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Randomized clinical trials are the gold standard for analyzing treatment effects, but high costs and ethical concerns can limit recruitment, potentially leading to invalid inferences. Incorporating external trial data with similar…

Methodology · Statistics 2024-09-09 Yujia Gu , Hanzhong Liu , Wei Ma

Electronic Health Records (EHR) contain valuable clinical information for predicting patient outcomes and guiding healthcare decisions. However, effectively modeling Electronic Health Records (EHRs) requires addressing data heterogeneity…

Machine Learning · Computer Science 2025-07-22 Junhan Yu , Zhunyi Feng , Junwei Lu , Tianxi Cai , Doudou Zhou

With recent achievements in tasks requiring context awareness, foundation models have been adopted to treat large-scale data from electronic health record (EHR) systems. However, previous clinical recommender systems based on foundation…

Artificial Intelligence · Computer Science 2023-02-02 Seunghyun Lee , Da Young Lee , Sujeong Im , Nan Hee Kim , Sung-Min Park

Recent advances in transformer architectures have revolutionised natural language processing, but their application to healthcare domains presents unique challenges. Patient timelines are characterised by irregular sampling, variable…

Computation and Language · Computer Science 2025-05-26 Linglong Qian , Zina Ibrahim

Causal Temporal Representation Learning (Ctrl) methods aim to identify the temporal causal dynamics of complex nonstationary temporal sequences. Despite the success of existing Ctrl methods, they require either directly observing the domain…

Machine Learning · Computer Science 2024-09-06 Xiangchen Song , Zijian Li , Guangyi Chen , Yujia Zheng , Yewen Fan , Xinshuai Dong , Kun Zhang

Transfer learning is beneficial for survival analysis, especially when the target study has a limited number of events. However, existing transfer learning methods rely on the restrictive assumption that the target and source studies share…

Methodology · Statistics 2026-03-13 Yu Gu , Donglin Zeng , D. Y. Lin

With the wide application of electronic health records (EHR) in healthcare facilities, health event prediction with deep learning has gained more and more attention. A common feature of EHR data used for deep-learning-based predictions is…

Machine Learning · Computer Science 2021-12-17 Chang Lu , Tian Han , Yue Ning

The hypothesis that computational models can be reliable enough to be adopted in prognosis and patient care is revolutionizing healthcare. Deep learning, in particular, has been a game changer in building predictive models, thus leading to…

Machine Learning · Statistics 2019-06-17 Jayaraman J. Thiagarajan , Deepta Rajan , Prasanna Sattigeri

In clinical research and clinical decision-making, it is important to know if a study changes or only supports the current standards of care for specific disease management. We define such a change as transformative and a support as…

Computation and Language · Computer Science 2021-12-28 Xuanyu Shi , Jian Du

In the past few years, time series foundation models have achieved superior predicting accuracy. However, real-world time series often exhibit significant diversity in their temporal patterns across different time spans and domains, making…

Machine Learning · Computer Science 2026-03-19 Aobo Liang , Yan Sun , Xiaohou Shi , Ke Li

Accurate and robust drug response prediction is of utmost importance in precision medicine. Although many models have been developed to utilize the representations of drugs and cancer cell lines for predicting cancer drug responses (CDR),…

Quantitative Methods · Quantitative Biology 2023-11-22 Xiaoqiong Xia , Chaoyu Zhu , Yuqi Shan , Fan Zhong , Lei Liu

Deep neural networks have shown promising results for various clinical prediction tasks. However, training deep networks such as those based on Recurrent Neural Networks (RNNs) requires large labeled data, significant hyper-parameter tuning…

Machine Learning · Computer Science 2021-03-05 Priyanka Gupta , Pankaj Malhotra , Jyoti Narwariya , Lovekesh Vig , Gautam Shroff

Recently, researchers have started applying convolutional neural networks (CNNs) with one-dimensional convolutions to clinical tasks involving time-series data. This is due, in part, to their computational efficiency, relative to recurrent…

Machine Learning · Computer Science 2019-02-19 Jeeheh Oh , Jiaxuan Wang , Jenna Wiens

The significance of efficient and accurate diagnosis amidst the unique challenges posed by the COVID-19 pandemic underscores the urgency for innovative approaches. In response to these challenges, we propose a transfer learning-based…

Image and Video Processing · Electrical Eng. & Systems 2023-12-12 Kenan Morani , Esra Kaya Ayana , Devrim Unay

COVID-19 has challenged health systems to learn how to learn. This paper describes the context, methods and challenges for learning to improve COVID-19 care at one academic health center. Challenges to learning include: (1) choosing a right…

Adverse clinical events related to unsafe care are among the top ten causes of death in the U.S. Accurate modeling and prediction of clinical events from electronic health records (EHRs) play a crucial role in patient safety enhancement. An…

Machine Learning · Computer Science 2024-12-20 Tingsong Xiao , Zelin Xu , Wenchong He , Zhengkun Xiao , Yupu Zhang , Zibo Liu , Shigang Chen , My T. Thai , Jiang Bian , Parisa Rashidi , Zhe Jiang

Timely and personalized treatment decisions are essential across a wide range of healthcare settings where patient responses can vary significantly and evolve over time. Clinical data used to support these treatment decisions are often…

Machine Learning · Computer Science 2025-12-03 Qianyi Xu , Gousia Habib , Feng Wu , Dilruk Perera , Mengling Feng

Medical texts, particularly electronic medical records (EMRs), are a cornerstone of modern healthcare, capturing critical information about patient care, diagnoses, and treatments. These texts hold immense potential for advancing clinical…

Computation and Language · Computer Science 2025-11-12 Mucheng Ren , Yucheng Yan , He Chen , Danqing Hu , Jun Xu , Xian Zeng

In applied machine learning, concept drift, which is either gradual or abrupt changes in data distribution, can significantly reduce model performance. Typical detection methods,such as statistical tests or reconstruction-based models,are…

Machine Learning · Computer Science 2025-08-12 N Harshit , K Mounvik

During an infectious disease pandemic, it is critical to share electronic medical records or models (learned from these records) across regions. Applying one region's data/model to another region often have distribution shift issues that…

Machine Learning · Computer Science 2021-03-12 Ye Ye , Andrew Gu