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Spatial Transcriptomics (ST) provides spatially resolved gene expression profiles within intact tissue architecture, enabling molecular analysis in histological context. However, the high cost, limited throughput, and restricted data…

Generative Adversarial Networks (GANs) have recently advanced image synthesis by learning the underlying distribution of the observed data. However, how the features learned from solving the task of image generation are applicable to other…

This paper introduces a novel deep-learning approach to predict true stress-strain curves of high-strength steels from small punch test (SPT) load-displacement data. The proposed approach uses Gramian Angular Field (GAF) to transform…

The intrinsic stochasticity of gene expression can lead to large variability of protein levels across a population of cells. Variability (or noise) in protein distributions can be modulated by cellular mechanisms of gene regulation; in…

Coherent imaging systems like synthetic aperture radar are susceptible to multiplicative noise that makes applications like automatic target recognition challenging. In this paper, NeighCNN, a deep learning-based speckle reduction algorithm…

Training loss and accuracy are the standard signals used to monitor generalization during deep neural network training. Two well-documented phenomena complicate this picture: in grokking, train loss falls rapidly while test performance…

Ultra high-throughput sequencing of transcriptomes (RNA-Seq) is a widely used method for quantifying gene expression levels due to its low cost, high accuracy and wide dynamic range for detection. However, the nature of RNA-Seq makes it…

In many transcriptomic studies, the correlation of genes might fluctuate with quantitative factors such as genetic ancestry. We propose a method that models the covariance between two variables to vary against a continuous covariate. For…

Medical experts often manually segment images to obtain diagnostic statistics and discard the resulting annotations. We aim to train segmentation models to alleviate this burden, but constrained to the retained summary statistics (e.g., the…

The field of medical image segmentation is challenged by domain generalization (DG) due to domain shifts in clinical datasets. The DG challenge is exacerbated by the scarcity of medical data and privacy concerns. Traditional single-source…

We study several Fokker-Planck equations arising from a stochastic chemical kinetic system modeling a gene regulatory network in biology. The densities solving the Fokker-Planck equations describe the joint distribution of the messenger RNA…

The sample selection approach is very popular in learning with noisy labels. As deep networks learn pattern first, prior methods built on sample selection share a similar training procedure: the small-loss examples can be regarded as clean…

We propose a new test statistic based on a score process for determining the statistical significance of a putative signal that may be a small perturbation to a noisy experimental background. We derive the reference distribution for this…

This paper proposes a Residual Convolutional Neural Network (ResNet) based on speech features and trained under Focal Loss to recognize emotion in speech. Speech features such as Spectrogram and Mel-frequency Cepstral Coefficients (MFCCs)…

Symbolic regression, the task of predicting the mathematical expression of a function from the observation of its values, is a difficult task which usually involves a two-step procedure: predicting the "skeleton" of the expression up to the…

The prediction of disease risk factors can screen vulnerable groups for effective prevention and treatment, so as to reduce their morbidity and mortality. Machine learning has a great demand for high-quality labeling information, and…

Nowadays stochastic approximation methods are one of the major research direction to deal with the large-scale machine learning problems. From stochastic first order methods, now the focus is shifting to stochastic second order methods due…

Level set estimation (LSE), the problem of identifying the set of input points where a function takes value above (or below) a given threshold, is important in practical applications. When the function is expensive-to-evaluate and…

Anatomical landmark segmentation and pathology localization are important steps in automated analysis of medical images. They are particularly challenging when the anatomy or pathology is small, as in retinal images and cardiac MRI, or when…

Sparse linear regression is one of the classic problems in the field of statistics, which has deep connections and high intersections with optimization, computation, and machine learning. To address the effective handling of…