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The sensitivity analysis of biological system models can significantly contribute to identifying and explaining influences of internal or external changes on model and its elements. We propose here a comprehensive framework to study…

Molecular Networks · Quantitative Biology 2019-02-11 Gaoxiang Zhou , Kai-Wen Liang , Natasa Miskov-Zivanov

Many multivariate functions in engineering models vary primarily along a few directions in the space of input parameters. When these directions correspond to coordinate directions, one may apply global sensitivity measures to determine the…

Numerical Analysis · Mathematics 2014-07-28 Paul G. Constantine , Eric Dow , Qiqi Wang

We propose Partially Interpretable Estimators (PIE) which attribute a prediction to individual features via an interpretable model, while a (possibly) small part of the PIE prediction is attributed to the interaction of features via a…

Machine Learning · Computer Science 2021-05-07 Tong Wang , Jingyi Yang , Yunyi Li , Boxiang Wang

In this study, we investigate and compare formulations for computing shape derivatives in bi-material level-set optimization with precise modeling of the interface. The level-set function is parameterized using B-splines, whose coordinates…

Classical Physics · Physics 2024-10-30 Majd Kosta , Oded Amir

In observational studies, exposures are often continuous rather than binary or discrete. At the same time, sensitivity analysis is an important tool that can help determine the robustness of a causal conclusion to a certain level of…

Methodology · Statistics 2025-12-15 Jeffrey Zhang

The path-length dependence of jet quenching can help to constrain different jet quenching mechanisms in heavy-ion collisions. However, measuring an explicit value for this dependence has proven challenging. Traditional approaches, which…

Nuclear Experiment · Physics 2023-08-23 Caitlin Beattie

Panel data models with unobserved heterogeneity in the form of interactive effects standardly assume that the time effects -- or ``common factors'' -- enter linearly. This assumption is restrictive because it concerns an unobserved…

Econometrics · Economics 2026-05-29 Christina Maschmann , Joakim Westerlund

Estimating individual treatment effects (ITE) from observational data is a critical task across various domains. However, many existing works on ITE estimation overlook the influence of hidden confounders, which remain unobserved at the…

Machine Learning · Computer Science 2024-12-06 Binbin Hu , Zhicheng An , Zhengwei Wu , Ke Tu , Ziqi Liu , Zhiqiang Zhang , Jun Zhou , Yufei Feng , Jiawei Chen

We propose an efficient sensitivity analysis method for a wide class of colored noise-driven interacting particle systems (IPS). Our method is based on unperturbed simulations and significantly extends the Malliavin weight sampling method…

Probability · Mathematics 2024-06-18 Josselin Garnier , Harry L. F. Ip , Laurent Mertz

Empathy plays a critical role in software engineering (SE), influencing collaboration, communication, and user-centred design. Although SE research has increasingly recognised empathy as a key human aspect, there remains no validated…

Software Engineering · Computer Science 2025-10-15 Hashini Gunatilake , John Grundy , Rashina Hoda , Ingo Mueller

The interpretation of feature importance in machine learning models is challenging when features are dependent. Permutation feature importance (PFI) ignores such dependencies, which can cause misleading interpretations due to extrapolation.…

Machine Learning · Statistics 2023-11-09 Christoph Molnar , Gunnar König , Bernd Bischl , Giuseppe Casalicchio

Sensitivity analyses of simulation ensembles determine how simulation parameters influence the simulation's outcome. Commonly, one global numerical sensitivity value is computed per simulation parameter. However, when considering 3D spatial…

Human-Computer Interaction · Computer Science 2024-08-08 Marina Evers , Simon Leistikow , Hennes Rave , Lars Linsen

Global Sensitivity Analysis (GSA) is the study of the influence of any given inputs on the outputs of a model. In the context of engineering design, GSA has been widely used to understand both individual and collective contributions of…

Machine Learning · Statistics 2024-03-06 Yigitcan Comlek , Liwei Wang , Wei Chen

Impedance models of power systems are useful when state-space models of apparatus such as inverter-based resources (IBRs) have not been made available and instead only black-box impedance models are available. For tracing the root causes of…

Systems and Control · Electrical Eng. & Systems 2022-04-05 Yue Zhu , Yunjie Gu , Yitong Li , Timothy C. Green

Multivariate imputation by chained equations (MICE) is one of the most popular approaches to address missing values in a data set. This approach requires specifying a univariate imputation model for every variable under imputation. The…

Methodology · Statistics 2023-11-01 Edoardo Costantini , Kyle M. Lang , Klaas Sijtsma

In the context of air quality control, our objective is to quantify the impact of uncertain inputs such as meteorological conditions and traffic parameters on pollutant dispersion maps. It is worth noting that the majority of sensitivity…

The Sobol' indices are a recognized tool in global sensitivity analysis. When the uncertain variables in a model are statistically independent, the Sobol' indices may be easily interpreted and utilized. However, their interpretation and…

Data Analysis, Statistics and Probability · Physics 2018-08-17 Joseph Hart , Pierre Gremaud

Inverse design has made vast physical parameter spaces a substrate for emergent behavior. In sensing, the stakes of this principle are sharpest at the analog-to-digital boundary, where any information the hardware fails to capture is…

Optics · Physics 2026-04-29 Arvin Keshvari , William Tuxbury , Zin Lin

Sensitivity analysis plays an important role in the development of computer models/simulators through identifying the contribution of each (uncertain) input factor to the model output variability. This report investigates different aspects…

Computation · Statistics 2022-06-24 Hossein Mohammadi , Peter Challenor , Clémentine Prieur

We present an HSIC-based approach for global sensitivity analysis of broad classes of models with correlated and possibly function-valued inputs and outputs. To this end, we define the total HSIC sensitivity index: a bounded, interpretable,…

Statistics Theory · Mathematics 2026-03-03 Troy Larsen , Alen Alexanderian