that explicitly accounts for the quasi-two-dimensional hydrodynamic environment unique to a thin fluid membrane immersed in aqueous solution. Dynamics over a wide…

Soft Condensed Matter · Physics 2011-05-26 Brian A. Camley , Frank L. H. Brown

A lattice model for binary mixture of lipids and water is introduced and investigated. The orientational degrees of freedom of the amphiphilic molecules are taken into account in the same way as in the model for oil-water-surfactant…

Soft Condensed Matter · Physics 2014-07-04 Alina Ciach , Jakub Pękalski

The effect of rigid surfaces on the dynamics of thin liquid films which are amenable to the lubrication approximation is considered. It is shown that the Helfrich energy of the layer gives rise to additional terms in the time-evolution…

Pattern Formation and Solitons · Physics 2015-05-27 Michael H. Köpf , Svetlana V. Gurevich , Thomas Wulf , Rudolf Friedrich

Amphiphilic polymers in aqueous solutions can self-assemble to form bilayer membranes, and their elastic properties can be captured by the well-known Helfrich model involving several elastic constants. In this paper, we employ the…

Soft Condensed Matter · Physics 2024-03-06 Yongshun Luo , Min Yang , Sirui Li , Yana Di , Yongqiang Cai

We derive a novel thermodynamically consistent Navier--Stokes--Cahn--Hilliard system with dynamic boundary conditions. This model describes the motion of viscous incompressible binary fluids with different densities. In contrast to previous…

Analysis of PDEs · Mathematics 2023-10-25 Andrea Giorgini , Patrik Knopf

Liquid droplets sliding along solid surfaces are a frequently observed phenomenon in nature, e.g., raindrops on a leaf, and in everyday situations, e.g., drops of water in a drinking glass. To model this situation, we use a phase field…

Computational Physics · Physics 2019-10-23 Henning Bonart , Christian Kahle , Jens-Uwe Repke

We use dynamical systems theory to construct the normal form of the Navier--Stokes equations for the flow of a thin layer of fluid upon a solid substrate. The normal form equations illuminate the fluid dynamics by decoupling the long-term…

Chaotic Dynamics · Physics 2007-05-23 A. J. Roberts

We consider the hydrodynamics of lipid bilayers containing transmembrane proteins of arbitrary shape. This biologically-motivated problem is relevant to the cell membrane, whose fluctuating dynamics play a key role in phenomena ranging from…

Soft Condensed Matter · Physics 2016-10-10 Andrew Callan-Jones , Marc Durand , Jean-Baptiste Fournier

We present a simple, and physically motivated, coarse-grained model of a lipid bilayer, suited for micron scale computer simulations. Each ~25 nm^2 patch of bilayer is represented by a spherical particle. Mimicking forces of hydrophobic…

Soft Condensed Matter · Physics 2015-05-13 Andrea Pasqua , Lutz Maibaum , George Oster , Daniel A. Fletcher , Phillip L. Geissler

The Helfrich functional, denoted by H^{c_0}, is a mathematical expression proposed by Helfrich (1973) for the natural free energy carried by an elastic phospholipid bilayer. Helfrich theorises that idealised elastic phospholipid bilayers…

Mathematical Physics · Physics 2018-11-22 Yann Bernard , Glen Wheeler , Valentina-Mira Wheeler

We study a model of a lipid bilayer membrane described by two order parameters: the chemical composition described using the Gaussian model and the spatial configuration described with the elastic deformation model of a membrane with a…

Soft Condensed Matter · Physics 2022-06-08 Piotr Nowakowski , Bernd Henning Stumpf , Ana-Sunčana Smith , Anna Maciołek

We review recent computer simulation studies of undulating lipid bilayers. Theoretical interpretations of such fluctuating membranes are most commonly based on generalized Helfrich-type elastic models, with additional contributions of local…

Biological Physics · Physics 2013-09-03 Friederike Schmid

We consider a model of bilayer lipid membrane with bola-lipids. The bola-lipid is modeled by linking tails of the hydrophobic chains in the opposite monolayers within bilayer as a first approximation. A number of thermodynamical…

Biomolecules · Quantitative Biology 2016-02-26 Sergei I. Mukhin , Boris B. Kheyfets