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Multimodal Large Language Models (MLLMs) are increasingly applied in real-world scenarios where user-provided images are often imperfect, requiring active image manipulations such as cropping, editing, or enhancement to uncover salient…

Vision language models (VLMs) achieve strong performance on general image understanding but struggle to think with medical images, especially when performing multi-step reasoning through iterative visual interaction. Medical VLMs often rely…

Computer Vision and Pattern Recognition · Computer Science 2026-01-13 Meng Lu , Yuxing Lu , Yuchen Zhuang , Megan Mullins , Yang Xie , Guanghua Xiao , Charles Fleming , Wenqi Shi , Xuan Wang

Following OpenAI's introduction of the ``thinking with images'' concept, recent efforts have explored stimulating the use of visual information in the reasoning process to enhance model performance in perception and reasoning tasks.…

Medical imaging provides critical evidence for clinical diagnosis, treatment planning, and surgical decisions, yet most existing imaging models are narrowly focused and require multiple specialized networks, limiting their generalization.…

Computer Vision and Pattern Recognition · Computer Science 2025-09-25 Guoxin Wang , Jun Zhao , Xinyi Liu , Yanbo Liu , Xuyang Cao , Chao Li , Zhuoyun Liu , Qintian Sun , Fangru Zhou , Haoqiang Xing , Zhenhong Yang

Chain-of-Thought (CoT) reasoning has proven effective in enhancing large language models by encouraging step-by-step intermediate reasoning, and recent advances have extended this paradigm to Multimodal Large Language Models (MLLMs). In the…

Image and Video Processing · Electrical Eng. & Systems 2026-03-24 Juntao Jiang , Jiangning Zhang , Yali Bi , Jinsheng Bai , Weixuan Liu , Weiwei Jin , Zhucun Xue , Yong Liu , Xiaobin Hu , Shuicheng Yan

Large Vision-Language Models excel at multimodal understanding but struggle to deeply integrate visual information into their predominantly text-based reasoning processes, a key challenge in mirroring human cognition. To address this, we…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Ziwei Zheng , Michael Yang , Jack Hong , Chenxiao Zhao , Guohai Xu , Le Yang , Chao Shen , Xing Yu

Frontier models are transitioning from multimodal large language models (MLLMs) that merely ingest visual information to unified multimodal models (UMMs) capable of native interleaved generation. This shift has sparked interest in using…

The frontier of visual reasoning is shifting toward models like OpenAI o3, which can intelligently create and operate tools to transform images for problem-solving, also known as thinking-\textit{with}-images in chain-of-thought. Yet…

Computer Vision and Pattern Recognition · Computer Science 2025-11-07 Ming Li , Jike Zhong , Shitian Zhao , Haoquan Zhang , Shaoheng Lin , Yuxiang Lai , Chen Wei , Konstantinos Psounis , Kaipeng Zhang

Multimodal large language models (MLLMs) demonstrate significant potential in the field of medical diagnosis. However, they face critical challenges in specialized domains such as ophthalmology, particularly the fragmentation of annotation…

Artificial Intelligence · Computer Science 2025-07-24 Xinyao Liu , Diping Song

Multimodal Large Language Models (MLLMs) have demonstrated impressive capabilities in understanding common visual elements, largely due to their large-scale datasets and advanced training strategies. However, their effectiveness in medical…

Solving complex reasoning tasks may involve visual understanding, domain knowledge retrieval, numerical calculation, and multi-step reasoning. Existing methods augment large language models (LLMs) with external tools but are restricted to…

Machine Learning · Computer Science 2026-04-15 Pan Lu , Bowen Chen , Sheng Liu , Rahul Thapa , Joseph Boen , James Zou

While humans can flexibly leverage interactive visual cognition for complex problem-solving, enabling Large Vision-Language Models (LVLMs) to learn similarly adaptive behaviors with visual tools remains challenging. A significant hurdle is…

Computer Vision and Pattern Recognition · Computer Science 2025-07-10 Zhaochen Su , Linjie Li , Mingyang Song , Yunzhuo Hao , Zhengyuan Yang , Jun Zhang , Guanjie Chen , Jiawei Gu , Juntao Li , Xiaoye Qu , Yu Cheng

As a cornerstone of patient care, clinical decision-making significantly influences patient outcomes and can be enhanced by large language models (LLMs). Although LLMs have demonstrated remarkable performance, their application to visual…

Computer Vision and Pattern Recognition · Computer Science 2025-06-16 Ji Young Byun , Young-Jin Park , Navid Azizan , Rama Chellappa

Despite the remarkable progress of Vision-Language Models (VLMs) in adopting "Thinking-with-Images" capabilities, accurately evaluating the authenticity of their reasoning process remains a critical challenge. Existing benchmarks mainly…

Computer Vision and Pattern Recognition · Computer Science 2026-01-21 Xuchen Li , Xuzhao Li , Renjie Pi , Shiyu Hu , Jian Zhao , Jiahui Gao

Multi-agent AI systems powered by large language models (LLMs) are increasingly applied to solve complex tasks. However, these systems often rely on fragile, manually designed prompts and heuristics, making optimization difficult. A key…

Artificial Intelligence · Computer Science 2025-02-10 Wanjia Zhao , Mert Yuksekgonul , Shirley Wu , James Zou

Recent advances in large Vision-Language Models (VLMs) have exhibited strong reasoning capabilities on complex visual tasks by thinking with images in their Chain-of-Thought (CoT), which is achieved by actively invoking tools to analyze…

Computer Vision and Pattern Recognition · Computer Science 2026-01-08 Wenhao Yang , Yu Xia , Jinlong Huang , Shiyin Lu , Qing-Guo Chen , Zhao Xu , Weihua Luo , Kaifu Zhang , Yuanyu Wan , Lijun Zhang

While Multimodal Large Language Models (MLLMs) excel at single-image understanding, they exhibit significantly degraded performance in multi-image reasoning scenarios. Multi-image reasoning presents fundamental challenges including complex…

Computer Vision and Pattern Recognition · Computer Science 2026-01-13 Jianghao Yin , Qingbin Li , Kun Sun , Cheng Ding , Jie Wang , Qin Chen , Jie Zhou , Nan Wang , Changqing Li , Pei Wu , Jian Xu , Zheming Yang , Liang He

Large language models (LLMs) and multimodal large language models (MLLMs) have significantly advanced artificial intelligence. However, visual reasoning, reasoning involving both visual and textual inputs, remains underexplored. Recent…

Computer Vision and Pattern Recognition · Computer Science 2025-04-18 I-Sheng Fang , Jun-Cheng Chen

We present Thinking with Generated Images, a novel paradigm that fundamentally transforms how large multimodal models (LMMs) engage with visual reasoning by enabling them to natively think across text and vision modalities through…

Computer Vision and Pattern Recognition · Computer Science 2025-05-29 Ethan Chern , Zhulin Hu , Steffi Chern , Siqi Kou , Jiadi Su , Yan Ma , Zhijie Deng , Pengfei Liu

Medical Image Quality Assessment (IQA) serves as the first-mile safety gate for clinical AI, yet existing approaches remain constrained by scalar, score-based metrics and fail to reflect the descriptive, human-like reasoning process central…

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