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Ensuring diagnostic performance of AI models before clinical use is key to the safe and successful adoption of these technologies. Studies reporting AI applied to digital pathology images for diagnostic purposes have rapidly increased in…

Whole slide image (WSI) registration is an essential task for analysing the tumour microenvironment (TME) in histopathology. It involves the alignment of spatial information between WSIs of the same section or serial sections of a tissue…

Image and Video Processing · Electrical Eng. & Systems 2025-02-27 Behnaz Elhaminia , Abdullah Alsalemi , Esha Nasir , Mostafa Jahanifar , Ruqayya Awan , Lawrence S. Young , Nasir M. Rajpoot , Fayyaz Minhas , Shan E Ahmed Raza

Despite their powerful chat, coding, and reasoning abilities, Large Language Models (LLMs) frequently hallucinate. Conventional wisdom suggests that hallucinations are a consequence of a balance between creativity and factuality, which can…

Face hallucination, which is the task of generating a high-resolution face image from a low-resolution input image, is a well-studied problem that is useful in widespread application areas. Face hallucination is particularly challenging…

Computer Vision and Pattern Recognition · Computer Science 2016-04-28 Oncel Tuzel , Yuichi Taguchi , John R. Hershey

In this paper we address the problem of hallucinating high-resolution facial images from unaligned low-resolution inputs at high magnification factors. We approach the problem with convolutional neural networks (CNNs) and propose a novel…

Computer Vision and Pattern Recognition · Computer Science 2019-02-12 Klemen Grm , Simon Dobrišek , Walter J. Scheirer , Vitomir Štruc

Histopathology whole slide images (WSIs) play a very important role in clinical studies and serve as the gold standard for many cancer diagnoses. However, generating automatic tools for processing WSIs is challenging due to their enormous…

Computer Vision and Pattern Recognition · Computer Science 2022-09-28 Jingwei Zhang , Xin Zhang , Ke Ma , Rajarsi Gupta , Joel Saltz , Maria Vakalopoulou , Dimitris Samaras

Hallucination in large language models (LLMs) has been widely studied in recent years, with progress in both detection and mitigation aimed at improving truthfulness. Yet, a critical side effect remains largely overlooked: enhancing…

Computation and Language · Computer Science 2026-02-02 Omar Mahmoud , Ali Khalil , Buddhika Laknath Semage , Thommen George Karimpanal , Santu Rana

Hallucinations in large language models (LLMs) during summarization of patient-clinician dialogues pose significant risks to patient care and clinical decision-making. However, the phenomenon remains understudied in the clinical domain,…

Large Language Models (LLMs) exhibit impressive linguistic competence but also produce inaccurate or fabricated outputs, often called ``hallucinations''. Engineering approaches usually regard hallucination as a defect to be minimized, while…

Computation and Language · Computer Science 2025-10-08 Bowen Xu

Large Language Models (LLMs) have succeeded in a variety of natural language processing tasks [Zha+25]. However, they have notable limitations. LLMs tend to generate hallucinations, a seemingly plausible yet factually unsupported output…

Computation and Language · Computer Science 2025-09-19 Martin Preiß

Histopathology whole slide images (WSIs) can reveal significant inter-hospital variability such as illumination, color or optical artifacts. These variations, caused by the use of different scanning protocols across medical centers…

Computer Vision and Pattern Recognition · Computer Science 2022-07-01 Marin Scalbert , Maria Vakalopoulou , Florent Couzinié-Devy

Whole-slide images (WSI) in computational pathology have high resolution with gigapixel size, but are generally with sparse regions of interest, which leads to weak diagnostic relevance and data inefficiency for each area in the slide. Most…

Computer Vision and Pattern Recognition · Computer Science 2022-12-14 Boxuan Zhao , Jun Zhang , Deheng Ye , Jian Cao , Xiao Han , Qiang Fu , Wei Yang

The class distribution of data is one of the factors that regulates the performance of machine learning models. However, investigations on the impact of different distributions available in the literature are very few, sometimes absent for…

Computer Vision and Pattern Recognition · Computer Science 2020-12-23 Ismat Ara Reshma , Sylvain Cussat-Blanc , Radu Tudor Ionescu , Hervé Luga , Josiane Mothe

Concerns regarding the propensity of Large Language Models (LLMs) to produce inaccurate outputs, also known as hallucinations, have escalated. Detecting them is vital for ensuring the reliability of applications relying on LLM-generated…

Computation and Language · Computer Science 2024-05-31 Ernesto Quevedo , Jorge Yero , Rachel Koerner , Pablo Rivas , Tomas Cerny

Diffusion probabilistic models (DPMs) have demonstrated remarkable progress in generative tasks, such as image and video synthesis. However, they still often produce hallucinated samples (hallucinations) that conflict with real-world…

Computer Vision and Pattern Recognition · Computer Science 2025-12-16 Shuai Fu , Jian Zhou , Qi Chen , Huang Jing , Huy Anh Nguyen , Xiaohan Liu , Zhixiong Zeng , Lin Ma , Quanshi Zhang , Qi Wu

Over the past few decades, numerous attempts have been made to address the problem of recovering a high-resolution (HR) facial image from its corresponding low-resolution (LR) counterpart, a task commonly referred to as face hallucination.…

Computer Vision and Pattern Recognition · Computer Science 2021-11-23 Ali Abbasi , Mohammad Rahmati

Large language models (LLMs) frequently generate confident yet inaccurate responses, introducing significant risks for deployment in safety-critical domains. We present a novel, test-time approach to detecting model hallucination through…

Machine Learning · Computer Science 2025-10-07 Hazel Kim , Tom A. Lamb , Adel Bibi , Philip Torr , Yarin Gal

Whole slide images (WSIs) are gigapixel-scale digital images of H\&E-stained tissue samples widely used in pathology. The substantial size and complexity of WSIs pose unique analytical challenges. Multiple Instance Learning (MIL) has…

Computer Vision and Pattern Recognition · Computer Science 2024-08-20 Jun Wang , Yu Mao , Nan Guan , Chun Jason Xue

With the development of computer-aided diagnosis (CAD) and image scanning technology, Whole-slide Image (WSI) scanners are widely used in the field of pathological diagnosis. Therefore, WSI analysis has become the key to modern digital…

Computer Vision and Pattern Recognition · Computer Science 2021-02-23 Chen Li , Xintong Li , Md Rahaman , Xiaoyan Li , Hongzan Sun , Hong Zhang , Yong Zhang , Xiaoqi Li , Jian Wu , Yudong Yao , Marcin Grzegorzek

Whole-slide image (WSI) classification is a challenging task because 1) patches from WSI lack annotation, and 2) WSI possesses unnecessary variability, e.g., stain protocol. Recently, Multiple-Instance Learning (MIL) has made significant…

Computer Vision and Pattern Recognition · Computer Science 2025-08-12 Joohyung Lee , Heejeong Nam , Kwanhyung Lee , Sangchul Hahn