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Background and Objective: Transcranial temporal interference stimulation (tTIS) is a promising non-invasive brain stimulation technique in which interference between electrical current fields extends the possibilities of electrical brain…

Numerical Analysis · Mathematics 2026-02-05 Santtu Söderholm , Maryam Samavaki , Sampsa Pursiainen

Transcranial magnetic stimulation (TMS) is a technique for noninvasively stimulating a brain area for therapeutic, rehabilitation treatments and neuroscience research. Despite our understanding of the physical principles and experimental…

Neurons and Cognition · Quantitative Biology 2020-12-30 Jose Gomez-Tames , Ilkka Laakso , Akimasa Hirata

Deep Brain Stimulation (DBS) is effective in treating neurological disorders but involves invasive surgery. Non-invasive DBS aims to overcome surgical risks by means of externally applied electromagnetic fields. In this work, we present a…

Medical Physics · Physics 2026-02-24 Mika Söderström , Melker Carlsson , Patrik Nicolausson , Mariana Dalarsson

Transcranial electric stimulation (TES) can modulate intrinsic neural activity in the brain by injecting weak currents through electrodes attached to the scalp. TES has been widely used as a neuroscience tool to investigate how behavioural…

Spinal cord injury (SCI) is a debilitating condition that often results in significant motor and sensory deficits, impacting the quality of life. Current rehabilitation methods, including physical therapy and electrical stimulation, offer…

Neurons and Cognition · Quantitative Biology 2024-12-18 Ruidong Cheng , Yuling Shao , Xi Li , Li Zhang , Zehao Sheng , Chenyang Li , Xu Xie , Huilin Mou , Weidong Chen , Shaomin Zhang , Yuchen Xu , Minmin Wang

Low-intensity transcranial focused ultrasound (tFUS) is rapidly emerging as a transformative non-invasive brain stimulation (NIBS) modality characterized by high spatial resolution and ability to target deep brain circuits. Unlike…

Neurons and Cognition · Quantitative Biology 2026-04-02 William J. Tyler

Background: Spinal cord injury (SCI) rehabilitation remains a major clinical challenge, with limited treatment options for functional recovery. Temporal interference (TI) electrical stimulation has emerged as a promising non-invasive…

Medical Physics · Physics 2025-03-07 Xu Xie , Yuchen Xu , Huilin Mou , Xi Li , Li Zhang , Zehao Sheng , Weidong Chen , Shaomin Zhang , Ruidong Cheng , Minmin Wang

Objective. Personalized transcranial electrical stimulation (tES) has gained growing attention due to the substantial inter-individual variability in brain anatomy and physiology. While previous reviews have discussed the physiological…

Neurons and Cognition · Quantitative Biology 2025-11-06 Mo Wang , Kexin Zheng , Yingyue Xin , Xiang Chen , Yiling Liu , Huichun Luo , Jingsheng Tang , Tifei Yuan , Hongkai Wen , Pengfei Wei , Quanying Liu

Identifying what aspects of brain activity are responsible for conscious perception remains one of the most challenging problems in science. While progress has been made through psychophysical studies employing EEG and fMRI, research would…

Neurons and Cognition · Quantitative Biology 2025-07-14 Daniel K. Freeman , Brian Odegaard , Seung-Schik Yoo , Matthias Michel

Temporal Interference Stimulation (TIS) is a non-invasive neuromodulation technique in which two high-frequency sinusoidal currents with slightly different frequencies generate a low-frequency envelope that can activate deep neural…

Dynamical Systems · Mathematics 2026-05-19 Esteban Paduro , Antoine Chaillet , Mario Sigalotti

A major shortcoming of medical practice is the lack of an objective measure of conscious level. Impairment of consciousness is common, e.g. following brain injury and seizures, which can also interfere with sensory processing and volitional…

Neurons and Cognition · Quantitative Biology 2025-12-24 Alexis Pomares Pastor , Ines Ribeiro Violante , Gregory Scott

Advancements in neurosurgical robotics have improved medical procedures, particularly deep brain stimulation, where robots combine human and machine intelligence to precisely implant electrodes in the brain. While effective, this procedure…

Systems and Control · Electrical Eng. & Systems 2023-12-14 Mobina Zibandepour , Akram Shojaei , Arash Abbasi Larki , Mehdi Delrobaei

The main objective of the electrical stimulation of the brain is to generate action potentials from the application of electromagnetic fields. Among the available techniques, transcranial electrical stimulation (TES) represents a popular…

Medical Physics · Physics 2015-11-09 Carlos G. Tarazona , Carlos E. Guerra , Laura Chávez , Sebastián Andrade

Transcranial focused ultrasound (tFUS) is an emerging form of non-surgical human neuromodulation that confers advantages over existing electro and electromagnetic technologies by providing a superior spatial resolution on the millimeter…

Neurons and Cognition · Quantitative Biology 2016-03-02 Leo Ai , Jerel K. Mueller , Andrea Grant , Yigitcan Eryaman , Wynn Legon

We present a real-time visualization system for Transcranial Magnetic Stimulation (TMS), a non-invasive neuromodulation technique for treating various brain disorders and mental health diseases. Our solution targets the current challenges…

Signal Processing · Electrical Eng. & Systems 2024-03-14 Loraine Franke , Tae Young Park , Jie Luo , Yogesh Rathi , Steve Pieper , Lipeng Ning , Daniel Haehn

Electro-stimulation or modulation of deep brain regions is commonly used in clinical procedures for the treatment of several nervous system disorders. In particular, transcranial direct current stimulation (tDCS) is widely used as an…

Image and Video Processing · Electrical Eng. & Systems 2020-04-29 Essam A. Rashed , Jose Gomez-Tames , Akimasa Hirata

Electromagnetic stimulation of the human brain is a key tool for the neurophysiological characterization and diagnosis of several neurological disorders. Transcranial magnetic stimulation (TMS) is one procedure that is commonly used…

Machine Learning · Computer Science 2020-02-04 Essam A. Rashed , Jose Gomez-Tames , Akimasa Hirata

Transcranial magnetic stimulation (TMS) is a popular method for the noninvasive stimulation of neurons in the brain. It has become a standard instrument in experimental brain research and is approved for a range of diagnostic and…

Medical Physics · Physics 2023-12-27 Max Koehler , Stefan Goetz

Non-invasive brain stimulation, such as transcranial alternating current stimulation (tACS) provides a powerful tool to directly modulate brain oscillations that mediate complex cognitive processes. While the body of evidence about the…

Purpose: This study investigates the feasibility of transcutaneous interferential spinal cord stimulation (tISCS), a novel non-invasive neuromodulation method, using temporal interference to enhance focality and comfort in spinal cord…

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